|
Category:nutrient supplements
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
| Melting Point: | 84.00 to 85.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 496.44 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 418.00 °F. TCC ( 214.20 °C. ) (est)
|
| logP (o/w): | 9.085 (est) |
| Soluble in: |
| | water, 2.224e-005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 42 mg/kg
Toxicology and Applied Pharmacology. Vol. 43, Pg. 125, 1978.
oral-mouse LD50 42.50 mg/kg
Defense des Vegetaux. Vol. 43(255-256), Pg. 14, 1989.
intraperitoneal-mouse LD50 136 mg/kg
Veterinary and Human Toxicology. Vol. 31, Pg. 105, 1989.
oral-dog LD50 80 mg/kg
GASTROINTESTINAL: OTHER CHANGES
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of the American Veterinary Medical Association. Vol. 193, Pg. 211, 1988.
oral-duck LD50 > 2000 mg/kg
Veterinary and Human Toxicology. Vol. 41, Pg. 344, 1999.
oral-mouse LD50 42500 ug/kg
Defense des Vegetaux. Vol. 43(255-256), Pg. 14, 1989.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | nutrient supplements |
| Recommendation for (+)-vitamin D3 usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for (+)-vitamin D3 flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Scientific Opinion on the safety and efficacy of vitamin D3 (cholecalciferol) as a feed additive for pigs, piglets, bovines, ovines, calves, equines, chickens for fattening, turkeys, other poultry, fish and other animal species or categories, based on a dossier submitted by Fermenta Biotech Ltd
View page or View pdf
|
Safety of vitamin D3 addition to feedingstuffs for fish
View page or View pdf
|
Safety for the environment of vitamin D3 for salmonids
View page or View pdf
|
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):67-97-0 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5280795 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol |
| Chemidplus:0000067970 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:VS2900000 for cas# 67-97-0 |
References:
| | (1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 67-97-0 |
| Pubchem (cid): | 5280795 |
| Pubchem (sid): | 134971039 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cholecalciferol | | 9,10-seco(5Z,7E)-5,7,10(19)- | cholestatrien-3-ol | | | colecalciferol | | | cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-(1,5-dimethylhexyl)octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)- | | | cyclohexanol, 3-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3Z)- | | (1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5- | dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yliden}ethyliden]-4-methylidencyclohexanol | | (1S,3Z)-3-[(2E)-2-{(1R,3aS,7aR)-1-[(1R)-1,5- | dimethylhexyl]-7a-methyloctahydro-4H-inden-4-ylidene}ethylidene]-4-methylidenecyclohexanol | | | granuvit D3 | | (1S,3Z)-4- | methylene-3-[(2E)-2-{(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-2-heptanyl]octahydro-4H-inden-4-ylidene}ethylidene]cyclohexanol | | | provitina | | (5Z,7E)-(3S)-9,10- | seco-5,7,10(19)-cholestatrien-3-ol | | (3S,5Z,7E)-9,10- | secocholesta-5,7,10-trien-3-ol | | (3b,5Z,7E)-9,10- | secocholesta-5,7,10(19)-trien-3-ol | | (3S,5Z,7E)-9,10- | secocholesta-5,7,10(19)-trien-3-ol | | (3β,5Z,7E)-9,10- | secocholesta-5,7,10(19)-trien-3-ol | | (5Z,7E)-(3S)-9,10- | secocholesta-5,7,10(19)-trien-3-ol |
Articles:
| PubMed:Vitamin D3 fortification, quantification, and long-term stability in Cheddar and low-fat cheeses. |
| J-Stage:The Vitamin D3 1alpha-Hydroxylase Gene and Its Regulation by Active Vitamin D3 |
| PubMed:Supplemental vitamin D3 concentration and biological type of steers. II. Tenderness, quality, and residues of beef. |
| PubMed:Improving pork quality by feeding supranutritional concentrations of vitamin D3. |
| PubMed:[Chemical and sensory characterization of cakes enriched with dietary fiber and micronutrient for the elderly]. |
| PubMed:Effect of vitamin D status improvement with 25-hydroxycholecalciferol on skeletal muscle growth characteristics and satellite cell activity in broiler chickens. |
| PubMed:The 3 Epimer of 25-Hydroxycholecalciferol Is Present in the Circulation of the Majority of Adults in a Nationally Representative Sample and Has Endogenous Origins. |
| PubMed:Vitamin d fortified bread improves pain and physical function domains of quality of life in nursing home residents. |
| PubMed:Low vitamin D status throughout life results in an inflammatory prone status but does not alter bone mineral or strength in healthy 3-month-old CD-1 male mice. |
| PubMed:Diet, sun, and lifestyle as determinants of vitamin D status. |
| PubMed:Simultaneous quantification of vitamin D3, 25-hydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in human serum by LC-MS/MS. |
| PubMed:Vitamin D Supplementation Efficacy: Sleeve Gastrectomy Versus Gastric Bypass Surgery. |
| PubMed:Altered vitamin D status in liver tissue and blood plasma from Greenland sledge dogs (Canis familiaris) dietary exposed to organohalogen contaminated minke whale (Balaenoptera acuterostrata) blubber. |
| PubMed:Dietary calcium does not interact with vitamin D3 in terms of determining the response and catabolism of serum 25-hydroxyvitamin D during winter in older adults. |
| PubMed:Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. |
| PubMed:Triennial Growth Symposium--Novel roles for vitamin D in animal immunity and health. |
| PubMed:Simultaneous determination of vitamins D2 and D3 by electrospray ionization LC/MS/MS in infant formula and adult nutritionals: First Action 2012.11. |
| PubMed:Free-range farming: a natural alternative to produce vitamin D-enriched eggs. |
| PubMed:Vitamin D3 and beta-carotene deficiency is associated with risk of esophageal squamous cell carcinoma - results of a case-control study in China. |
| PubMed:Are vitamins A and D important in the development of food allergy and how are they best measured? |
| PubMed:Seasonal variation of vitamin and sterol content of chironomidae larvae. |
| PubMed:Sunlight and Vitamin D: A global perspective for health. |
| PubMed:High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. |
| PubMed:Amphiphilic chitosan derivative-based core-shell micelles: synthesis, characterisation and properties for sustained release of Vitamin D3. |
| PubMed:25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study. |
| PubMed:Hormonal relationships to bone mass in elderly Spanish men as influenced by dietary calcium and vitamin D. |
| PubMed:Vitamin B12 as a potential compliance marker for fish intake. |
| PubMed:Stability of vitamin D in foodstuffs during cooking. |
| PubMed:Quadruple parallel mass spectrometry for analysis of vitamin D and triacylglycerols in a dietary supplement. |
| PubMed:Vitamin d status and supplementation in elite irish athletes. |
| PubMed:Increased stability and protease resistance of the β-lactoglobulin/vitamin D3 complex. |
| PubMed:Vitamin D fortification of eggs for human health. |
| PubMed:Vitamin D deficiency in reproductive age Mongolian women: a cross sectional study. |
| PubMed:Modulation of vitamin d status and dietary calcium affects bone mineral density and mineral metabolism in göttingen minipigs. |
| PubMed:The atopic dermatitis-like symptoms induced by MC903 were alleviated in JNK1 knockout mice. |
| PubMed:Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial. |
| PubMed:Tissue specific heterogeneity in effector immune cell response. |
| PubMed:Vitamin D intake and lung cancer risk in the Women's Health Initiative. |
| PubMed:25-(OH)VitD3, as a risk indicator in diagnosis of adenocarcinoma. |
| PubMed:1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. |
| PubMed:Enhanced transcription of pancreatic peptide YY by 1α-hydroxyvitamin D3 administration in streptozotocin-induced diabetic mice. |
| PubMed:UVB exposure of farm animals: study on a food-based strategy to bridge the gap between current vitamin D intakes and dietary targets. |
| PubMed:The osteogenic potential of the marine-derived multi-mineral formula aquamin is enhanced by the presence of vitamin D. |
| PubMed:Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis. |
| PubMed:Comparison of the effects of canola oil versus sunflower oil on the biochemical markers of bone metabolism in osteoporosis. |
| PubMed:Does vitamin D3 supplementation improve glucose homeostasis in overweight or obese women? A double-blind, randomized, placebo-controlled clinical trial. |
| PubMed:Correlation between serum vitamin d level and the severity of atopic dermatitis associated with food sensitization. |
| PubMed:Quantification of vitamin D and 25-hydroxyvitamin D in soft tissues by liquid chromatography-tandem mass spectrometry. |
| PubMed:Cholecalciferol. |
| PubMed:Low iron status as a factor of increased bone resorption and effects of an iron and vitamin D-fortified skimmed milk on bone remodelling in young Spanish women. |
| PubMed:Carboxymethyl chitosan-soy protein complex nanoparticles for the encapsulation and controlled release of vitamin D₃. |
| PubMed:Factors significantly increasing or inhibiting early stages of malignant melanoma (M.M.) and non-invasive evaluation of new treatment by ingestion and external application of optimal doses of the most effective anti-M.M. substances: haritaki, cilantro, vitamin D3, nori, EPA with DHA, & application of special (+) solar energy stored paper, which reduced the M.M. active area & asbestos rapidly. |
| PubMed:Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. |
| PubMed:Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats. |
| PubMed:Altered plasma concentrations of trace elements in ulcerative colitis patients before and after surgery. |
| PubMed:The influence of latitude on the concentration of vitamin D3 and 25-hydroxy-vitamin D3 in Australian red meat. |
| PubMed:Vitamin d status and supplementation in elite irish athletes. |
| PubMed:Efficacy of vitamin D loading doses on serum 25-hydroxy vitamin D levels in school going adolescents: an open label non-randomized prospective trial. |
| PubMed:The steady-state serum concentration of genistein aglycone is affected by formulation: a bioequivalence study of bone products. |
| PubMed:Quantification of vitamin D3 and its hydroxylated metabolites in waxy leaf nightshade (Solanum glaucophyllum Desf.), tomato (Solanum lycopersicum L.) and bell pepper (Capsicum annuum L.). |
| PubMed:Vitamin D3: an ever green molecule. |
| PubMed:Amelioration of chronic fluoride toxicity by calcium and fluoride-free water in rats. |
| PubMed:Quantification of vitamin D3 in feed, food, and pharmaceuticals using high-performance liquid chromatography/tandem mass spectrometry. |
| PubMed:Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds. |
| PubMed:Supplementation, optimal status, and analytical determination of vitamin D: where are we standing in 2012? |
| PubMed:Method for simultaneous analysis of eight analogues of vitamin D using liquid chromatography tandem mass spectrometry. |
| PubMed:Fortification of cheese with vitamin D3 using dairy protein emulsions as delivery systems. |
| PubMed:The effect of vitamin D on calcium absorption in older women. |
| PubMed:Application of ultra-high-performance liquid chromatography/tandem mass spectrometry for the measurement of vitamin D in infant formula and adult/pediatric nutritional formula: First Action 2011.11. |
| PubMed:Fortified malted milk drinks containing low-dose ergocalciferol and cholecalciferol do not differ in their capacity to raise serum 25-hydroxyvitamin D concentrations in healthy men and women not exposed to UV-B. |
| PubMed:Relative effectiveness of oral 25-hydroxyvitamin D3 and vitamin D3 in raising wintertime serum 25-hydroxyvitamin D in older adults. |
| PubMed:Implications for 25-hydroxyvitamin D testing of public health policies about the benefits and risks of vitamin D fortification and supplementation. |
| PubMed:Vitamin D supplementation modulates blood and tissue zinc, liver glutathione and blood biochemical parameters in diabetic rats on a zinc-deficient diet. |
| PubMed:Pet food recalls and pet food contaminants in small animals. |
| PubMed:Vitamin D3 and the risk of CVD in overweight and obese women: a randomised controlled trial. |
| PubMed:Effects of vitamin D3 on the expression of growth-related oncogene-α in THP-1 cells and human primary monocytes. |
| PubMed:Effect of Lactobacillus sporogenes on oral isoflavones bioavailability: single dose pharmacokinetic study in menopausal women. |
| PubMed:Development of zein nanoparticles coated with carboxymethyl chitosan for encapsulation and controlled release of vitamin D3. |
| PubMed:Probiotic bacterial strains differentially modulate macrophage cytokine production in a strain-dependent and cell subset-specific manner. |
| PubMed:Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. |
| PubMed:Urbanization of black South African women may increase risk of low bone mass due to low vitamin D status, low calcium intake, and high bone turnover. |
| PubMed:Solar UV doses of young Americans and vitamin D3 production. |
| PubMed:Release of lipophilic molecules during in vitro digestion of soy protein-stabilized emulsions. |
| PubMed:Ligustrazine improves atherosclerosis in rat via attenuation of oxidative stress. |
| PubMed:Nutritional approach for inhibiting bone resorption in institutionalized elderly women with vitamin D insufficiency and high prevalence of fracture. |
| PubMed:Application of ultra-performance liquid chromatography/tandem mass spectrometry for the measurement of vitamin D in foods and nutritional supplements. |
| PubMed:Validation study of the VitaKit A test kit for the determination of vitamin A in fluid milk (2% fat) for routine quality control. Performance Tested Method 061001. |
| PubMed:Bioavailability and efficacy of vitamin D2 from UV-irradiated yeast in growing, vitamin D-deficient rats. |
| PubMed:Vitamin D3 quantification in a cod liver oil-based supplement. |
| PubMed:Preparation and characterization of nanoparticles based on hydrophobic alginate derivative as carriers for sustained release of vitamin D3. |
| PubMed:[Vitamin D--an old vitamin in a new perspective]. |
| PubMed:Effects of phytase and 25-hydroxyvitamin D3 inclusions on the performance, mineral balance and bone parameters of grower-finisher pigs fed low-phosphorus diets. |
| PubMed:Effects of vitamin D3 on expression of tumor necrosis factor-alpha and chemokines by monocytes. |
| PubMed:Long-term cereal-based nutritional supplementation improved the total spine bone mineral density amongst Sri Lankan preschool children: a randomized controlled study. |
| PubMed:[The effect of simvastatin on the expression of high mobility group box-1 protein in atherosclerotic rats]. |
| PubMed:Vitamin D-vitamin K interaction: effect of vitamin D supplementation on serum percentage undercarboxylated osteocalcin, a sensitive measure of vitamin K status, in Danish girls. |
| PubMed:Milk fortified with the current adequate intake for vitamin D (5 microg) increases serum 25-hydroxyvitamin D compared to control milk but is not sufficient to prevent a seasonal decline in young women. |
| PubMed:Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults? |
| PubMed:The effects of a 30-month dietary intervention on bone mineral density: the Postmenopausal Health Study. |
| PubMed:Vitamin D supplementation suppresses age-induced bone turnover in older women who are vitamin D deficient. |
| PubMed:Vitamin D3 distribution and status in the body. |
| PubMed:Survey of minerals and fat-soluble vitamins in captive black and white ruffed lemurs (Varecia variegata). |
| PubMed:Vitamin D and the parenteral nutrition patient. |
| PubMed:Oxidation of endobiotics mediated by xenobiotic-metabolizing forms of human cytochrome. |
| PubMed:Simultaneous determination of cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) in foods by selected reaction monitoring. |
| PubMed:Supplementing dairy steers and organically managed dairy cows with synthetic vitamin D3 is unnecessary at pasture during exposure to summer sunlight. |
| PubMed:Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants. |
| PubMed:Vitamin D: a rapid review. |
| PubMed:Estimated benefit of increased vitamin D status in reducing the economic burden of disease in western Europe. |
| PubMed:Comparison of analysis of vitamin D3 in foods using ultraviolet and mass spectrometric detection. |
| PubMed:Foxp3 expressing regulatory T-cells in allergic disease. |
| PubMed:Vitamin D status of Year 3 children and supplementation through schools with fortified milk. |
| PubMed:Effects of dietary vitamin D3 administration on innate immune parameters of seabream (Sparus aurata L.). |
| PubMed:Vitamin D: a rapid review. |
| PubMed:Effects of a multi-component exercise program and calcium-vitamin-D3-fortified milk on bone mineral density in older men: a randomised controlled trial. |
| PubMed:Vitamin D status assessed by a validated HPLC method: within and between variation in subjects supplemented with vitamin D3. |
| PubMed:Synergistic antileukemic activity of carnosic acid-rich rosemary extract and the 19-nor Gemini vitamin D analogue in a mouse model of systemic acute myeloid leukemia. |
| PubMed:Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. |
| PubMed:Vitamin D3 fortification, quantification, and long-term stability in Cheddar and low-fat cheeses. |
| PubMed:The bioavailability of vitamin D from fortified cheeses and supplements is equivalent in adults. |
| PubMed:The effect of breeder age and egg storage time on phosphorus utilization by broiler progeny fed a phosphorus deficiency diet with 1alpha-OH vitamin D3. |
| PubMed:[Interaction of calcium drug and vitamin D3 with some medicines used in coronary heart disease therapy]. |
| PubMed:Vitamin D in foods: development of the US Department of Agriculture database. |
| PubMed:Vitamin D deficiency: a worldwide problem with health consequences. |
| PubMed:Development of a green chromatographic method for determination of fat-soluble vitamins in food and pharmaceutical supplement. |
| PubMed:Effects of vitamin D fortified milk on vitamin D status in Mongolian school age children. |
| PubMed:The skeletal benefits of calcium- and vitamin D3-fortified milk are sustained in older men after withdrawal of supplementation: an 18-mo follow-up study. |
| PubMed:Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study. |
| PubMed:Use of ultrasonography to detect calcifications in cattle and sheep fed Trisetum flavescens silage. |
| PubMed:Convenient analysis of vitamin D in cheese and other food matrixes by liquid chromatography/mass spectrometry. |
| PubMed:Changes in biochemical indexes of bone metabolism and bone mineral density after a 12-mo dietary intervention program: the Postmenopausal Health Study. |
| PubMed:Interactions between iron(III)-hydroxide polymaltose complex and commonly used medications / laboratory studies in rats. |
| PubMed:Combined calcium and vitamin D supplementation is not superior to calcium supplementation alone in improving disturbed bone metabolism in patients with congestive heart failure. |
| PubMed:Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1. |
| PubMed:25-hydroxyvitamin D3 affects vitamin D status similar to vitamin D3 in pigs--but the meat produced has a lower content of vitamin D. |
| PubMed:Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, Part 2. |
| PubMed:Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. |
| PubMed:Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. |
| PubMed:Factors that influence the cutaneous synthesis and dietary sources of vitamin D. |
| PubMed:Risk assessment for vitamin D. |
| PubMed:Skeletal site-dependent response of bone mineral density and quantitative ultrasound parameters following a 12-month dietary intervention using dairy products fortified with calcium and vitamin D: the Postmenopausal Health Study. |
| PubMed:[Vitamin D3--a prodrug of different D3-hormones]. |
| PubMed:Chronic contamination with 137Cesium affects Vitamin D3 metabolism in rats. |
| PubMed:Long-term effects of calcium-vitamin-D3-fortified milk on bone geometry and strength in older men. |
| PubMed:[The photobiology of vitamin D--a topic of renewed focus]. |
| PubMed:Vitamin D physiology. |
| PubMed:Barriers to optimizing vitamin D3 intake for the elderly. |
| PubMed:Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards. |
| PubMed:Calcium- and vitamin D3-fortified milk reduces bone loss at clinically relevant skeletal sites in older men: a 2-year randomized controlled trial. |
| PubMed:1,25-dihydroxyvitamin d3 enhances systemic and mucosal immune responses to inactivated poliovirus vaccine in mice. |
| PubMed:Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia. |
| PubMed:Effects of calcium, dairy product, and vitamin D supplementation on bone mass accrual and body composition in 10-12-y-old girls: a 2-y randomized trial. |
| PubMed:Interactions of vitamin D3 with bovine beta-lactoglobulin A and beta-casein. |
| PubMed:Bioavailability of vitamin D from fortified process cheese and effects on vitamin D status in the elderly. |
| PubMed:UV doses worldwide. |
| PubMed:Short communication: serum and tissue concentrations of vitamin D metabolites in beef heifers after buccal dosing of 25-hydroxyvitamin D3. |
| PubMed:Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1. |
| PubMed:[Vitamin D supplementation for chronic kidney disease according to the guideline issued by DOQI]. |
| PubMed:Effect of supplemental vitamin D3 concentration on concentrations of calcium, phosphorus, and magnesium relative to protein in subcellular components of the longissimus and the distribution of calcium within longissimus muscle of beef steers. |
| PubMed:Supplemental vitamin D3 concentration and biological type of steers. II. Tenderness, quality, and residues of beef. |
| PubMed:Supplemental vitamin D3 concentration and biological type of beef steers. I. Feedlot performance and carcass traits. |
| PubMed:Effects of biological type of beef steers on vitamin D, calcium, and phosphorus status. |
| PubMed:Cestrum diurnum leaf as a source of 1,25(OH)2 Vitamin D3 improves egg shell thickness. |
| PubMed:Effects of aluminum on phosphate metabolism in rats: a possible interaction with vitamin D3 renal production. |
| PubMed:Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1. |
| PubMed:Effect of vitamin D2- and D3-enriched diets on egg vitamin D content, production, and bird condition during an entire production period. |
| PubMed:Vitamin D deficiency rickets due to soybean milk. |
| PubMed:Simultaneous quantification of vitamins A, D3 and E in fortified infant formulae by liquid chromatography-mass spectrometry. |
| PubMed:Reproductive abnormalities, teratogenicity, and developmental problems in American kestrels (Falco sparverius) exposed to polychlorinated biphenyls. |
| PubMed:[Chemical and sensory characterization of cakes enriched with dietary fiber and micronutrient for the elderly]. |
| PubMed:[C-cells of the thyroid gland in experimental osteoporosis]. |
| PubMed:Determination of cholecalciferol (vitamin D3) in selected foods by liquid chromatography: NMKL collaborative study. |
| PubMed:Estimation and fortification of vitamin D3 in pasteurized process cheese. |
| PubMed:Vitamin D3 metabolism in dogs. |
| PubMed:Short-term feeding of vitamin D3 improves color but does not change tenderness of pork-loin chops. |
| PubMed:The combination of 1alpha,25(OH2)-vitamin D3, calcium and acetylsalicylic acid affects azoxymethane-induced aberrant crypt foci and colorectal tumours in rats. |
| PubMed:Effect of vitamin D3 supplementation level on the postmortem tenderization of beef from steers. |
| PubMed:Nutritional rickets and osteomalacia in school children and adolescents. |
| PubMed:Effects of supplemental vitamin D3 on feed intake, carcass characteristics, tenderness, and muscle properties of beef steers. |
| PubMed:Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. |
| PubMed:[Determination of vitamin D3 in health-care foods fortified with calcium by reversed-phase high performance liquid chromatography]. |
| PubMed:Effect of 1alpha-hydroxyvitamin D3 and egg-shell calcium on bone metabolism in ovariectomized osteoporotic model rats. |
| PubMed:Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. |
| PubMed:[Vitamin D3 poisoning--case report]. |
| PubMed:Turkey osteomyelitis complex. |
| PubMed:Nutrition and skeletal problems in poultry. |
| PubMed:Vitamin D in an ecological context. |
| PubMed:Influences of long-term administration of 24R, 25-dihydroxyvitamin D3, a vitamin D3 derivative, in rats. |
| PubMed:Pharmacokinetic study of 45Ca administered intravenously following intramuscular injection of vitamin D3 or 25-hydroxyvitamin D3 in early weaned lambs. |
| PubMed:Altered expression of bone sialoproteins in vitamin D-deficient rBSP2.7Luc transgenic mice. |
| PubMed:Low-molecular-weight hormonal factors that affect head formation in Hydra. |
| PubMed:Vitamin D3 requirement of young chicks receiving diets varying in calcium and available phosphorus. |
| PubMed:Activity of various hydroxylated vitamin D3 analogs for improving phosphorus utilisation in chicks receiving diets adequate in vitamin D3. |
| PubMed:Vitamin D3 enhances mood in healthy subjects during winter. |
| PubMed:Binding of vitamin D and cholesterol to beta-lactoglobulin. |
| PubMed:Calcium and vitamin D3 supplementation prevents bone loss in the spine secondary to low-dose corticosteroids in patients with rheumatoid arthritis. A randomized, double-blind, placebo-controlled trial. |
| PubMed:Efficacy of supplemental 1 alpha-hydroxycholecalciferol and microbial phytase for young pigs fed phosphorus- or amino acid-deficient corn-soybean meal diets. |
| PubMed:[Hypocalcemic tetany in 'alternative' soy milk nutrition in the first months of life]. |
| PubMed:[Nutritional and biochemical studies on vitamin D and its active derivatives]. |
| PubMed:Experimental studies on bovine Hyena disease induced by administration of excessive vitamin AD3E premix, vitamin A, or vitamin D3. |
| PubMed:Low calcium diet in hypercalciuric calcium nephrolithiasis: first do no harm. |
| PubMed:Prevention of secondary hyperparathyroidism and hip fracture in elderly women with calcium and vitamin D3 supplements. |
| PubMed:Safety and efficacy of increasing wintertime vitamin D and calcium intake by milk fortification. |
| PubMed:Vitamin D toxicosis in cats: natural outbreak and experimental study. |
| PubMed:Safety of 25-hydroxycholecalciferol as a source of cholecalciferol in poultry rations. |
| PubMed:Expression of calcitonin receptors on human myeloid leukemia cells. |
| PubMed:Vitamin D3 intoxication in naked mole-rats (Heterocephalus glaber) leads to hypercalcaemia and increased calcium deposition in teeth with evidence of abnormal skin calcification. |
| PubMed:[Vitamin D and pubertal maturation. Value and tolerance of vitamin D supplementation during the winter season]. |
| PubMed:Vitamin D metabolism in the Damara mole-rat is altered by exposure to sunlight yet mineral metabolism is unaffected. |
| PubMed:Clinical nutrition of exotic pets. |
| PubMed:Dietary boron modifies the effects of vitamin D3 nutrition on indices of energy substrate utilization and mineral metabolism in the chick. |
| PubMed:The nutritional composition of South African eggs. |
| PubMed:Analysis of milk-based infant formula. Phase IV. Iodide, linoleic acid, and vitamins D and K: U.S. Food and Drug Administration-Infant Formula Council: collaborative study. |
| PubMed:Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. |
| PubMed:Effect of dietary vitamin D3 (cholecalciferol) on colon carcinogenesis induced by 1,2-dimethylhydrazine in male Fischer 344 rats. |
| PubMed:Calcium and inorganic phosphorus metabolism in naked mole rats Heterocephalus glaber is only indirectly affected by cholecalciferol. |
| PubMed:Effects of massive small bowel resection on metabolism of bile acids and vitamin D3 and gastrin release in dogs. |
| PubMed:[Vitamin D prophylaxis in childhood]. |
| PubMed:[Determination of vitamin D in food using high performance liquid chromatography (HPLC). Results of collaborating studies of the working group "Vitamin Analysis" according to section 35 of the German Food Act]. |
| PubMed:Different forms of alkaline phosphatase in adult rat femur. Effect of a vitamin D3-deficient diet and of a sorbitol-enriched diet. |
| PubMed:The vitamin D content of fortified milk and infant formula. |
| PubMed:Hypervitaminosis D associated with drinking milk. |
| PubMed:Severe hypophosphatemia in a patient with anorexia nervosa during oral feeding. |
| PubMed:Effect of oral cholecalciferol supplementation at physiological and supraphysiological doses in naturally vitamin D3-deficient subterranean damara mole rats (Cryptomys damarensis). |
| PubMed:Contribution of the biliary pathway to the homeostasis of vitamin D3 and of 1,25-dihydroxyvitamin D3. |
| PubMed:Effects of vitamin or mineral deficiency on the morphology of medullary bone in laying hens. |
| PubMed:Is vitamin D3 essential for mineral metabolism in the Damara mole-rat (Cryptomys damarensis)? |
| PubMed:Vitamin D absorption, plasma concentration and urinary excretion of 25-hydroxyvitamin D in nephrotic syndrome. |
| PubMed:Absorption of a pharmacological dose of vitamin D3 from two different lipid vehicles in man: comparison of peanut oil and a medium chain triglyceride. |
| PubMed:The effect of 1 alpha,25-dihydroxyvitamin D3 added to a layer diet containing adequate amounts of vitamin D3 on the performance of layers. |
| PubMed:[The effect of the trichothecene mycotoxin deoxynivalenol (vomitoxin) on calcium homeostasis, vitamin D metabolism and receptors in rats]. |
| PubMed:Effects of a dietary magnesium deficiency and excess vitamin D3 on swine coronary arteries. |
| PubMed:Influence of zinc and calcium deficiency on the concentrations of calcitonin, parathyroid hormone, and 25-hydroxy-vitamin D3 in rat serum. |
| PubMed:Vitamin D status and concentrations of serum vitamin D metabolites and osteocalcin in elderly patients with femoral neck fracture: a follow-up study. |
| PubMed:Determination of vitamin D3 in margarines, oils and other supplemented food products using HPLC. |
| PubMed:High-dose vitamin D therapy: indications, benefits and hazards. |
| PubMed:Vitamin D and pancreatic islet function. I. Time course for changes in insulin secretion and content during vitamin D deprivation and repletion. |
| PubMed:[The effect of hypervitaminosis D3 on the bones of the chicken. 2. Electron microscopic studies]. |
| PubMed:[The effect of hypervitaminosis D3 on the bones of the hen. 1. Light microscopy studies]. |
| PubMed:Dietary magnesium effect on swine coronary atherosclerosis induced by hypervitaminosis D. |
| PubMed:High performance liquid chromatographic determination of cholecalciferol (vitamin D3) in food--a comparison with a bioassay method. |
| PubMed:Mandibular growth and histologic changes in condylar cartilage of rats intoxicated with vitamin D3 or 1,25(OH)2D3 and pair-fed (undernourished) rats. |
| PubMed:Absorption, deposition and distribution of dietary aluminium in immature rats: effects of dietary vitamin D3 and food-borne chelating agent. |
| PubMed:Effects of dietary vitamin D3 on concentrations of vitamin D and its metabolites in blood plasma and milk of dairy cows. |
| PubMed:Plasma 1.25-dihydroxyvitamin D concentrations in preterm infants. |
| PubMed:Angiotoxicity in swine of a moderate excess of dietary vitamin D3. |
| PubMed:Effects in sheep of high dietary levels of vitamin D3 as measured by circulating concentrations of some vitamin D metabolites and skeletal examination. |
| PubMed:[Serum 25-hydroxyvitamin D3 levels in 3- and 6-month-old Warsaw infants receiving daily prophylactically vitamin D3 "Polfa"]. |
| PubMed:Effects of supplementary vitamin D3 on egg production of two strains of Japanese quail and growth of their progeny. |
| PubMed:Liquid chromatographic determination of vitamins D2 and D3 in fortified milk and infant formulas. |
| PubMed:Liquid chromatographic determination of vitamin D in milk and infant formula. |
| PubMed:Effect of various vitamin D analogs on plasma calcium and phosphorus and intestinal calcium absorption in fed and unfed American eels, Anguilla rostrata. |
| PubMed:1,25-Dihydroxyvitamin D3 normalizes maternal food consumption and pup growth in rats. |
| PubMed:Vitamin D, 25-hydroxy-vitamin D and 1,25-dihydroxy-vitamin D in cow's milk, infant formulas and breast milk during different stages of lactation. |
| PubMed:Skeletal growth in experimental uremia. |
| PubMed:Effect of fat retention on the rachitogenic effect of rye fed to broiler chicks. |
| PubMed:[Effect of microclimate, supplementary mineral elements Cu, Mn and Zn and vitamins A + D3 on selected blood indicators and piglet rearing]. |
| PubMed:[Experimental cadmium poisoning]. |
| PubMed:High-performance liquid chromatographic determination of vitamin D3 in foods with particular reference to eggs. |
| PubMed:Analysis of fat-soluble vitamins. XXVII. High performance liquid chromatographic and gas-liquid chromatographic determination of vitamin D in fortified milk and milk powder: collaborative study. |
| PubMed:Analysis of fat-soluble vitamins. XXVI. High performance liquid chromatographic determination of vitamin D in fortified milk and milk powder. |
| PubMed:Growth and bone mineralisation as affected by dietary calcium, phytic acid and vitamin D. |
| PubMed:[Comparative antirachitic activity of vitamins D2 and D3 in the body of chicks]. |
| PubMed:Tibial dyschondroplasia in broilers: comparison to dietary additives and strains. |
| PubMed:Plasma 25-hydroxyvitamin D concentrations in preterm infants receiving oral vitamin D supplements. |
| PubMed:Simplified assay of vitamin D2 in fortified dried milk by using two steps of high-performance liquid chromatography. |
| PubMed:1,25-Dihydroxyvitamin D3 stimulated increase of 7,8-didehydrocholesterol levels in rat skin. |
| PubMed:[Effect of 1 alpha-hydroxycholecalciferol and of a varying phosphorus requirement on mineral metabolism in chronic renal insufficiency]. |
| PubMed:A family with massive acute vitamin D intoxication. |
| PubMed:25-hydroxyvitamin D in plasma of cattle. |
| PubMed:Nutrition imbalance and angiotoxins as dietary risk factors in coronary heart disease. |
| PubMed:[Studies on the vitamin requirement and vitamin supply in fattening turkeys. 2. Checking the vitamin supplements to state-approved mixed animal feed for fattening turkeys]. |
| PubMed:[Biological method of quantitating vitamin D in different preparations and diets]. |
| PubMed:High pressure liquid chromatographic determination of vitamin D3 in livestock feed supplements. |
| PubMed:Skeletal changes and growth in experimental uremia. |
| PubMed:[Determination of vitamin D3 in premixes and mixed feeds]. |
| PubMed:Inhibition of biological activity of cholecalciferol (vitamin D3) by o,p'-DDT or p,p'-DDT in Rachitic cockerel. |
| PubMed:[Effect of thyrocalcitonin on the assimilation of calcium in food ingested with vitamin D3 or sodium acid carbonate]. |
| PubMed:[Histology of the epiphyseal cartilage of rachitic rats as a function of the calcium & phosphorus content of food & vitamin D3 intake]. |
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derivative of 7-dehydroxycholesterol formed by ultraviolet rays breaking of the c9-c10 bond. it differs from ergocalciferol in having a single bond between c22 and c23 and lacking a methyl group at c24. Constit. of fish-liver oil, esp. tuna oil. Antirachitic vitamin with approx. the same potency as vitamin D2 in humans
Cholecalciferol (vitamin D3) is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A.
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3D/inchi