(S,R)-noscapine
8-methoxyhydrastin

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  CODE114258 CODE114258
  Product(s):
  128-62-1 Noscapine >98%
  Noscapine is a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine binds to tubulin and alters its conformation, resulting in a disruption of

CAS Number: 128-62-1 3D/inchi Other(deleted CASRN): 1368-39-4 ECHA EINECS - REACH Pre-Reg: 204-899-2 FDA UNII: 8V32U4AOQU Nikkaji Web: J9.283E Beilstein Number: 0099933 MDL: MFCD00069316 XlogP3-AA: 2.70 (est) Molecular Weight: 413.42671000 Formula: C22 H23 N O7 NMR Predictor: Predict (works with chrome, Edge or firefox) Category:natural substances and extractives   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Soluble in:   water, 300mg/L @ 30 °C (exp)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Noscapine >98% Odor: characteristic Use: Noscapine is a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic activities. Noscapine binds to tubulin and alters its conformation, resulting in a disruption of Santa Cruz Biotechnology For experimental / research use only. Noscapine ≥99% Sigma-Aldrich: Aldrich For experimental / research use only. (S,R)-Noscapine 97% sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intravenous-dog LDLo 73200 ug/kg SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 323, 1968. intraperitoneal-mouse LD50 960 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982. intravenous-mouse LD50 83 mg/kg Toxicology and Applied Pharmacology. Vol. 3, Pg. 96, 1961. oral-mouse LD50 853 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982. oral-rat LD50 1520 mg/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2331, 1982. Dermal Toxicity: subcutaneous-mouse LD50 725 mg/kg Russian Pharmacology and Toxicology Vol. 31, Pg. 338, 1968. Inhalation Toxicity: Not determined   Safety in Use Information: Category: natural substances and extractives Recommendation for (S,R)-noscapine usage levels up to:   not for fragrance use.   Recommendation for (S,R)-noscapine flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :275196 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one Chemidplus:0000128621 RTECS:RD2625000 for cas# 128-62-1   References:   (3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 128-62-1 Pubchem (cid): 275196 Pubchem (cas): 128-62-1   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View KEGG (GenomeNet): C09592 HMDB (The Human Metabolome Database): HMDB33439 FooDB: FDB011477 Export Tariff Code: 2939.10.5000 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View EFSA Update of results on the monitoring of furan levels in food: Read Report EFSA Previous report: Results on the monitoring of furan levels in food: Read Report EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   poppy opium poppy Search Trop Picture   Synonyms: 1(3H)-iso benzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo(4,5-g)-isoquinolin-5-yl), (S-(R*,S*))- (3S)-6,7- dimethoxy-3-[(5R)-4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3H-2-benzofuran-1-one 8- methoxyhydrastin (-)-3-(2- methyl-6,7-methylendioxy-8-methoxy-1-isochinolyl)-6,7-dimethoxyphthalid   narcotine (8CI)   Articles:   None found yet. Try the PubMed Search.

Notes: Alkaloid from Papaver somniferum (opium poppy) Noscapine (also known as Narcotine, Nectodon, Nospen, and Anarcotine) is a benzylisoquinoline alkaloid from plants of the Papaveraceae family, without significant painkilling properties. This agent is primarily used for its antitussive (cough-suppressing) effects. It has also been shown to have anticancer activity. (Wikipedia)