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Category:solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.05300 to 1.05600 @ 20.00 °C.
|
| Pounds per Gallon - (est).: | 8.772 to 8.797
|
| Refractive Index: | 1.43800 to 1.44100 @ 20.00 °C.
|
| Boiling Point: | 214.00 to 215.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.034000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 175.00 °F. TCC ( 79.44 °C. )
|
| logP (o/w): | -1.040 (est) |
| Soluble in: |
| | alcohol | | | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 1,3-Dihydroxypropane
|
| Connect Chemicals |
| Bio-1,3-Propanediol
Odor: characteristic Use: bio-Propanediol can act as multipurpose ingredient: emollient, humectant, booster, solvent, viscosity enhancer and carrier for actives.
bio-Propanediol is a high purity ingredient 100% from renewable sources GMO-free. |
| ECSA Chemicals |
| PROPANEDIOL NATURAL
|
| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| EMD Millipore |
| For experimental / research use only. |
| 1,3-Propanediol
|
| Penta International |
| 1,3-PROPANEDIOL NATURAL
|
| Penta International |
| 1,3-PROPANEDIOL NF
|
| Penta International |
| 1,3-PROPANEDIOL
|
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 1,3-Propanediol ≥99%
|
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 1,3-Propanediol 98%
|
| TCI AMERICA |
| For experimental / research use only. |
| 1,3-Propanediol >98.0%(GC)
|
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 4780 mg/kg
Toxicology and Applied Pharmacology. Vol. 49, Pg. 385, 1979.
oral-cat LDLo 3000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 72, Pg. 227, 1941.
unreported-mouse LD50 10930 mg/kg
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986
intravenous-rabbit LDLo 3000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 72, Pg. 227, 1941.
intramuscular-rat LDLo 6000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 72, Pg. 227, 1941.
oral-rat LDLo 10000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 72, Pg. 227, 1941.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | solvents |
| Recommendation for 1,3-propane diol usage levels up to: | | | not for fragrance use.
|
| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 26 |
| Click here to view publication 26 |
| | average usual ppm | average maximum ppm |
| baked goods: | 1300.00000 | 1300.00000 |
| beverages(nonalcoholic): | 690.00000 | 690.00000 |
| beverages(alcoholic): | 690.00000 | 690.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | 1800.00000 | 1800.00000 |
| condiments / relishes: | 20.00000 | 20.00000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | 810.00000 | 810.00000 |
| fruit ices: | 810.00000 | 810.00000 |
| gelatins / puddings: | 250.00000 | 290.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | 1300.00000 | 1300.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | 300.00000 | 300.00000 |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | 1300.00000 | 1300.00000 |
| soups: | 20.00000 | 20.00000 |
| sugar substitutes: | - | - |
| sweet sauces: | 7000.00000 | 7000.00000 |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | deoxyglycerol | | 1,3- | dihydroxypropane | | 2-( | hydroxymethyl)ethanol | | | propan-1,3-diol | | 1,3- | propandiol | | 1,3- | propane diol | | | propane-1,3-diol | | 1,3- | propanediol | | 1,3- | propylene glycol | | beta- | propylene glycol | | 1,3- | propylenediol | | | trimethylene glycol |
Articles:
| PubMed:Effect of 1,3-propanediol, organic acids, and ethanol on growth and metabolism of Clostridium butyricum DSP1. |
| PubMed:Biotechnological potential of Clostridium butyricum bacteria. |
| PubMed:Hypothetical glycerol pathways of newly isolated strains capable of 1,3-propanediol production. |
| PubMed:Fully glycerol-independent microbial production of 1, 3-propanediol via non-natural pathway: Paving the way to success with synthetic tiles. |
| PubMed:2-Chloro-1,3-propanediol (2-MCPD) and its fatty acid esters: cytotoxicity, metabolism, and transport by human intestinal Caco-2 cells. |
| PubMed:Metabolic Engineering of a Glycerol-Oxidative Pathway in Lactobacillus panis PM1 for Utilization of Bioethanol Thin Stillage: Potential To Produce Platform Chemicals from Glycerol. |
| PubMed:Impurities of crude glycerol and their effect on metabolite production. |
| PubMed:Identification of a new angiotensin-converting enzyme (ACE) inhibitor from Thai edible plants. |
| PubMed:Conversion of glycerol to 1,3-propanediol by Citrobacter freundii and Hafnia alvei - newly isolated strains from the Enterobacteriaceae. |
| PubMed:Biorefinery development through utilization of biodiesel industry by-products as sole fermentation feedstock for 1,3-propanediol production. |
| PubMed:Transcriptional repressor role of PocR on the 1,3-propanediol biosynthetic pathway by Lactobacillus panis PM1. |
| PubMed:Scale-up of anaerobic 1,3-propanediol production by Clostridium butyricum DSP1 from crude glycerol. |
| PubMed:Biosynthesis of 1,3-propanediol from glycerol with Lactobacillus reuteri: effect of operating variables. |
| PubMed:Bioconversion of glycerol to 1,3-propanediol in thin stillage-based media by engineered Lactobacillus panis PM1. |
| PubMed:Enhanced production of 3-hydroxypropionic acid from glycerol by modulation of glycerol metabolism in recombinant Escherichia coli. |
| PubMed:[Construction of polyhydroxybutyrate pathway in Klebsiella pneumoniae]. |
| PubMed:Microbial purification of postfermentation medium after 1,3-PD production from raw glycerol. |
| PubMed:Denitrification of industrial wastewater: Influence of glycerol addition on metabolic activity and community shifts in a microbial consortium. |
| PubMed:Biodegradation of glycerol using bacterial isolates from soil under aerobic conditions. |
| PubMed:FTY720 for cancer therapy (Review). |
| PubMed:Volatile components of essential oil from cultivated Myrica gale var. tomentosa and its antioxidant and antimicrobial activities. |
| PubMed:Glycerol and environmental factors: effects on 1,3-propanediol production and NAD(+) regeneration in Lactobacillus panis PM1. |
| PubMed:Toxicology, occurrence and risk characterisation of the chloropropanols in food: 2-monochloro-1,3-propanediol, 1,3-dichloro-2-propanol and 2,3-dichloro-1-propanol. |
| PubMed:Alkaline conditions stimulate the production of 1,3-propanediol in Lactobacillus panis PM1 through shifting metabolic pathways. |
| PubMed:Influence of oxygen on NADH recycling and oxidative stress resistance systems in Lactobacillus panis PM1. |
| PubMed:Enhanced 1,3-propanediol production by a newly isolated Citrobacter freundii strain cultivated on biodiesel-derived waste glycerol through sterile and non-sterile bioprocesses. |
| PubMed:Isolation and characterization of novel 1,3-propanediol-producing Lactobacillus panis PM1 from bioethanol thin stillage. |
| PubMed:Picea mariana bark: a new source of trans-resveratrol and other bioactive polyphenols. |
| PubMed:Molecular cloning, co-expression, and characterization of glycerol dehydratase and 1,3-propanediol dehydrogenase from Citrobacter freundii. |
| PubMed:Isolation, identification and characterization of human intestinal bacteria with the ability to utilize chloramphenicol as the sole source of carbon and energy. |
| PubMed:Adaptation dynamics of Clostridium butyricum in high 1,3-propanediol content media. |
| PubMed:Isolation process of industrially useful Clostridium bifermentans from natural samples. |
| PubMed:Furan induction of DNA cross-linking and strand breaks in turkey fetal liver in comparison to 1,3-propanediol. |
| PubMed:Enhancement of pH stability and activity of glycerol dehydratase from Klebsiella pneumoniae by rational design. |
| PubMed:Klebsiella spp as a 1, 3-propanediol producer: the metabolic engineering approach. |
| PubMed:Impact of anaerobiosis strategy and bioreactor geometry on the biochemical response of Clostridium butyricum VPI 1718 during 1,3-propanediol fermentation. |
| PubMed:Microbial utilization of crude glycerol for the production of value-added products. |
| PubMed:Rapid NMR method for the quantification of organic compounds in thin stillage. |
| PubMed:Microbiological and chemical characterisation of ting, a sorghum-based sourdough product from Botswana. |
| PubMed:1,3-Propanediol dehydrogenases in Lactobacillus reuteri: impact on central metabolism and 3-hydroxypropionaldehyde production. |
| PubMed:Further investigation into maple syrup yields 3 new lignans, a new phenylpropanoid, and 26 other phytochemicals. |
| PubMed:Production of 1,3-propanediol by Clostridium butyricum growing on biodiesel-derived crude glycerol through a non-sterilized fermentation process. |
| PubMed:Effect of biodiesel-derived waste glycerol impurities on biomass and 1,3-propanediol production of Clostridium butyricum VPI 1718. |
| PubMed:Debottlenecking the 1,3-propanediol pathway by metabolic engineering. |
| PubMed:Influence of environmental parameters on production of the acrolein precursor 3-hydroxypropionaldehyde by Lactobacillus reuteri DSMZ 20016 and its accumulation by wine lactobacilli. |
| PubMed:Industrial biotechnology: tools and applications. |
| PubMed:Novel metabolites from cereal-associated lactobacilli - novel functionalities for cereal products? |
| PubMed:Sugar-glycerol cofermentations by Lactobacillus hilgardii isolated from wine. |
| PubMed:Glycerol metabolism and bitterness producing lactic acid bacteria in cidermaking. |
| PubMed:Crystallization and phase behavior of fatty acid esters of 1,3 propanediol III: 1,3 propanediol dicaprylate/1,3 propanediol distearate (CC/SS) and 1,3 propanediol dicaprylate/1,3 propanediol dipalmitate (CC/PP) binary systems. |
| PubMed:Glycerol induces reuterin production and decreases Escherichia coli population in an in vitro model of colonic fermentation with immobilized human feces. |
| PubMed:Significant lability of guaiacylglycerol beta-phenacyl ether under alkaline conditions. |
| PubMed:Crystallization and phase behavior of 1,3-propanediol esters II. 1,3-propanediol distearate/1,3-propanediol dipalmitate (SS/PP) and 1,3-propanediol distearate/1,3-propanediol dimyristate (SS/MM) binary systems. |
| PubMed:Crystallization and phase behavior of fatty acid esters of 1,3-propanediol I: pure systems. |
| PubMed:Thermal behavior of beta-1 subunits in lignin: pyrolysis of 1,2-diarylpropane-1,3-diol-type lignin model compounds. |
| PubMed:Biogenic amines in natural ciders. |
| PubMed:Stability and comparative metabolism of selected felbamate metabolites and postulated fluorofelbamate metabolites by postmitochondrial suspensions. |
| PubMed:Eicosapentaenoic acid modulates the immune response but has no effect on a mimic of antigen-specific responses. |
| PubMed:Constituents of the leaves of Peucedanum japonicum Thunb. and their biological activity. |
| PubMed:Development of a new method, based on a bioreactor coupled with an L-lactate biosensor, toward the determination of a nonspecific inhibition of L-lactic acid production during milk fermentation. |
| PubMed:3-hydroxypropionaldehyde: applications and perspectives of biotechnological production. |
| PubMed:Purification and structural characterization of 3-hydroxypropionaldehyde and its derivatives. |
| PubMed:Effect of glucose on glycerol bioconversion by Lactobacillus reuteri. |
| PubMed:Production of 1,3-propanediol by Klebsiella pneumoniae. |
| PubMed:Effect of water activity and immobilization on fatty acid selectivity for esterification reactions mediated by lipases. |
| PubMed:Metabolism and distribution of [2,3-(14)C]acrolein in laying hens. |
| PubMed:Glycosides and phenylpropanoid glycerol in vitis vinifera cv. Gewurztraminer wine. |
| PubMed:Biodegradable films from isolate of sunflower (Helianthus annuus) proteins. |
| PubMed:Comparative fatty acid selectivity of lipases in esterification reactions with glycerol and diol analogues in organic media. |
| PubMed:Selectivity of celite-immobilized patatin (lipid acyl hydrolase) from potato (Solanum tuberosum L.) tubers in esterification reactions As influenced by water activity and glycerol analogues as alcohol acceptors. |
| PubMed:Chemicals from biotechnology: molecular plant genetics will challenge the chemical and the fermentation industry. |
| PubMed:Acute, subchronic, and chronic toxicity studies with felbamate, 2-phenyl-1,3-propanediol dicarbamate. |
| PubMed:Cross-linking of starch with bifunctional precursors of nitroalkenes. |
| PubMed:The vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster. |
| PubMed:Determination of 2-ethylhexyl 4-(N-methyl-N-nitrosamino) benzoate in commercial sunscreens and cosmetic products. |
| PubMed:Felbamate pharmacology and use in epilepsy. |
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3D/inchi