EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

methoxyisopropanol
propylene glycol monomethyl ether

Supplier Sponsors

Name:1-methoxypropan-2-ol
CAS Number: 107-98-2Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-539-1
FDA UNII: 74Z7JO8V3U
Nikkaji Web:J22.127I
Beilstein Number:1731270
MDL:MFCD00004537
XlogP3-AA:-0.20 (est)
Molecular Weight:90.12210000
Formula:C4 H10 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.92200 @ 25.00 °C.
Melting Point: 119.00 °C. @ 760.00 mm Hg
Boiling Point: 119.00 °C. @ 760.00 mm Hg
Vapor Pressure:8.152000 mmHg @ 25.00 °C. (est)
Flash Point: 93.00 °F. TCC ( 33.89 °C. )
logP (o/w): -0.342 (est)
Soluble in:
 alcohol
 water, 1000000 mg/L @ 25 °C
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: perfuming agents
solvents
 
Suppliers:
BOC Sciences
For experimental / research use only.
1-Methoxy-2-propanol 95%
Charkit Chemical
ALNOVOL SPN 402
Eastman Chemical
PM Solvent
99.0 wt % min.
ECSA Chemicals
PM (DOWANOL) PROPYLENEGLYCOL MONOMETHYLETHER
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Penta International
1-METHOXY-2-PROPANOL
Silver Fern Chemical
Glycol Ether PM
Odor: characteristic
Use: Glycol Ether PM offers very high water solubility and active solvency, and is widely used in coating and cleaning applications. It offers better viscosity reduction than heavier molecular weight glycol ethers and is particularly effective in epoxy and high solids acrylic systems.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3739 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0520402

intravenous-rat LD50 4200 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

intraperitoneal-rat LD50 3720 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 3977, 1982.

oral-rabbit LD50 5700 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

intravenous-dog LD50 2000 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

oral-dog LD50 5000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

intraperitoneal-mouse LD > 500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 4, Pg. 110, 1952.

intravenous-mouse LD50 5300 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

oral-mouse LD50 11700 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

intravenous-rabbit LD50 1200 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

Dermal Toxicity:
skin-rabbit LD50 13000 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.

subcutaneous-rat LD50 7800 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

subcutaneous-rabbit LD50 5000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 22, Pg. 569, 1972.

Inhalation Toxicity:
inhalation-rat LC50 10000 ppm/5H
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.

inhalation-guinea pig LCLo 15000 ppm/7H
BEHAVIORAL: SLEEP
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 509, 1954.

inhalation-human TCLo 3000 ppm
GASTROINTESTINAL: NAUSEA OR VOMITING SENSE ORGANS AND SPECIAL SENSES: TUMORS: OLFACTION BEHAVIORAL: GENERAL ANESTHETIC
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 105, 1974.

inhalation-rabbit LCLo 15000 ppm/7H
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 9, Pg. 509, 1954.

 
Safety in Use Information:
Category:
cosmetic and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
 
Recommendation for methoxyisopropanol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):107-98-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7900
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1-methoxypropan-2-ol
Chemidplus:0000107982
EPA/NOAA CAMEO:hazardous materials
RTECS:107-98-2
 
References:
 1-methoxypropan-2-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:107-98-2
Pubchem (cid):7900
Pubchem (sid):134972745
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2909.49.5000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•dowanol pm typically contains 97% (min) 1-methoxy-2-propanol and 3% (max) 2-methoxy-1-propanol •representative floor cleaner (wt %): dowanol pm glycol ether 14, water 58, oleic acid 16, triethanolamine 12 •representative glass cleaner (wt %): dowanol pm glycol ether 8, water 90.4, ammonium hydroxide (28%) 1.5, surfactant 0.1; dowanol pm glycol ether 5, water 55, isopropanol 35, propylene glycol 5 •representative aerosol window (foam-type) cleaner (wt %): dowanol pm glycol ether 5, water 85.85, colloidal silica 4, surfactants 0.15 •representative graffiti remover (wt %): dowanol pm glycol ether 40-50, dowanol db glycol ether 30-40, pine oil or isopropanol 10-20 •representative leather, vinyl, plastic cleaner (wt %): dowanol pm glycol ether 5, water 81.5, isopropanol 2.5, amyl acetate 1.0, igepal co-630 10.0 •representative windshield washer formulation for winter use (wt %): dowanol pm glycol ether 12, propylene glycol 12, isopropanol 76 •representative floor wax stripper (wt %): dowanol pm glycol ether 8, water 81, trisodium phosphate 2.5, triton x-100 surfactant 8.5 •trade names: arcosolv pm, dowanol pm glycol ether, methyl proxitol, propasol solvent m, poly-solv mpm solvent.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dowanol 33B
 glycol ether PM
1-methoxy-1-methylethanol
2-methoxy-1-methylethanol
1-methoxy-2-hydroxypropane
(±)-1-methoxy-2-propanol
1-methoxy-2-propanol
1-methoxypropan-2-ol
 methyl proxitol
 PGME
 PM solvent
 poly-solve MPM
2-propanol, 1-methoxy-
 propasol solvent M
 propylene glycol 1-methyl ether
 propylene glycol methyl ether
 propylene glycol monomethyl ether
 propyleneglycol monomethyl ether
 

Articles:

PubMed:Surfactant toxicity in a case of (4-chloro-2-methylphenoxy) acetic acid herbicide intoxication.
PubMed:Optimization of reactive simulated moving bed systems with modulation of feed concentration for production of glycol ether ester.
PubMed:Sex differences in urinary levels of several biological indicators of exposure: a simulation study using a compartmental-based toxicokinetic model.
PubMed:Evaluation of the solvent black 3 fingermark enhancement reagent: part 2 - investigation of the optimum formulation and application parameters.
PubMed:Evaluation of the solvent black 3 fingermark enhancement reagent: part 1 - investigation of fundamental interactions and comparisons with other lipid-specific reagents.
PubMed:Sex differences in urinary levels of several biological indicators of exposure: a human volunteer study.
PubMed:Authentication of fattening diet of Iberian pigs according to their volatile compounds profile from raw subcutaneous fat.
PubMed:Use of read-across and tiered exposure assessment in risk assessment under REACH--a case study on a phase-in substance.
PubMed:Sensitive headspace gas chromatography analysis of free and conjugated 1-methoxy-2-propanol in urine.
PubMed:Determining indoor air quality and identifying the origin of odour episodes in indoor environments.
PubMed:Biological treatment of a contaminated gaseous emission from a leather industry in a suspended-growth bioreactor.
PubMed:Biomonitoring as a tool in the human health risk characterization of dermal exposure.
PubMed:Constituents from Hoya parasitica and their cell growth inhibitory activity.
PubMed:Passive sampling of glycol ethers and their acetates in indoor air.
PubMed:Investigations of reaction kinetics for immobilized enzymes--identification of parameters in the presence of diffusion limitation.
PubMed:A kinetic study of lipase-catalyzed reversible kinetic resolution involving verification at miniplant-scale.
PubMed:Evaluation of exposure to 1-alkoxy-2-propanols and 1-(2-methoxy-1-methylethoxy)-2-propanol by the analysis of the parent compounds in urine.
PubMed:Oxidation of ABTS by silicate-immobilized cytochrome c in nonaqueous solutions.
PubMed:Propylene glycol monomethyl ether occupational exposure (PGME). 4. Analysis of 2-methoxypropionic acid in urine.
PubMed:Factors affecting the extent of dermal absorption of solvent vapours: a human volunteer study.
PubMed:Biodegradation of VOCs from printing press air by an on-site pilot plant bioscrubber and laboratory scale continuous yeast cultures.
PubMed:Effects of experimental conditions on absorption of glycol ethers through human skin in vitro.
PubMed:Dermal uptake of solvents from the vapour phase: an experimental study in humans.
PubMed:Biological monitoring of occupational exposure to 1-methoxy-2-propanol.
PubMed:A novel device for capturing breath samples for solvent analysis.
PubMed:Biomonitoring of technical grade 1-alkoxy-2-propanol acetates by analysing urinary 2-alkoxypropionic acids.
PubMed:A biological monitoring study of 1-methoxy-2-propanol: analytical method development and a human volunteer study.
PubMed:Determination of 1-methoxy-2-propanol and its metabolite 1,2-propanediol in rat and mouse plasma by gas chromatography.
PubMed:Chronic occupational exposure to organic solvents. XV. Glycol ether exposure during the manufacture of brakehoses.
PubMed:Liquid/air partition coefficients of six commonly used glycol ethers.
PubMed:Absorption of some glycol ethers through human skin in vitro.
 
Notes:
None found
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