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Category:solvents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.33800 @ 25.00 °C.
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| Melting Point: | -30.10 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | 74.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 124.000000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.63 ( Air = 1 ) |
| Flash Point: | 25.00 °F. TCC ( -3.70 °C. ) (est)
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| logP (o/w): | 2.490 |
| Soluble in: |
| | water, 1290 mg/L @ 25 °C (exp) | | | water, 666.1 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-dog LD50 3100 mg/kg
LIVER: LIVER FUNCTION TESTS IMPAIRED
Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.
oral-dog LD50 750 mg/kg
Farm Chemicals Handbook. Vol. -, Pg. C310, 1991.
intravenous-dog LDLo 95 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 72, 1959.
oral-guinea pig LD50 9470 mg/kg
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.
oral-human TDLo 670 mg/kg
GASTROINTESTINAL: OTHER CHANGES
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING
National Technical Information Service. Vol. PB257-185
intraperitoneal-mouse LD50 2568 mg/kg
Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 8, Pg. 371, 1966.
oral-mouse LD50 6000 mg/kg
CARDIAC: PULSE RATE
Gigiena Naselennykh Mest. Hygiene in Populated Places. Vol. 29, Pg. 45, 1990.
oral-rabbit LD50 5660 mg/kg
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.
intraperitoneal-rat LD50 3593 mg/kg
Environmental Research. Vol. 40, Pg. 411, 1986.
oral-rat LD50 9600 mg/kg
CARDIAC: PULSE RATE
Gigiena Naselennykh Mest. Hygiene in Populated Places. Vol. 29, Pg. 45, 1990.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 16000 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: SLEEP
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958.
skin-rabbit LDLo 15800 mg/kg
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.
subcutaneous-rabbit LDLo 500 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 72, 1959.
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| Inhalation Toxicity: |
inhalation-cat LC50 24400 mg/m3
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 35(8), Pg. 127, 1970.
inhalation-human TCLo 920 ppm/70M
SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
American Industrial Hygiene Association Journal. Vol. 19, Pg. 353, 1958.
inhalation-man TCLo 200 ppm/4H
BEHAVIORAL: IRRITABILITY
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Archives of Toxicology, Supplement. Vol. 5, Pg. 96, 1982.
inhalation-man TCLo 200 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
International Archives of Occupational and Environmental Health. Vol. 72, Pg. 485, 1999.
inhalation-man TCLo 350 ppm
BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Work, Environment, Health. Vol. 10, Pg. 82, 1973.
inhalation-mouse LC50 3911 ppm/2H
BEHAVIORAL: EXCITEMENT
Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 13, Pg. 226, 1971.
inhalation-rat LC50 18000 ppm/4H
"Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 28, 1972.
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Safety in Use Information:
| Category: | | solvents |
| Recommendation for 1,1,1-trichloroethane usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for 1,1,1-trichloroethane flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C18246 |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2903.19.5010 |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•usepaopp pesticide code 081201; trade names: methyl chloroform.
•1,1,1-trichloroethane is available commercially in the usa in technical and solvent grades, which differ only in amt of stabilizer added to prevent corrosion of metal parts.
•chlorothene sm, industrial grade
•aerothene tt, aerosol grade
•industrial grade; aerosol grade; general solvent grade, 99.999% grade
•stabilized grades contain 3-8% stabilizers such as nitromethane, n-methylpyrrole butylene oxide, 1,3-dioxolane, and secondary butyl alcohols.
•stabilizing agents which may be present in small amounts include: glycol diesters, ketones, nitriles, dialkyl sulfoxides, dialkyl sulfides, dialkyl sulfites, tetraethyl lead, nitroaliphatic hydrocarbons, 2-methyl-3-butyn-2-ol, tert-butyl alcohol, 1,4-dioxane, dioxolane, sec-butyl alcohol, and monohydric acetylenic alcohols.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | chloroform, methyl- | | | chlorothane NU | | | ethana NU | | | ethane, 1,1,1-trichloro- | | | ethane, trichloro- | | | genklene LB | | | inhibisol | | | methyl chloroform | | | methylchloroform | | | methyltrichloromethane | | | tafclean | | 1,1,1- | TCE | | | trichloro-1,1,1-ethane | | 1,1,1- | trichloroethane | | | trichloromethylmethane |
Articles:
| PubMed:Mitigating pesticide pollution in China requires law enforcement, farmer training, and technological innovation. |
| PubMed:Persistent organic pollutants exposure during pregnancy, maternal gestational weight gain, and birth outcomes in the mother-child cohort in Crete, Greece (RHEA study). |
| PubMed:Ecotoxicity of pp'DDE to Daphnia magna. |
| PubMed:Occurrence and biomagnification of organohalogen pollutants in two terrestrial predatory food chains. |
| PubMed:Residue levels of organochlorine pesticides in cattle meat and organs slaughtered in selected towns in West Shoa Zone, Ethiopia. |
| PubMed:Evaluation of substrate removal kinetics for UASB reactors treating chlorinated ethanes. |
| PubMed:Development and application of an indirect competitive enzyme-linked immunosorbent assay for the detection of p,p'-DDE in human milk and comparison of the results against GC-ECD. |
| PubMed:Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems. |
| PubMed:Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455). |
| PubMed:Dietary exposure to persistent organochlorine pesticides in 2007 Chinese total diet study. |
| PubMed:Concentrations of trace elements [corrected] and organochlorines in Mutton bird (Puffinus griseus). |
| PubMed:[Safety verification for reuse of PET and glass bottles]. |
| PubMed:Contaminant pattern and bioaccumulation of legacy and emerging organhalogen pollutants in the aquatic biota from an e-waste recycling region in South China. |
| PubMed:Determination of lead, cadmium, and persistent organic pollutants in wild and orchard-farm-grown fruit in northeastern Poland. |
| PubMed:Environmental factors in genitourinary development. |
| PubMed:Identification of methylmercury tolerance gene candidates in Drosophila. |
| PubMed:Multiresidue pesticide analysis of ginseng powders using acetonitrile- or acetone-based extraction, solid-phase extraction cleanup, and gas chromatography-mass spectrometry/selective ion monitoring (GC-MS/SIM) or -tandem mass spectrometry (GC-MS/MS). |
| PubMed:A historical assessment of coastal contamination in Birch Harbor, Maine based on the analysis of mussels collected in the 1940s and the Mussel Watch Program. |
| PubMed:Transport and release of chemicals from plastics to the environment and to wildlife. |
| PubMed:Bacillus thuringiensis (Bt) transgenic crop: an environment friendly insect-pest management strategy. |
| PubMed:Final report on the safety assessment of Trichloroethane. |
| PubMed:Analysis of environmental chemical residues in products of emerging aquaculture industry in Uganda as case study for Sub-Saharan Africa. |
| PubMed:Organic pollutants in areas impacted by flooding in 2002: a 4-year survey. |
| PubMed:Polychlorinated biphenyls, organochlorine pesticides and neurodevelopment. |
| PubMed:Fish from industrially polluted freshwater as the main source of organochlorinated pollutants and increased frequency of thyroid disorders and dysglycemia. |
| PubMed:Organochlorine exposures during pregnancy and infant size at birth. |
| PubMed:Association of serum concentration of organochlorine pesticides with dietary intake and other lifestyle factors among urban Chinese women. |
| PubMed:A worldwide survey of polychlorinated dibenzo-p-dioxins, dibenzofurans, and related contaminants in butter. |
| PubMed:Pesticide and pathogen contamination of vegetables in Ghana's urban markets. |
| PubMed:Trends of chlorinated organic contaminants in great lakes trout and walleye from 1970 to 1998. |
| PubMed:Effect of cooking on the loss of persistent organic pollutants from salmon. |
| PubMed:[Analysis of residual solvents in natural flavorings by headspace GC using the standard addition method]. |
| PubMed:Persistent organic pollutants and heavy metals in typical seafoods consumed in Singapore. |
| PubMed:[Chemical-toxicological characteristic property of organochlorine pesticide transformation products formed under the effect of intensive fluxes of gamma-irradiation]. |
| PubMed:VOC removal from contaminated groundwater through membrane pervaporation. (II): 1,1,1-trichloroethane-SDS surfactant solution system. |
| PubMed:VOC removal from contaminated groundwater through membrane pervaporation. (I): Water-1,1,1-trichloroethane system. |
| PubMed:Current internal exposure to pesticides in children and adolescents in Germany: blood plasma levels of pentachlorophenol (PCP), lindane (gamma-HCH), and dichloro(diphenyl)ethylene (DDE), a biostable metabolite of dichloro(diphenyl)trichloroethane (DDT). |
| PubMed:Residues of DDT and HCH pesticides in rice samples from different geographical regions of India: a multicentre study. |
| PubMed:Time trends of persistent organic pollutants and heavy metals in umbilical cord blood of Inuit infants born in Nunavik (Québec, Canada) between 1994 and 2001. |
| PubMed:Adsorption of volatile organic compounds by pecan shell- and almond shell-based granular activated carbons. |
| PubMed:Concentrations and hazard assessment of PCBs, organochlorine pesticides and mercury in fish species from the Upper Thames: river pollution and its potential effects on top predators. |
| PubMed:Organochlorine pesticides and polychlorinated biphenyls in 12 edible marine organisms from the Adriatic Sea, Italy, Spring 1997. |
| PubMed:Dietary and reproductive factors associated with benign breast disease in Mexican women. |
| PubMed:A survey on organochlorine pesticide residues in butter and cracked wheat available in Turkish markets. |
| PubMed:Influence of the consumption of fatty Baltic Sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men. |
| PubMed:Intercellular communication and cell proliferation in precision-cut rat liver slices: effect of medium composition and DDT. |
| PubMed:Developmental effects of intermittent prenatal exposure to 1,1,1-trichloroethane in the rat. |
| PubMed:Agricultural produce in the dry bed of the River Ganga in Kanpur, India--a new source of pesticide contamination in human diets. |
| PubMed:National human exposure assessment survey (NHEXAS): exploratory survey of exposure among population subgroups in EPA Region V. |
| PubMed:Levels of dichloro-dyphenyl-trichloroethane (DDT) metabolites in maternal milk and their determinant factors. |
| PubMed:Some dietary predictors of plasma organochlorine concentrations in an elderly German population. |
| PubMed:Genotoxic changes after low-level solvent and fuel exposure on aircraft maintenance personnel. |
| PubMed:Desflurane, enflurane, isoflurane and ether produce ethanol-like discriminative stimulus effects in mice. |
| PubMed:Development of a priority list of chemical mixtures occurring at 1188 hazardous waste sites, using the HazDat database. |
| PubMed:Increased concentrations of octachlorodibenzo-p-dioxin in cases with breast cancer--results from a case-control study. |
| PubMed:Michigan's fisheater cohorts: a prospective history of exposure. |
| PubMed:Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures. |
| PubMed:Chemical contaminants, pharmacokinetics, and the lactating mother. |
| PubMed:The pharmacokinetics of inhaled 1,1,1-trichloroethane following high milk intake in mice. |
| PubMed:Determinants of polychlorinated biphenyls (PCBs) in the sera of mothers and children from Michigan farms with PCB-contaminated silos. |
| PubMed:Assessment of location-specific human exposure to dichloro-diphenyl trichloroethane and benzenehexachloride in Gujarat state, India. |
| PubMed:Evaluation of daily dietary intake of dichloro-diphenyl-trichloroethane (DDT) and benzene hexachloride (BHC) in India. |
| PubMed:Determination of volatile chemicals released from microwave-heat-susceptor food packaging. |
| PubMed:Blood levels of organochlorine residues and risk of breast cancer. |
| PubMed:Organochlorine pesticide residues in different Indian cereals, pulses, spices, vegetables, fruits, milk, butter, Deshi ghee, and edible oils. |
| PubMed:Health risk assessment of environmental exposure to 1,1,1-trichloroethane. |
| PubMed:Determinants of polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyl trichloroethane (DDT) levels in the sera of young children. |
| PubMed:Exposure of Japanese quail embryos to o,p'-DDT has long-term effects on reproductive behaviors, hematology, and feather morphology. |
| PubMed:Rapid determination of fumigant and industrial chemical residues in food. |
| PubMed:Residues of volatile halocarbons in margarines. |
| PubMed:Organochlorine pesticide residues in chicken eggs: a survey. |
| PubMed:Human exposure to volatile halogenated hydrocarbons from the general environment. |
| PubMed:Influence of diet and other factors on the levels of organochlorine compounds in human adipose tissue in Finland. |
| PubMed:Brine shrimp (Artemia salina) nauplii as a teratogen test system. |
| PubMed:Gas chromatographic determination of 1,1,1-trichloroethane in vinyl chloride polymers and in foods. |
| PubMed:The occurrence and origin of DDT in human milk. |
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3D/inchi