EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

monobenzone
hydroquinone monobenzyl ether

Supplier Sponsors

Name:4-phenylmethoxyphenol
CAS Number: 103-16-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-083-3
FDA UNII: 9L2KA76MG5
Nikkaji Web:J5.012A
Beilstein Number:1958305
MDL:MFCD00002333
XlogP3:3.40 (est)
Molecular Weight:200.23704000
Formula:C13 H12 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):103-16-2 ; HYDROQUINONE MONOBENZYL ETHER
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 122.50 °C. @ 760.00 mm Hg
Boiling Point: 359.00 to 360.00 °C. @ 760.00 mm Hg (est)
Flash Point: 416.00 °F. TCC ( 213.40 °C. ) (est)
logP (o/w): 2.651 (est)
Soluble in:
 water, 251.4 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Monobenzone >98%
Odor: characteristic
Use: Monobenzone is a compound used as a topical agent for medical depigmentation.T
Glentham Life Sciences
4-(Benzyloxy)phenol
Jiangyin Healthway
Monobenzone
New functional food ingredients
Jiangyin Healthway
monobenzone(4-Benzyloxyphenol)
Santa Cruz Biotechnology
For experimental / research use only.
4-(Benzyloxy)phenol ≥99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-(Benzyloxy)phenol 98%
sds
TCI AMERICA
For experimental / research use only.
4-(Benzyloxy)phenol >99.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-rat LD50 4500 mg/kg
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 983, 1989.

intraperitoneal-mouse LD50 > 600 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for monobenzone usage levels up to:
 not for fragrance use.
 
Recommendation for monobenzone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):103-16-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7638
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
4-phenylmethoxyphenol
Chemidplus:0000103162
RTECS:SJ7700000 for cas# 103-16-2
 
References:
 4-phenylmethoxyphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:103-16-2
Pubchem (cid):7638
Pubchem (sid):134971909
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14244
HMDB (The Human Metabolome Database):HMDB14738
Export Tariff Code:2909.50.5000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
it is marketed as monobenzone lotion, nf, 5% soln in isopropyl alcohol & propylene glycol, & monobenzone ointment, nf, which contains 20% of active ingredient in suitable base.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 agerite alba
p-benzoxyphenol
para-benzoxyphenol
4-(benzyl oxy) phenol
 benzyl p-hydroxyphenyl ether
 benzyl para-hydroxyphenyl ether
4-(benzyl-oxy)phenol
4-benzyloxy phenol
4-benzyloxy-phenol
p-(benzyloxy) phenol
4-(benzyloxy)benzolol
4-(benzyloxy)phenol
p-(benzyloxy)phenol
4-(benzyloxyl)phenol
4-benzyloxyphenol
p-benzyloxyphenol
 hydroquinone monobenzyl ether
p-hydroxyphenyl benzyl ether
 phenol, 4-(phenylmethoxy)-
 phenol, 4-benzyloxy-
 phenol, p-(benzyloxy)-
4-(phenylmethoxy)phenol
4-phenylmethoxyphenol
 

Articles:

PubMed:Different effects of five depigmentary compounds, rhododendrol, raspberry ketone, monobenzone, rucinol and AP736 on melanogenesis and viability of human epidermal melanocytes.
PubMed:A mouse model of vitiligo induced by monobenzone.
PubMed:Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity.
PubMed:Successful treatment of extensive vitiligo with monobenzone.
PubMed:Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy.
PubMed:The therapeutic effects of EGCG on vitiligo.
PubMed:Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG.
PubMed:Pre-clinical evidences of Pyrostegia venusta in the treatment of vitiligo.
PubMed:A reactive ortho-quinone generated by tyrosinase-catalyzed oxidation of the skin depigmenting agent monobenzone: self-coupling and thiol-conjugation reactions and possible implications for melanocyte toxicity.
PubMed:Corneal and conjunctival effects of monobenzone in patients with vitiligo.
PubMed:Monobenzone, Superfade, vitiligo and confetti-like depigmentation.
PubMed:Dermatitis produced by applications of monobenzone in patients with active vitiligo.
PubMed:Diffuse leukoderma following use of monobenzone.
PubMed:MONOBENZONE.
PubMed:Evaluation of monobenzone.
PubMed:Enhanced bleaching treatment: opportunities for immune-assisted melanocyte suicide in vitiligo.
PubMed:Breaking immunological tolerance to melanocyte differentiation antigens by hypopigmenting agents: a new means for melanoma immunotherapy?
PubMed:Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.
PubMed:Accelerating bleaching in vitiligo: balancing benefits versus risks.
PubMed:Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress.
PubMed:Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.
PubMed:Depigmentation therapies for normal skin in vitiligo universalis.
PubMed:The development of guidelines for the treatment of vitiligo. Clinical Epidemiology Unit of the Istituto Dermopatico dell'Immacolata-Istituto di Recovero e Cura a Carattere Scientifico (IDI-IRCCS) and the Archives of Dermatology.
PubMed:How we treat vitiligo.
PubMed:Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation.
PubMed:New and experimental treatments of vitiligo and other hypomelanoses.
PubMed:Retinoic acid synergistically enhances the melanocytotoxic and depigmenting effects of monobenzylether of hydroquinone in black guinea pig skin.
PubMed:Footwear depigmentation.
PubMed:Rapid repigmentation after depigmentation therapy: vitiligo treated with monobenzyl ether of hydroquinone.
PubMed:Achromic patch test from hydroquinone monobenzyl ether.
PubMed:The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.
PubMed:Contact depigmentation of the breast.
PubMed:Should vitiligo be treated?
PubMed:[Leukomelanodermia areata (dyschromia "en confetti") caused by the application of monobenzylether of hydroquinone (author's transl)].
PubMed:[Irreversible toxic depigmentation. Observations following use of hydroquinonemonobenzylether-containing skin bleaching preparations].
PubMed:Contact hypersensitivity to monobenzyl ether of hydroquinone used to treat vitiligo.
PubMed:Dyschromatosis.
PubMed:A case report of extensive vitiligo.
PubMed:Treatment of nonhairy melanocytic macules by dermabrasion and topical application of 5% hydroquinone monobenzyl ether cream.
PubMed:Hearing aid depigmentation.
PubMed:Influence of depigmenting chemical agents on hair and skin color in yellow (pheomelanic) and black (eumelanic) mice.
PubMed:[Confetti-like dyschromia caused by a bleaching cream containing hydroquinone in racially pigmented patients].
PubMed:Modulation of the population density of identifiable epidermal Langerhans cells associated with enhancement or suppression of cutaneous immune reactivity.
PubMed:[Treatment of vitiligo].
PubMed:[Therapy of melanin-induced pigment anomalies].
PubMed:Sensitization to hydroquinone and the monobenzyl ether of hydroquinone.
PubMed:[Acquired leukomelanoderma caused by topical depigmenting agents].
PubMed:Screening of depigmenting compounds for the development of an alternate method of branding beef cattle.
PubMed:[Eye diseases attributable to dermatologic therapy].
PubMed:Vitiligo: a manifestation of apoptosis?
PubMed:Vitiligo.
PubMed:Cutaneous reactions to topical application of hydroquinone. Results of a 6-year investigation.
 
Notes:
None found
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