EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

mecobalamin
methyl-5,6-dimethylbenzimidazolylcobalamin

Supplier Sponsors

Name:carbanide;cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3
CAS Number: 13422-55-4Picture of molecule3D/inchi
Other(deleted CASRN):13870-88-7
FDA UNII: BR1SN1JS2W
MDL:MFCD00082483
Molecular Weight:1344.40502700
Formula:C63 H91 Co N13 O14 P
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -2.812 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
AIDP
Methylcobalamin B12 98% min.
American International Chemical, LLC.
Methylcobalamin 1Trituration On Mannitol
American International Chemical, LLC.
Methylcobalamin USP
BOC Sciences
For experimental / research use only.
Mecobalamin >98%
Odor: characteristic
Use: Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation.
Charkit Chemical
METHYLCOBALAMIN
George Uhe Company
Mecobalamin
Glentham Life Sciences
Methylcobalamin hydrate
Santa Cruz Biotechnology
For experimental / research use only.
Mecobalamin
Sigma-Aldrich: Sigma
For experimental / research use only.
Methylcobalamin vitamin B12 analog
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 529, 1970.

intraperitoneal-rat LD50 > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 529, 1970.

intravenous-rabbit LD50 > 75 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 529, 1970.

oral-mouse LD50 > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 529, 1970.

intraperitoneal-mouse LD50 > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 529, 1970.

intravenous-dog LD > 200 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 22, Pg. 3939, 1988.

Dermal Toxicity:
subcutaneous-rat LD50 > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 529, 1970.

subcutaneous-mouse LD50 > 5000 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 529, 1970.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for mecobalamin usage levels up to:
 not for fragrance use.
 
Recommendation for mecobalamin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

5’-deoxyadenosylcobalamin and methylcobalamin as sources for Vitamin B12 added as a nutritional substance in food supplements[1] - Scientific opinion of the Scientific Panel on Food Additives and Nutrient Sources added to food
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6436232
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
carbanide;cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3
Chemidplus:0013422554
RTECS:GG3745000 for cas# 13422-55-4
 
References:
 carbanide;cobalt(3+);[5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]1-[3-[(4Z,9Z,14Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6436232
Pubchem (sid):135030891
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C06453
HMDB (The Human Metabolome Database):HMDB02274
FooDB:FDB022939
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 algobaz
 co-methylcobalamin
 cobalt-methylcobalamin
 cobamet
 cobametin
 hitocobamin M
 methycobal
 methyl cobalamin
 methyl cobalamine
 methyl vitamin B12
 methyl-5,6-dimethylbenzimidazolylcobalamin
 methylcob(III)alamin
 methylcobal
 methylcobalamin
 methylcobaz
 vancomin
 

Articles:

PubMed:Methylcobalamin--a form of vitamin B12 identified and characterised in Chlorella vulgaris.
PubMed:Vitamin B12 content in raw and cooked beef.
PubMed:Optimization and validation of a reversed-phase high performance liquid chromatography method for the measurement of bovine liver methylmalonyl-coenzyme a mutase activity.
PubMed:Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner.
PubMed:Purification, identification, and characterization of methylcobalamin from Spirulina platensis.
PubMed:Naturally occurring cobalamins have antimalarial activity.
PubMed:Determination of vitamin B12 using the enzyme glycerol dehydrase.
PubMed:Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status.
PubMed:Homocysteine metabolism in children with Down syndrome: in vitro modulation.
PubMed:[Vitamin B 12--a rerun of a favourite].
PubMed:Genetic defects of folate and cobalamin metabolism.
PubMed:Vitamin B12 metabolism in a photosynthesizing green alga, Chlamydomonas reinhardtii.
PubMed:Conversion of hydroxo(aquo) cobalamin to sulfitocobalamin in the absence of light: a reaction of importance in the identification of the forms of vitamin B12, with possible clinical significance.
PubMed:Form of Vitamin B(12) and Its Role in a Methanol-Utilizing Bacterium Protaminobacter ruber.
PubMed:The forms of vitamin B12 in foods.
 
Notes:
The name vitamin B12 is used in two different ways. In a broad sense it refers to a group of cobalt-containing compounds known as cobalamins - cyanocobalamin (an artifact formed as a result of the use of cyanide in the purification procedures), hydroxocobalamin and the two coenzyme forms of B12, methylcobalamin (MeB12) and 5-deoxyadenosylcobalamin (adenosylcobalamin - AdoB12). In a more specific way, the term B12 is used to refer to only one of these forms, cyanocobalamin, which is the principal B12 form used for foods and in nutritional supplements. B12 cannot be made by plants or by animals, as the only type of organisms that have the enzymes required for the synthesis of B12 are bacteria and archaea. The total synthesis of B12 was reported in 1973 by Robert Burns Woodward, and remains one of the classic feats of total synthesis. Cyanocobalamin is a vitamin commonly known as vitamin B12 (or B12 for short). [HMDB]
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