EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

fd&c red no. 3 (c.i. 45430 (Na))
erythrosine

Supplier Sponsors

CAS Number: 16423-68-0Picture of molecule3D/inchi
Other(deleted CASRN):111634-12-9
ECHA EINECS - REACH Pre-Reg:240-474-8
FDA UNII: 8TL7LH93FM
Nikkaji Web:J77.650E
Beilstein Number:1443945
MDL:MFCD00144257
Molecular Weight:881.87717856
Formula:C20 H8 I4 Na2 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:coloring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Erythrosine View - review
JECFA Food Additive: Erythrosine
GSFA Codex: Erythrosine (127)
DG SANTE Food Additives:erythrosine
FDA Mainterm (SATF):16423-68-0 ; FD&C RED NO. 3
FDA Regulation:
FDA PART 74 -- LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION
Subpart B--Drugs
Sec. 74.1303 FD&C Red No. 3.


FDA PART 74 -- LISTING OF COLOR ADDITIVES SUBJECT TO CERTIFICATION
Subpart A--Foods
Sec. 74.303 FD&C Red No. 3.


FDA PART 81 -- GENERAL SPECIFICATIONS AND GENERAL RESTRICTIONS FOR PROVISIONAL COLOR ADDITIVES FOR USE IN FOODS, DRUGS,
AND COSMETICS
Sec. 81.10 Termination of provisional listings of color additives
 
Physical Properties:
Appearance:red powder (est)
Assay: 87.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.290
Soluble in:
 alcohol
 water
 water, 2.29 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: cosmetic colorants
 
Suppliers:
BOC Sciences
For experimental / research use only.
Erythrosine > 95%
Odor: characteristic
Use: Erythrosine B is a derivative of fluorone and is used as a cherry-pink synthetic colour additives used on food products.
EMD Millipore
For experimental / research use only.
Erythrosine B (C.I. 45430)
Flavorchem
FD&C Red No. 3
Glentham Life Sciences
Erythrosin B sodium salt (C.I. 45430), certified
Glentham Life Sciences
Erythrosin B sodium salt (C.I. 45430)
Kishi Kasei
Red No.3
Prinova
Color-Red #3
Rung International
Erythrosine
Rung International
FD&C Red No.3
Rung International
Lake Erythrosine
Santa Cruz Biotechnology
For experimental / research use only.
Erythrosin extra bluish
Sigma-Aldrich
For experimental / research use only.
Erythrosin B
analytical standard
TCI AMERICA
For experimental / research use only.
Erythrosine B >95.0%(E)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1840 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Scientia Pharmaceutica. Vol. 47, Pg. 39, 1979.

oral-mouse LD50 1264 mg/kg
Eastern Pharmacist. Vol. 24, Pg. 125, 1981.

intravenous-mouse LD50 370 mg/kg
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 9, Pg. 127, 1952.

intravenous-rabbit LD50 200 mg/kg
FAO Nutrition Meetings Report Series. Vol. 38B, Pg. 50, 1966.

intraperitoneal-rat LD50 300 mg/kg
FAO Nutrition Meetings Report Series. Vol. 38B, Pg. 50, 1966.

intravenous-rat LD50 200 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Scientia Pharmaceutica. Vol. 47, Pg. 39, 1979.

unreported-rat LD50 1895 mg/kg
Nara Igaku Zasshi. Journal of the Nara Medical Association. Vol. 30, Pg. 179, 1979.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
coloring agents
Recommendation for fd&c red no. 3 (c.i. 45430 (Na)) usage levels up to:
 not for fragrance use.
 
Recommendation for fd&c red no. 3 (c.i. 45430 (Na)) flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of Erythrosine (E 127) as a food additive
View page or View pdf

Scientific Opinion on the safety and efficacy of erythrosine in feed for cats and dogs, ornamental fish and reptiles
View page or View pdf

Update of the Scientific Opinion on the safety and efficacy of erythrosine in feed for cats, dogs, reptiles and ornamental fish
View page or View pdf

Safety of erythrosine for ornamental fish
View page or View pdf

EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):16423-68-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :27872
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
disodium;2-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoate
Chemidplus:0016423680
RTECS:LM5950000 for cas# 16423-68-0
 
References:
 disodium;2-(2,4,5,7-tetraiodo-3-oxido-6-oxoxanthen-9-yl)benzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:16423-68-0
Pubchem (cid):27872
Pubchem (sid):135017864
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB29702
FooDB:FDB000892
Export Tariff Code:2932.99.7000
FDA Color Additive Status ListView
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 cosmetic colorants
 hair dyeing agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acid red 51 (c.i. 45430 (Na))
 benzoic acid, 2-(6-hydroxy-2,4,5,7-tetraiodo-3-oxo-3H-xanthen-9-yl)-, sodium salt (1:2)
 c.i. 45430 (Na)
 ci 45430 (Na)
3',6-dihydroxy-2',4',5',7'-tetraiodospiro(isobenzofuran-1(3H),9'(9H)xanthen)-one disodium salt
3',6'-dihydroxy-2',4',5',7'-tetraiodospiro[isobenzofuran-1(3H),9'[9H]xanthen]-3-one disodium salt
 disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxo-3H-xanthen-9-yl)benzoate
 disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxoxanthen-9-yl) benzoate (c.i. 45430 (Na))
 disodium 2-(2,4,5,7-tetraiodo-6-oxido-3-oxoxanthen-9-yl)benzoate
 disodium 2',4',5',7'-tetraiodofluorescein
 erythrosin B (c.i. 45430 (Na))
 erythrosin B sodium salt
 erythrosine
 fd&c red 3
 fd&c red no. 3 (c.i. 45430 (Na))
 fluorescein, 2',4',5',7'-tetraiodo-, disodium salt
 food dye red 3
 food red 14
 food red no. 3
2-(6-hydroxy-2,4,5,7-tetraiodo-3-oxoxanthen-9-yl)benzoic acid, sodium salt, sodium salt
 red dye no. 3
2',4',5',7'-tetraiodofluorescein, disodium salt
2',4',5',7'-tetraiodofluoroescein disodium salt
 
 
Notes:
a tetraiodofluorescein used as a red coloring in some foods (cherries, fish), as a disclosure of dental plaque, and as a stain of some cell types. it has structural similarity to thyroxine. Dye used in food and feed additives. Prohibited in U.S.A. and Norway [DFC] Erythrosine, also known as Red No. 3, is a cherry-pink synthetic fluorone food coloring. It is the disodium salt of 2,4,5,7-tetraiodofluorescein. Erythrosine is commonly used in sweets such as some candies and popsicles, and even more widely used in cake-decorating gels. While commonly used in many countries of the world, erythrosine is less commonly used in the United States because Allura Red AC (Red #40) is generally used instead. However, Allura Red AC is banned in many European countries solely because it is an azo dye, despite scientific consensus of Red 40 having fewer known health risks. [Wikipedia]
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