EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

3-methyl-laevo-histidine
L-histidine, 3-methyl-

Supplier Sponsors

Name:(2S)-2-amino-3-(3-methylimidazol-4-yl)propanoic acid
CAS Number: 368-16-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-704-6
FDA UNII: MEH8O8Y0H0
Nikkaji Web:J111.364J
MDL:MFCD00083658
XlogP3-AA:-3.30 (est)
Molecular Weight:169.18407000
Formula:C7 H11 N3 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 2.00E+05 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
3-Methyl-L-histidine 95%
Sigma-Aldrich: Sigma
For experimental / research use only.
3-Methyl-L-histidine
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 3-methyl-laevo-histidine usage levels up to:
 not for fragrance use.
 
Recommendation for 3-methyl-laevo-histidine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :64969
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S)-2-amino-3-(3-methylimidazol-4-yl)propanoic acid
Chemidplus:0000368161
 
References:
 (2S)-2-amino-3-(3-methylimidazol-4-yl)propanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):64969
Pubchem (cas):368-16-1
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
KEGG (GenomeNet):C01152
HMDB (The Human Metabolome Database):HMDB00479
FooDB:FDB021798
YMDB (Yeast Metabolome Database):YMDB00703
Export Tariff Code:2933.29.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
(2S)-2-amino-3-(3-methylimidazol-4-yl)propanoic acid
L-histidine, 3-methyl-
3-methyl-L-histidine
3-methylhistidine
 

Articles:

PubMed:Effects of a honeybee sting on the serum free amino acid profile in humans.
PubMed:Carnosinases, their substrates and diseases.
PubMed:Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross-sectional study and review of literature.
PubMed:Protein properties of mackerel viscera extracted by supercritical carbon dioxide.
PubMed:O2 binding to human serum albumin incorporating iron porphyrin with a covalently linked methyl-L-histidine isomer.
PubMed:New glycosidic derivatives of histidine-containing dipeptides with antioxidant properties and resistant to carnosinase activity.
PubMed:Evaluating the roles of the heme a side chains in cytochrome c oxidase using designed heme proteins.
PubMed:Concentrations of carnosine, anserine, L-histidine and 3-methyl histidine in boar spermatozoa and sheep milk by a modified HPLC method.
PubMed:Evaluation of electron-withdrawing group effects on heme binding in designed proteins: implications for heme a in cytochrome c oxidase.
PubMed:Glutaraldehyde (GA)-hapten adducts, but without a carrier protein, for use in a specificity study on an antibody against a GA-conjugated hapten compound: histamine monoclonal antibody (AHA-2) as a model.
PubMed:Cobalt-mediated generation of reactive oxygen species and its possible mechanism.
PubMed:Generation of reactive oxygen species by Co(II) from H2O2 in the presence of chelators in relation to DNA damage and 2'-deoxyguanosine hydroxylation.
PubMed:Enhanced generation of hydroxyl radical and sulfur trioxide anion radical from oxidation of sodium sulfite, nickel(II) sulfite, and nickel subsulfide in the presence of nickel(II) complexes.
PubMed:Mutagenicity testing of protein-containing and biological samples using the Ames/Salmonella plate incorporation test and the fluctuation test.
PubMed:Generation of free radicals from lipid hydroperoxides by Ni2+ in the presence of oligopeptides.
PubMed:Tumor necrosis factor induces skeletal muscle protein breakdown in rats.
PubMed:IGF-I and the truncated analogue des-(1-3)IGF-I enhance growth in rats after gut resection.
PubMed:Effect of systemic hyperinsulinemia on amino acid flux across human legs in postabsorptive state.
PubMed:Effect of surgical injury and intraoperative hypothermia on whole body protein metabolism.
PubMed:Insulin- and thyroid hormone-independent adaptation of myofibrillar proteolysis to glucocorticoids.
PubMed:Insulin responsiveness of protein metabolism in vivo following bedrest in humans.
PubMed:Strength conditioning in older men: skeletal muscle hypertrophy and improved function.
PubMed:Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis.
PubMed:Practical observations on the methodology for determining 3-methyl-l-histidine using fluorescamine derivatives.
PubMed:Variations in the levels of 3-methyl-l-histidine of the myosins within the bovine carcass.
PubMed:Determination of 3 methyl-L-histidine in human urine by ion exchange high performance liquid chromatography. Applications to patients in post-operative surgical care.
PubMed:Oxidation, photosensitized by certain diketones, of enzymes and protection against such oxidation by histidine derivatives.
 
Notes:
3-Methylhistidine is a product of peptide bond synthesis and methylation of actin and myosin. The measurement of 3-Methylhistidine provides an index of the rate of muscle protein breakdown. [HMDB]
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