laudanosine, 1699-51-0

Articles:

PubMed:[Determination of atracurium and laudanosine in dog plasma during cardiopulmonary bypass by high performance liquid chromatography with fluorometric detection].

PubMed:Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine.

PubMed:Synthesis of alkaloids by Stevens rearrangement of nitrile-stabilized ammonium ylides: (±)-laudanosine, (±)-laudanidine, (±)-armepavine, (±)-7-methoxycryptopleurine, and (±)-xylopinine.

PubMed:Laudanosine has no effects on respiratory activity but induces non-respiratory excitement activity in isolated brainstem-spinal cord preparation of neonatal rats.

PubMed:Methyl-laudanosine: a new pharmacological tool to investigate the function of small-conductance Ca(2+)-activated K(+) channels.

PubMed:Modulation of rat brain synaptosomal plasma membrane achieved by atracurium and its metabolite laudanosine.

PubMed:Laudanosine and atracurium concentrations in a patient receiving long-term atracurium infusion.

PubMed:Mechanism of the cardiovascular activity of laudanosine: comparison with papaverine and other benzylisoquinolines.

PubMed:Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.

PubMed:Convulsive effects and pharmacokinetics of laudanosine in the rat.

PubMed:Pharmacology of laudanosine in dogs.

PubMed:Laudanosine (a metabolite of atracurium) increases the minimum alveolar concentration of halothane in rabbits.

PubMed:Suicide with cisatracurium and thiopental: forensic and analytical aspects.

PubMed:Pharmacokinetic modelling of a parent drug and its metabolite. Atracurium and laudanosine.

PubMed:Atracurium decay and the formation of laudanosine in humans.

PubMed:Cardiovascular and neurological effects of laudanosine. Studies in mice and rats, and in conscious and anaesthetized dogs.

PubMed:Electrophysiological characterization of the SK channel blockers methyl-laudanosine and methyl-noscapine in cell lines and rat brain slices.

PubMed:Effect of atracurium and laudanosine on the release of 3H-noradrenaline.

PubMed:[Effect of laudanosine on catecholamine release in dogs].

PubMed:Cardiovascular and electroencephalographic effects of laudanosine in "nephrectomized" cats.

PubMed:Cerebrospinal fluid concentrations of atracurium, laudanosine and vecuronium following clinical subarachnoid hemorrhage.

PubMed:Pharmacodynamics and atracurium and laudanosine concentrations during a fixed continuous infusion of atracurium in mechanically ventilated patients with acute respiratory distress syndrome.

PubMed:Laudanosine, an atracurium and cisatracurium metabolite.

PubMed:Cerebrospinal fluid concentrations of laudanosine after administration of atracurium.

PubMed:Electroencephalographic effects of laudanosine in an animal model of epilepsy.

PubMed:Modification by drugs used in anaesthesia of CNS stimulation induced in mice by laudanosine and strychnine.

PubMed:Clearance of atracurium and laudanosine in the urine and by continuous venovenous haemofiltration.

PubMed:Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma during intracranial surgery.

PubMed:Laudanosine does not displace receptor-specific ligands from the benzodiazepinergic or muscarinic receptors.

PubMed:Blockade and activation of the human neuronal nicotinic acetylcholine receptors by atracurium and laudanosine.

PubMed:Plasma laudanosine levels in patients given atracurium during liver transplantation.

PubMed:Concentrations of atracurium and laudanosine in cerebrospinal fluid and plasma in three intensive care patients.

PubMed:Pharmacokinetics of atracurium and laudanosine in the elderly.

PubMed:Disposition of infusions of atracurium and its metabolite, laudanosine, in patients in renal and respiratory failure in an ITU.

PubMed:Synthesis and biological evaluation of N-methyl-laudanosine iodide analogues as potential SK channel blockers.

PubMed:Plasma concentrations of laudanosine, but not of atracurium, are increased during the anhepatic phase of orthotopic liver transplantation in pigs.

PubMed:The distribution of laudanosine in tissues after death from atracurium injection.

PubMed:High-performance liquid chromatographic method for the determination of atracurium and laudanosine in human plasma. Application to pharmacokinetics.

PubMed:Transplacental distribution of atracurium, laudanosine and monoquaternary alcohol during elective caesarean section.

PubMed:High-performance liquid chromatographic assay for laudanosine in biological fluids and tissue for neurotoxic studies in rats.

PubMed:Modification of central nervous system effects of laudanosine by inhalation anaesthetics.

PubMed:Pharmacokinetics of atracurium and laudanosine in patients with hepatic cirrhosis.

PubMed:The metabolic disposition of laudanosine in dog, rabbit, and man.

PubMed:[Absorption of papaverine, laudanosine and cepharanthine across human intestine by using human Caco-2 cells monolayers model].

PubMed:Nitrous oxide antagonizes CNS stimulation by laudanosine in mice.

PubMed:Production of laudanosine following infusion of atracurium in man and its effects on awakening.

PubMed:Effect of renal failure on laudanosine excretion in man.

PubMed:Pharmacokinetics of 1R-cis 1'R-cis atracurium besylate (51W89) and plasma laudanosine concentrations in health and chronic renal failure.

PubMed:Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine.

PubMed:Clinical experience and plasma laudanosine concentrations during the infusion of atracurium in the intensive therapy unit.

PubMed:Simultaneous determination of atracurium and its metabolite laudanosine in post-mortem fluids by liquid chromatography/multiple-stage mass spectrometry on an ion trap.

PubMed:Chiral separation of norlaudanosoline, laudanosoline, laudanosine, chlorthalidone, and three benzoin derivatives using amino acid based molecular micelles.

PubMed:Identification of laudanosine, an atracurium metabolite, following a fatal drug-related shooting.

PubMed:Hepatotoxicity testing of atracurium and laudanosine in the isolated, perfused rat liver.

PubMed:Determination of atracurium and laudanosine in human plasma by high-performance liquid chromatography.

PubMed:The microbial oxygenation of the benzylisoquinoline alkaloid laudanosine.

PubMed:Atracurium and laudanosine pharmacokinetics in acute renal failure.

PubMed:Simplified method for the determination of atracurium and laudanosine in pig plasma by high-performance liquid chromatography and fluorimetric detection.

PubMed:The possible neuroprotective effect of laudanosine, an atracurium and cisatracurium metabolite.

PubMed:High-dose laudanosine enhances liver cell activity and bile flow during reperfusion of the liver.

PubMed:Determination of atracurium, laudanosine and related compounds in plasma by high-performance liquid chromatography.

PubMed:The use of cisatracurium in critical care: A review of the literature.

PubMed:Investigation of chondroitin sulfate D and chondroitin sulfate E as novel chiral selectors in capillary electrophoresis.

PubMed:[DEHYDRATION OF TERTIARY AMINES WITH HG(II)-EDTA. 8. ON THE CONFIGURATION OF 1-BENZYL-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE AND LAUDANOSINE].

PubMed:[Dehydration of tertiary amines by mercuric acetate in the presence of ethylenediaminetetraacetic acid. 1. The configuration of laudanosine].

PubMed:Microbial transformations of natural antitumor agents. 2. Studies with d-tetrandrine and laudanosine.

PubMed:[DEHYDROGENATION OF TERTIARY AMINES WITH HG(II)-EDTA. 6. FURTHER STUDIES ON THE PROCESS OF AROMATIZATION OF LAUDANOSINE WITH HG(III)-EDTA].

PubMed:[Dehydration of tertiary amines with Hg(II)-EDTA. 4. On the course of aromatization of laudanosine with Hg(II)-EDTA].

PubMed:Characterization of three O-methyltransferases involved in noscapine biosynthesis in opium poppy.

PubMed:Synthesis and radioligand binding studies of bis-(8-isopropyl-isoquinolinium) derivatives as ligands for apamin-sensitive sites on cloned SK2 and SK3 channels.

PubMed:Atracurium infusions in patients with fulminant hepatic failure awaiting liver transplantation.

PubMed:Anesthesiologist suicide with atracurium.

PubMed:The in vitro degradation of cisatracurium, the R, cis-R'-isomer of atracurium, in human and rat plasma.

PubMed:The biosynthesis of papaverine proceeds via (S)-reticuline.

PubMed:Enantioselective synthesis of tetrahydroprotoberberines and bisbenzylisoquinoline alkaloids from a deprotonated α-aminonitrile.

PubMed:Identification and quantitation of six non-depolarizing neuromuscular blocking agents by LC-MS in biological fluids.

PubMed:Pharmacokinetics and dynamics of atracurium infusions after paediatric orthotopic liver transplantation.

PubMed:Determination of atracurium, cisatracurium and mivacurium with their impurities in pharmaceutical preparations by liquid chromatography with charged aerosol detection.

PubMed:Perinatal neuroprotection by muscle relaxants against hypoxic-ischemic lesions: is it a possible hypothesis?

PubMed:Evaluation of the enantioselectivity of glycogen-based dual chiral selector systems towards basic drugs in capillary electrophoresis.

PubMed:Comparison of the pharmacodynamics and pharmacokinetics of an infusion of cis-atracurium (51W89) or atracurium in critically ill patients undergoing mechanical ventilation in an intensive therapy unit.

PubMed:In vitro degradation of atracurium in human plasma.

PubMed:The pharmacokinetics of cisatracurium in patients with acute respiratory distress syndrome.

PubMed:Effects of neuromuscular blocking agents on excitatory transmission and gamma-aminobutyric acidA-mediated inhibition in the rat hippocampal slice.

PubMed:Pharmacokinetics of cisatracurium in patients receiving nitrous oxide/opioid/barbiturate anesthesia.

PubMed:The prolonged use of atracurium in a patient with tetanus.

PubMed:Pharmacokinetics of atracurium and its metabolites in patients with normal renal function, and in patients in renal failure.

PubMed:Pharmacophore modelling of structurally unusual diltiazem mimics at L-type calcium channels.

PubMed:A comparison of the infusion pharmacokinetics and pharmacodynamics of cisatracurium, the 1R-cis 1'R-cis isomer of atracurium, with atracurium besylate in healthy patients.

PubMed:A pharmacokinetic-pharmacodynamic model for a muscle relaxant: atracurium.

PubMed:Pharmacokinetics of 51W89: preliminary data.

PubMed:Atracurium-induced neuromuscular block in the isolated arm.

PubMed:Pharmacokinetics and neuromuscular blocking effects of atracurium besylate and two of its metabolites in patients with normal and impaired renal function.

PubMed:The pharmacokinetics and pharmacodynamics of atracurium in patients with and without renal failure.

PubMed:Synthesis of carbon-11 labeled 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinolinium derivatives as new potential PET SKCa channel imaging agents.

PubMed:Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers.

PubMed:Risk-based approach for the transfer of quantitative methods: bioanalytical applications.

PubMed:SK channels control the firing pattern of midbrain dopaminergic neurons in vivo.

PubMed:Studies of polymerized sodium N-undecylenyl-L-valinate in chiral micellar electrokinetic capillary chromatography of neutral, acidic, and basic compounds.

PubMed:Pharmacokinetics and pharmacodynamics of cisatracurium in patients with end-stage liver disease undergoing liver transplantation.

PubMed:Lambda-carrageenan: a novel chiral selector for capillary electrophoresis.

PubMed:Influence of extreme obesity on the body disposition and neuromuscular blocking effect of atracurium.

PubMed:Prolonged infusion of atracurium in an infant.

PubMed:Atracurium overdose in a small infant.

PubMed:Generation of reactive metabolites during spontaneous degradation of atracurium in vitro.

PubMed:Pharmacokinetics of atracurium in anaesthetized infants and children.

PubMed:Relationships between structure and vascular activity in a series of benzylisoquinolines.

PubMed:Activation of brain acetylcholine receptors by neuromuscular blocking drugs. A possible mechanism of neurotoxicity.

PubMed:Influence of incubated atracurium on rat liver function.

PubMed:Residual curarization in the neonate after caesarean section.

PubMed:Pharmacokinetics and pharmacodynamics of atracurium obtained with arterial and venous blood samples.

PubMed:Anaesthesia for the treatment of a giant cerebral aneurysm under hypothermic circulatory arrest.

PubMed:Synthesis and radioligand binding studies of methoxylated 1,2,3,4-tetrahydroisoquinolinium derivatives as ligands of the apamin-sensitive Ca2+-activated K+ channels.

PubMed:The efficient synthesis of morphinandienone alkaloids by using a combination of hypervalent iodine(III) reagent and heteropoly acid.

PubMed:Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain.

PubMed:Effect of dopamine, dimethoxyphenylethylamine, papaverine, and related compounds on mitochondrial respiration and complex I activity.

PubMed:Identification of urinary and biliary conjugated metabolites of the neuromuscular blocker 51W89 by liquid chromatography/mass spectrometry.

PubMed:Selective inhibition of calcium entry induced by benzylisoquinolines in rat smooth muscle.

PubMed:The cardiovascular effects of atracurium and it's metabolite.

PubMed:Pharmacological action of breakdown products of atracurium and related substances.

PubMed:Cisatracurium infusion for neuromuscular blockade in the pediatric intensive care unit: A dose-finding study.

PubMed:Applicability of ultra-performance liquid chromatography-tandem mass spectrometry for heroin profiling.

PubMed:Bioactive constituents of the roots of Polyalthia cerasoides.

PubMed:Evaluation of benzyltetrahydroisoquinolines as ligands for neuronal nicotinic acetylcholine receptors.

PubMed:Transformation of opium poppy (Papaver somniferum L.) with antisense berberine bridge enzyme gene (anti-bbe) via somatic embryogenesis results in an altered ratio of alkaloids in latex but not in roots.

PubMed:The GC-MS detection and characterization of reticuline as a marker of opium use.

PubMed:Instability of pancuronium in postmortem blood and liver taken after a fatal intramuscular Pavulon injection.

PubMed:The GC-MS detection and characterization of reticuline as a marker of opium use.

PubMed:Aporphine alkaloids from Guatteria spp. with leishmanicidal activity.

PubMed:Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.

PubMed:Colominic acid: a novel chiral selector for capillary electrophoresis of basic drugs.

PubMed:Pharmacokinetic-pharmacodynamic modeling of atracurium in intensive care patients.

PubMed:Approaching a million-fold sensitivity increase in capillary electrophoresis with direct ultraviolet detection: cation-selective exhaustive injection and sweeping

PubMed:Comparative evaluation of capillary electrophoresis and high-performance liquid chromatography for the separation of cis-cis, cis-trans, and trans-trans isomers of atracurium besylate.

PubMed:[Cisatracurium].

PubMed:[The clinical pharmacology of new benzylisoquinoline-diester compounds, with special consideration of cisatracurium and mivacurium].

PubMed:[New muscle relaxants].

PubMed:Approaches to short-acting neuromuscular blocking agents: nonsymmetrical bis-tetrahydroisoquinolinium mono- and diesters.

PubMed:Simple high-performance liquid chromatographic method for the analysis of the non-depolarizing neuromuscular blocking drugs in clinical anaesthesia.

PubMed:Pharmacokinetics of atracurium metabolites.

PubMed:Review of atracurium by continuous i.v. infusion.

PubMed:High pressure liquid chromatographic determination of the five major alkaloids in Papaver somniferum L. and thebaine in Papaver bracteatum Lindl. capsular tissue.

PubMed:Hofmann elimination with diazomethane on curare bases and selected quaternary tetrahydroisoquinoline alkaloids.

PubMed:A relatively simple differential screening test for GABA or glycine antagonists using rat electroretinography.

PubMed:Alkaloids of Hernandia voyronii: chloroquine-potentiating activity and structure elucidation of herveline D.

PubMed:Neutral heroin impurities from tetrahydrobenzylisoquinoline alkaloids.

PubMed:The roles of latex and the vascular bundle in morphine biosynthesis in the opium poppy, Papaver somniferum.

PubMed:The insulin pump as murder weapon: a case report.

PubMed:Does ester hydrolysis change the in vitro degradation rate of cisatracurium and atracurium?

PubMed:Concentration-effect relationship of cisatracurium at three different dose levels in the anesthetized patient.

PubMed:[Effects of priming technique on onset profile of cisatracurium].

PubMed:In vitro degradation of atracurium and cisatracurium at pH 7.4 and 37 degrees C depends on the composition of the incubating solutions.

PubMed:Importance of the organ-independent elimination of cisatracurium.

PubMed:Simultaneous determination of dextrorphan and guaifenesin in human plasma by liquid chromatography with fluorescence detection.

PubMed:Is 51W89 an improvement compared with atracurium?

PubMed:Inhibition of purine nucleobase transport in human erythrocytes and cell lines by papaverine. Investigation of structure-activity relationship.

PubMed:Simple and rapid high-performance liquid chromatography method for the determination of alcuronium in human plasma and urine.

PubMed:Inhibition of hepatic microsomal drug metabolism by atracurium administration in the rat.

PubMed:Separation of eight alkaloids and meconic acid and quantitation of five principal alkaloids in gum opium by gradient reversed-phase high-performance liquid chromatography.

PubMed:Effects of atracurium, vecuronium or pancuronium pretreatment on lignocaine seizure thresholds in cats.

PubMed:Preponderance of hydrolysis in inactivation of atracurium: questions remain.

PubMed:Status epilepticus following enflurane anaesthesia.

PubMed:Atracurium infusions in patients with renal failure on an ITU.

PubMed:Pharmacokinetics of atracurium and its metabolites.

PubMed:Atracurium: an overview.

PubMed:The cerebral effects of pancuronium and atracurium in halothane-anesthetized dogs.

PubMed:Magic bullets, science, and medicine.

PubMed:[Metabolism and pharmacokinetics of atracurium].

PubMed:Stereochemical preferences for curarimimetic neuromuscular junction blockade IV: Monoquaternary ammonium probes possessing carbon and nitrogen asymmetry.

PubMed:Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes.

laudanosine

Supplier Sponsors

Articles: