Category:cosmetic UV absorber
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Assay: | 95.00 to 100.00
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Food Chemicals Codex Listed: | No |
Boiling Point: | 531.23 °C. @ 760.00 mm Hg (est)
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Flash Point: | 552.00 °F. TCC ( 289.10 °C. ) (est)
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logP (o/w): | 3.091 (est) |
Soluble in: |
| water, 398.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
BOC Sciences |
For experimental / research use only. |
2,2',4,4'-Tetrahydroxybenzophenone >95.0%(T)
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Charkit Chemical |
TETRAHYDROXYBENZOPHENONE, 2,2'4,4'-
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Santa Cruz Biotechnology |
For experimental / research use only. |
2,2',4,4'-Tetrahydroxybenzophenone
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Sigma-Aldrich: Aldrich |
For experimental / research use only. |
2,2',4,4'-Tetrahydroxybenzophenone 97%
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Sinoway Industrial |
For experimental / research use only. |
2,2',4,4'-Tetrahydroxy Benzophenone
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TCI AMERICA |
For experimental / research use only. |
2,2',4,4'-Tetrahydroxybenzophenone >98.0%(HPLC)
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Safety Information:
Preferred SDS: View |
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
oral-rat LD50 1220 mg/kg Journal of the American College of Toxicology. Vol. 2(5), Pg. 35, 1983.
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | cosmetic UV absorber |
Recommendation for benzophenone-2 usage levels up to: | | not for fragrance use.
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Recommendation for benzophenone-2 flavor usage levels up to: |
| not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| benzophenone, 2,2',4,4'-tetrahydroxy- | bis(2,4- | dihydroxyphenyl)methanone | | methanone, bis(2,4-dihydroxyphenyl)- | 2,2',4,4'- | tetrahydroxy-benzophenone | 2,2,4,4- | tetrahydroxybenzophenone | 2,2',4,4'- | tetrahydroxybenzophenone |
Articles:
PubMed:Cell-specific biotransformation of benzophenone-2 and bisphenol-s in zebrafish and human in vitro models used for toxicity and estrogenicity screening. |
PubMed:A simple spectrophotometric method for the determination of arsenic in industrial and environmental samples using 2,4-Dihydroxy benzophenone-2-amino thiophenol. |
PubMed:Toxicological effects of the sunscreen UV filter, benzophenone-2, on planulae and in vitro cells of the coral, Stylophora pistillata. |
PubMed:Molecular structure, vibrational spectroscopic (FT-IR, FT-Raman), UV-vis spectra, first order hyperpolarizability, NBO analysis, HOMO and LUMO analysis, thermodynamic properties of benzophenone 2,4-dicarboxylic acid by ab initio HF and density functional method. |
PubMed:In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism. |
PubMed:Synthesis, characterization, thermal and DNA-binding properties of new zinc complexes with 2-hydroxyphenones. |
PubMed:Effects of the UV filter benzophenone-2 on reproduction in fish. |
PubMed:In vitro effects of benzophenone-2 and octyl-methoxycinnamate on the production of interferon-gamma and interleukin-10 by murine splenocytes. |
PubMed:Effects of estradiol, benzophenone-2 and benzophenone-3 on the expression pattern of the estrogen receptors (ER) alpha and beta, the estrogen receptor-related receptor 1 (ERR1) and the aryl hydrocarbon receptor (AhR) in adult ovariectomized rats. |
PubMed:Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone. |
PubMed:BK/TD models for analyzing in vitro impedance data on cytotoxicity. |
PubMed:Determining ultraviolet absorbents in sunscreen products by combining direct injection with micelle collapse on-line preconcentration capillary electrophoresis. |
PubMed:A novel dispersive solid-phase extraction method using metal-organic framework MIL-101 as the adsorbent for the analysis of benzophenones in toner. |
PubMed:A multiclass method for the analysis of endocrine disrupting chemicals in human urine samples. Sample treatment by dispersive liquid-liquid microextraction. |
PubMed:Simplified matrix solid phase dispersion procedure for the determination of parabens and benzophenone-ultraviolet filters in human placental tissue samples. |
PubMed:UHPLC-MS/MS method for the determination of bisphenol A and its chlorinated derivatives, bisphenol S, parabens, and benzophenones in human urine samples. |
PubMed:A new method for the determination of benzophenone-UV filters in human serum samples by dispersive liquid-liquid microextraction with liquid chromatography-tandem mass spectrometry. |
PubMed:Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of estradiol (E2) in ovariectomized (ovx) rats. |
PubMed:Contact allergy to benzophenone-2 in toilet water. |
PubMed:Isolation, characterization and cytotoxic activity of benzophenone glucopyranosides from Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl). |
PubMed:A dose-response study on the estrogenic activity of benzophenone-2 on various endpoints in the serum, pituitary and uterus of female rats. |
PubMed:The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. |
PubMed:Pharmacokinetics and metabolism of benzophenone 2 in the rat. |
PubMed:Multi-organic endocrine disrupting activity of the UV screen benzophenone 2 (BP2) in ovariectomized adult rats after 5 days treatment. |
PubMed:Three novel lanthanide metal-organic frameworks (Ln-MOFs) constructed by unsymmetrical aromatic dicarboxylatic tectonics: synthesis, crystal structures and luminescent properties. |
PubMed:Determination of trace levels of benzophenone-type ultra-violet filters in real matrices by bar adsorptive micro-extraction using selective sorbent phases. |
PubMed:Doubly bonded E13═P and B═E15 molecules and their reactions with H2, acetonitrile, benzophenone, and 2,3-dimethylbutadiene. |
PubMed:Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. |
PubMed:Structure elucidation and antioxidant activity of the phenolic compounds from Rhynchosia suaveolens. |
PubMed:Identification of classifiers for increase or decrease of thyroid peroxidase activity in the FTC-238/hTPO recombinant cell line. |
PubMed:Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis. |
PubMed:[Determination of ultraviolet filters in environmental aqueous samples by dispersive liquid-liquid microextraction with online derivatization-gas chromatography-mass spectrometry]. |
PubMed:Determination of benzophenones in human placental tissue samples by liquid chromatography-tandem mass spectrometry. |
PubMed:Development of a thyroperoxidase inhibition assay for high-throughput screening. |
PubMed:Up-and-down shaker-assisted ionic liquid-based dispersive liquid-liquid microextraction of benzophenone-type ultraviolet filters. |
PubMed:True photoallergy to sunscreens is rare despite popular belief. |
PubMed:One new diphenylmethane glycoside from the leaves of Psidium guajava L. |
PubMed:Determination of ultraviolet filters in water samples by vortex-assisted dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. |
PubMed:Characterisation and quantification of flavonoids in Iris germanica L. and Iris pallida Lam. resinoids from Morocco. |
PubMed:Benzophenones and xanthones from Garcinia cantleyana var. cantleyana and their inhibitory activities on human low-density lipoprotein oxidation and platelet aggregation. |
PubMed:Electrochemical oxidation of amides of type Ph2CHCONHAr. |
PubMed:Pentacobalt(II) cluster based pcu network exhibits both magnetic slow-relaxation and hysteresis behaviour. |
PubMed:Photochemistry of 2-diphenylmethoxyacetophenone. Direct detection of a long-lived enol from a Norrish Type II photoreaction. |
PubMed:Hydrazone-based ligands for micro-solid phase extraction-high performance liquid chromatographic determination of biogenic amines in orange juice. |
PubMed:Estrogenic activity of ternary UV filter mixtures in fish (Pimephales promelas) - an analysis with nonlinear isobolograms. |
PubMed:Two new benzophenone glycosides from the fruit of Psidium guajava L. |
PubMed:Comparison of in vitro and in vivo estrogenic activity of UV filters in fish. |
PubMed:Principles and methodology for identification of fragrance allergens in consumer products. |
PubMed:[Nail polish allergy. An important differential diagnosis in contact dermatitis]. |
PubMed:Simultaneous trace determination of nine organic UV-absorbing compounds (UV filters) in environmental samples. |
PubMed:Ferrimagnetic [CoII3(micro3-OH)2(RCO2)4] chains embedded in a laminar hybrid material exhibiting single-chain magnet behaviour. |
PubMed:Determination of ink photoinitiators in packaged beverages by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. |
PubMed:New phenolic principles from Hypericum sampsonii. |
PubMed:Microbial removal of wastewater organic compounds as a function of input concentration in soil columns. |
PubMed:Planar trimethylenemethane dianion chemistry of lanthanide metallocenes: synthesis, structure, density functional theory analysis, and reactivity of [(C5Me5)2Ln]2[mu-eta3:eta3-C(CH2)(3] Complexes. |
PubMed:Activity related to the carcinogenicity of plastic additives in the benzophenone group. |
PubMed:Site selectively templated and tagged xerogels for chemical sensors. |
PubMed:Radical-induced generation of small silver particles in SPEEK/PVA polymer films and solutions: UV-Vis, EPR, and FT-IR studies. |
PubMed:[Estrogenic activity of ultraviolet absorbers and the related compounds]. |
PubMed:Structure-reactivity relationships in the photoreduction of n,pi*-excited ketones and azoalkanes: the effect of reaction thermodynamics, excited-state electrophilicity, and antibonding character in the transition state. |
PubMed:Experimental study on phototoxicity and the photosensitization potential of ketoprofen, suprofen, tiaprofenic acid and benzophenone and the photocross-reactivity in guinea pigs. |
PubMed:Benzophenones of Garcinia pseudoguttifera (Clusiaceae). |
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