peg/ppg-98/67 copolymer, 9003-11-6

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CODE113162 CODE113162
Product(s):
9003-11-6 Poloxamer Liquid 95%

Penta International Corporation

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CODE113162 CODE113162
Product(s):
16-59805 POLOXAMER 407 FCC
16-59800 POLOXAMER 407 NF

Name:	2-methyloxirane; oxirane (98;67)
CAS Number:	9003-11-6	3D/inchi
Other(deleted CASRN):	106717-66-2
FDA UNII:	Search
Formula:	(C3 H6 O.C2 H4 O)x-
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:emulsifiers and foaming agents

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
	FDA/DG SANTE Petitions, Reviews, Notices:
FCN 1020	Ethylene glycol-propylene glycol polymer View - notice
FCN 1293	Oxirane, methyl-, polymer with oxirane View - notice
FDA Mainterm (SATF):	9003-11-6 ; ETHYLENE OXIDE/PROPYLENE OXIDE COPOLYMER
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart I--Multipurpose Additives Sec. 172.808 Copolymer condensates of ethylene oxide and propylene oxide. FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart D--Specific Usage Additives Sec. 173.340 Defoaming agents. FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS Subpart B--Substances for Use Only as Components of Paper and Paperboard Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard. FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS Subpart B--Substances for Use Only as Components of Paper and Paperboard Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard. FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Sec. 177.1210 Closures with sealing gaskets for food containers. FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact Sec. 177.1680 Polyurethane resins. FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS Subpart B--Substances Utilized To Control the Growth of Microorganisms Sec. 178.1010 Sanitizing solutions. FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS Subpart D--Certain Adjuvants and Production Aids Sec. 178.3570 Lubricants with incidental food contact.

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	275.31 °C. @ 760.00 mm Hg (est)
Vapor Pressure:	0.001000 mmHg @ 25.00 °C. (est)
Flash Point:	249.00 °F. TCC ( 120.30 °C. ) (est)
logP (o/w):	-1.293 (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	surfactants surfactant - emulsifying

Suppliers:

BOC Sciences

For experimental / research use only.

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 175 mg/kg Microvascular Research. Vol. 8, Pg. 320, 1974. oral-mouse LD50 3000 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. oral-mouse LD50 > 15000 mg/kg Drug and Chemical Toxicology. Vol. 1, Pg. 89, 1977/1978. oral-mouse LD50 45000 mg/kg Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970. intraperitoneal-mouse LDLo 5000 mg/kg Therapie. Vol. 14, Pg. 721, 1959. intravenous-mouse LDLo 6000 mg/kg Therapie. Vol. 14, Pg. 721, 1959. oral-mouse LDLo 15000 mg/kg Therapie. Vol. 14, Pg. 721, 1959. oral-rabbit LD50 35000 mg/kg Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970. oral-rat LD50 5700 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. intraperitoneal-rat LDLo 10000 mg/kg Therapie. Vol. 14, Pg. 721, 1959. oral-rat LDLo 16000 mg/kg Toxicology and Applied Pharmacology. Vol. 16, Pg. 675, 1970.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-rat LC50 320 mg/m3/4H LIVER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES National Technical Information Service. Vol. OTS0539401

Safety in Use Information:

Category:
emulsifiers and foaming agents
Recommendation for peg/ppg-98/67 copolymer usage levels up to:
	not for fragrance use.

Recommendation for peg/ppg-98/67 copolymer flavor usage levels up to:
	not for flavor use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to an 11th list of substances for food contact materials
View page or View pdf

Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf

EPI System: View

Daily Med:search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):9003-11-6

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :24751

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:1

2-methyloxirane; oxirane (98;67)

Chemidplus:0009003116

References:

	2-methyloxirane; oxirane (98;67)
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	9003-11-6
Pubchem (cid):	24751
Pubchem (sid):	134991398

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
FDA Indirect Additives used in Food Contact Substances:	View
HMDB (The Human Metabolome Database):	Search
FDA Listing of Food Additive Status:	View
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: •trade names: bloat guard; therabloat •a block polymer of ethylene oxide and propylene oxide.

Potential Blenders and core components note

None Found

Potential Uses:

	emollients
	emulsifying agents
	humectants
	solvents
	surfactants

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	methyl oxirane polymer with oxirane (98;67)
2-	methyloxirane; oxirane (98;67)
	oxirane, methyl, polymer with oxirane (98 mol EO, 67 mol PO average molar ratio)
	pluracare F 127
	pluronic P-123
	poloxamer 407

Articles:

PubMed:Effect of interfacial composition on uptake of curcumin-piperine mixtures in oil in water emulsions by Caco-2 cells.

PubMed:Simvastatin treatment upregulates intestinal lipid secretion pathways in a rodent model of the metabolic syndrome.

PubMed:Mechanical, rheological and release behaviors of a poloxamer 407/ poloxamer 188/carbopol 940 thermosensitive composite hydrogel.

PubMed:Antidiabetic activity and molecular docking of fructooligosaccharides produced by Aureobasidium pullulans in poloxamer-407-induced T2DM rats.

PubMed:Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility.

PubMed:Regulatory function of a malleable protein matrix as a novel fermented whey product on features defining the metabolic syndrome.

PubMed:Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats.

PubMed:Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models.

PubMed:The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins.

PubMed:Poloxamer 407-mediated changes in plasma cholesterol and triglycerides following intraperitoneal injection to rats.

Notes:

a copolymer of polyethylene and polypropylene ether glycol. it is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.

peg/ppg-98/67 copolymer oxirane, methyl, polymer with oxirane (98 mol EO, 67 mol PO average molar ratio)

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Articles:

peg/ppg-98/67 copolymer
oxirane, methyl, polymer with oxirane (98 mol EO, 67 mol PO average molar ratio)