EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

amitrole
3-amino-1H-1,2,4-triazole

Supplier Sponsors

CAS Number: 61-82-5Picture of molecule3D/inchi
Other(deleted CASRN):1057722-43-6
ECHA EINECS - REACH Pre-Reg:200-521-5
FDA UNII: ZF80H5GXUF
Nikkaji Web:J2.345K
Beilstein Number:107687
MDL:MFCD00005230
XlogP3-AA:-0.40 (est)
Molecular Weight:84.08188000
Formula:C2 H4 N4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 159.00 °C. @ 760.00 mm Hg
Boiling Point: 347.20 °C. @ 760.00 mm Hg (est)
Vapor Pressure:4.400000 mmHg @ 25.00 °C. (est)
Flash Point: 375.00 °F. TCC ( 190.70 °C. ) (est)
logP (o/w): -0.860
Soluble in:
 water, 2.80E+05 mg/L @ 25 °C (exp)
 water, 8.649e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
3-Amino-1,2,4-triazole
Charkit Chemical
AMINO-1,2,4-TRIAZOLE, 3-
Glentham Life Sciences
3-Amino-1,2,4-triazole
Santa Cruz Biotechnology
For experimental / research use only.
3-Amino-1,2,4-triazole ≥95%
Sigma-Aldrich
For experimental / research use only.
Amitrole PESTANAL®, analytical standard
TCI AMERICA
For experimental / research use only.
3-Amino-1,2,4-triazole >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 200 mg/kg
National Technical Information Service. Vol. AD277-689

intravenous-mouse LD50 > 5000 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 13, Pg. 597, 1977.

oral-mouse LD50 14700 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 33, 1966.

oral-quail LD50 > 316 mg/kg
Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982.

oral-rat LD50 1100 mg/kg
Residue Reviews. Vol. 10, Pg. 97, 1965.

Dermal Toxicity:
skin-rat LD50 > 10000 mg/kg
World Review of Pest Control. Vol. 9, Pg. 119, 1970.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
herbicides / pesticides
Recommendation for amitrole usage levels up to:
 not for fragrance use.
 
Recommendation for amitrole flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Conclusion on the peer review of the pesticide risk assessment of the active substance amitrole
View page or View pdf

Protocol for the evaluation of data concerning the necessity of the application of herbicide active substances to control a serious danger to plant health which cannot be contained by other available means, including non-chemical methods
View page or View pdf

EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):61-82-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1639
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
1H-1,2,4-triazol-5-amine
Chemidplus:0000061825
EPA/NOAA CAMEO:hazardous materials
RTECS:61-82-5
 
References:
 1H-1,2,4-triazol-5-amine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:61-82-5
Pubchem (cid):1639
Pubchem (sid):134971359
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C11261
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.99.8500
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•amizine is trade name for mixture of amitrole & simazine and fenamine refers to combination of amitrole, fenac & atrazine. •kleer-lot (mixture of amitrole & linuron) . •amino triazole weedkiller 90 is dry soluble powder formulation containing 90% active ingredient. cytrol amitrole-t liquid weedkiller is water soluble formulation containing 2 lbs amino triazole plus 19% ammonium thiocyanategal. •pure, technical grades •amizine is a mixture of amitrole & princep; diurol 5030 is amitrole with diuron; fenamine is amitrole with fenac & atrazine; fenavar liq is amitrole with bromacil & ammonium thiocyanate; simazol is a mixture of simazine & amitrole; ustilan nk, ustilan t, ustinex are amitrole in combination with different herbicides. farmco amizine-aa contains 320 gl amitrole, 320 gl atrazine; farmco amitrol-t is 250 gl amitrole, 220 gl ammonium thiocyanate. mixtures •soluble powder, soluble concentrate, suspension concentrate, water soluble, wettable powder, or flakes. •discontinued trade names: amino triazole weed killer-90; amizine; at-90; at-liquid; cytrol amitrole-t; diurol; farmaco; herbixol; herbizole; kleer-lot; phoscatrol; uracom; ustilan gw; weedazol t •the only available formulation for amitrole is a 90% wettable powder. the registrant voluntarily cancelled the 21.6% emulsifiable concentrate formulation in 1996. •trade name: amitrole
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
3-amino-1,2,4-triazole
2-amino-1,3,4-triazole
3-amino-1H-1,2,4-triazole
2-aminotriazole
 amitrol
 amizol D
 cytrole
 diurol 5030
 emisol 50
 fenavar
 herbidal total
 herbizole
 kleer-lot
 orga-414
 radoxone TL
 ramizol
 simazol
1H-1,2,4-triazol-3-ylamine
1H-1,2,4-triazol-5-amine
 vorox AA
 weedar ADS
 weedazin
 weedazol
 weedazol T
 weedoclor
 x-all liquid
 

Articles:

PubMed:Rapid detection of pesticides not amenable to multi-residue methods by flow injection-tandem mass spectrometry.
PubMed:Aminotriazole attenuated carbon tetrachloride-induced oxidative liver injury in mice.
PubMed:β-ODAP accumulation could be related to low levels of superoxide anion and hydrogen peroxide in Lathyrus sativus L.
PubMed:Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells.
PubMed:Determination of amitrole in environmental water samples with precolumn derivatization by high-performance liquid chromatography.
PubMed:Oxidative alterations induced by D-aspartic acid in prepubertal rat testis in vitro: a mechanistic study.
PubMed:[Effects of amitrole on thyroid hormone-associated gene transcription in FRTL-5 cells].
PubMed:Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents.
PubMed:Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus.
PubMed:Acetylation of 5-amino-1H-[1,2,4]triazole revisited.
PubMed:Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status.
PubMed:Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
PubMed:Pentachlorophenol-induced oxidative DNA damage in mouse liver and protective effect of antioxidants.
PubMed:Effects of aminotriazole on ethanol, water, and food intake and on brain catalase in UChA and UChB rats.
PubMed:A role for thyroid hormones in cold-induced elevation of blood pressure and cardiac hypertrophy.
PubMed:Production of β-damascenone precursors in cell cultures of Vitis labruscana cv Concord grapes.
PubMed:Effects of 3-amino-1,2,4-triazole on brain catalase in the mediation of ethanol consumption in mice.
PubMed:Origin of reactive oxygen species in erythrocytes infected with Plasmodium falciparum.
PubMed:Response of the medullary thick ascending limb to hypothyroidism in the rat.
PubMed:Kidney structure in hypothyroidism.
PubMed:Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats.
PubMed:Potential carcinogenicity of food additives and contaminants.
PubMed:Absorption of herbicides by wheat as influenced by the phenoxy compound.
PubMed:Insecticide inhibition of herbicide metabolism in leaf tissues.
PubMed:Extraction of 3-amino-1,2,4-triazole (amitrole) and 2,6-dichloro-4-nitroaniline (DCNA) from soils.
 
Notes:
a non-selective post-emergence, translocated herbicide. according to the seventh annual report on carcinogens (pb95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (from merck index, 12th ed) it is an irreversible inhibitor of catalase, and thus impairs activity of peroxisomes.
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