calcium PCA, 31377-05-6

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CODE111822 CODE111822
Product(s):
CAPGIP Calcium Pidolate

BOC Sciences

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CODE111822 CODE111822
Product(s):
31377-05-6 Calcium bis(5-oxo-L-prolinate)

Name:	calcium 5-oxopyrrolidine-2-carboxylate
CAS Number:	31377-05-6	3D/inchi
ECHA EINECS - REACH Pre-Reg:	250-602-4
FDA UNII:	7Y2LVU5EKK
Molecular Weight:	168.18542000
Formula:	C5 H6 Ca N O3 +
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:nutrient supplements

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Appearance:	white crystalline powder (est)
Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	453.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure:	0.000000 mmHg @ 25.00 °C. (est)
Flash Point:	442.00 °F. TCC ( 227.80 °C. ) (est)
logP (o/w):	-2.387 (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	humectants skin conditioning

Suppliers:

American International Chemical, LLC.

Calcium Pidolate

BOC Sciences

For experimental / research use only.

Calcium bis(5-oxo-L-prolinate)

Odor: characteristic

Use: Considered to be a second messenger involved in all of the body's biochemical reactions, calcium is the trace element which triggers the differentiation phases in epidermal cells. Calcidone, a combination of calcium and L-PCA, helps the skin to carry out or regain its role as a barrier by stimulating the cell differentiation process and activating the synthesis of total epidermal lipids, notably ceramides. Calcidone also has strong anti-MMP1 activity and consequently preserves the skin's integrity.

Solabia

Calcium Pidolate

Odor: characteristic

Use: Calcium Pidolate is a remarkably soluble salt which remains soluble across a broad spectrum of pH. In combination with Pidolic Acid, which is a composing element of the collagen matrices, it can play a double role in reinforcing the skeleton and the supporting tissue.

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
nutrient supplements
Recommendation for calcium PCA usage levels up to:
	not for fragrance use.

Recommendation for calcium PCA flavor usage levels up to:
	not for flavor use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Calcium, iron, magnesium, potassium and zinc L-pidolate as sources for calcium, iron, magnesium, potassium and zinc added for nutritional purposes to food supplements and to foods intended for particular nutritional uses
View page or View pdf

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :160204

National Institute of Allergy and Infectious Diseases:Data

calcium 5-oxopyrrolidine-2-carboxylate

Chemidplus:0031377056

References:

	calcium 5-oxopyrrolidine-2-carboxylate
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	160204
Pubchem (sid):	135114921

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
FDA Listing of Food Additive Status:	View
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	calcidone
	calcium 5-oxopyrrolidine-2-carboxylate
	calcium bis(5-oxo-L-prolinate)
	calcium bis(5-oxo-laevo-prolinate)
	calcium pidolate
	efical
2-	pyrrolidinecarboxylate, 5-oxo-, calcium salt(1:1)

Articles:

PubMed:Two flushing-like reaction cases from calcium pidolate who tolerated calcium carbonate.

PubMed:Urticaria due to calcium pidolate.

PubMed:Solubility of calcium salts and their effect on osteoporosis.

PubMed:Acute changes in serum calcium and parathyroid hormone circulating levels induced by the oral intake of five currently available calcium salts in healthy male volunteers.

PubMed:Comparison of the biochemical and hormonal acute effects of calcium salts.

PubMed:Longitudinal study of the effect of calcium pidolate on bone mass in eugonadal women.

PubMed:Effect of calcium pidolate on biochemical and hormonal parameters in involutional osteoporosis.

PubMed:[Calcium pidolate and bone metabolism parameters].

PubMed:[An analysis of calcium pidolate absorption and a comparison with that of a salt in common use, gluconate-lactate-carbonate, in postmenopausal osteoporosis].

Notes:

tradename.

calcium PCA 2-pyrrolidinecarboxylate, 5-oxo-, calcium salt(1:1)

Supplier Sponsors

Articles:

calcium PCA
2-pyrrolidinecarboxylate, 5-oxo-, calcium salt(1:1)