|
Category:cosmetic and flavor agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow to amber powder (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 257.00 to 260.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 930.00 to 931.00 °C. @ 760.00 mm Hg
|
| Flash Point: | 582.00 °F. TCC ( 305.56 °C. )
|
| logP (o/w): | -1.212 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | store under nitrogen. |
| Storage: | refrigerate in tightly sealed containers. store under nitrogen. |
| Soluble in: |
| | water, 2125 mg/L @ 25 °C (est) |
| Insoluble in: |
| | paraffin oil |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Hesperidin 98%
|
| AuNutra® Industries |
| Hesperidin P.E
|
| BASF |
| Flavagrum™ PEG: effective reduction of under-eye puffiness
|
| BOC Sciences |
| For experimental / research use only. |
| Hesperidin
|
| Coompo |
| For experimental / research use only. |
| Hesperidin from Plants ≥96%
Odor: characteristic Use: Hesperidin has antioxidant, anti-inflammatory, hypolipidemic, vasoprotective and anticarcinogenic and cholesterol lowering actions. Hesperdin can inhibit following enzymes: phospholipase A2, lipoxygenase, HMG-CoA reductase and cyclo-oxygenase.
Hesperidin improves the health of capillaries by reducing the capillary permeability.
Hesperidin is used to reduce hay fever and other allergic conditions by inhibiting the release of histamine from mast cells. The possible anti-cancer activity of hesperidin could be explained by the inhibition of polyamine synthesis.
A study 'Hesperidin, a citrus flavonoids, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice' by Hiroshige Chiba et al (J. Nutrition, June 2003) showed that hesperidin added to the died not only lowered serum and hepatic cholesterol, but also inhibited bone loss by decreasing osteoclast number in ovariectomized mice. The molecular mechanism of the inhibitory effect of hesperidin on bone resorption is not clear. Hesperidin is believed to play a role in plant defense. It acts as an antioxidant according to in vitro studies.
Various preliminary studies reveal novel pharmaceutical properties, none of which has been confirmed as applicable to humans. Hesperidin reduced cholesterol and blood pressure in rats. In a mouse study, large doses of hesperidin decreased bone density loss. Another animal study showed protective effects against sepsis. In vitro and in laboratory research, hesperidin has anti-inflammatory effects. Hesperidin is also a potential sedative, possibly acting through opioid or adenosine receptors. Hesperidin exhibited pronounced anticancer activity against some selected human carcinoma cell lines. Some in vitro results applied only to the aglycone form. Hesperidin also showed potential to penetrate the blood–brain barrier in an in vitro model.
Hesperidin, in combination with a flavone glycoside called diosmin, is used in Europe for the treatment of venous insufficiency and hemorrhoids. Hesperidin, Rutin and other flavonoids thought to reduce capillary permeability and to have anti-inflammatory action were collectively known as vitamin P. These substances, however, are not vitamins and are no longer referred to, except in older literature, as vitamin P. |
| ExtraSynthese |
| For experimental / research use only. |
| Hesperidin (HPLC) ≥98.5%
|
| Glentham Life Sciences |
| Hesperidin
|
| Jiangyin Healthway |
| Hesperidin
|
| New functional food ingredients |
| Meafo |
| For experimental / research use only. |
| Hesperidin
|
| Nacalai USA |
| For experimental / research use only. |
| (2S)-Hesperidin
|
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Hesperidin ≥95%
|
| Sigma-Aldrich |
| For experimental / research use only. |
| Hesperidin analytical standard
|
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Hesperidin ∼80%
|
| WILD Flavors |
| Hesperidin
Flavor: taste Citrus Bioflavonoids are a family of polyphenolic compounds synthesized by plants. They are obtained from the rinds of citrus fruits and are also known as vitamin P complex. Hesperidin and Naringin are specific examples of Citrus Bioflavonoids. They are powerful antioxidants and help support heart, skin and eye health. |
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 1000 mg/kg
National Technical Information Service. Vol. AD277-689
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | cosmetic and flavor agents |
| Recommendation for hesperidin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for hesperidin flavor usage levels up to: |
| | 1000.0000 ppm in the finished product.
|
| Structure Class: | III |
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Flavouring Group Evaluation 32 (FGE.32): Flavonoids (Flavanones and dihydrochalcones) from chemical groups 25 and 30
View page or View pdf
|
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous tone pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
|
Scientific Opinion on the substantiation of a health claim related to a combination of diosmin, troxerutin and hesperidin and maintenance of normal venous-capillary permeability pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
|
| EPI System: View |
| ClinicalTrials.gov:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):520-26-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :10621 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]ox |
| Chemidplus:0000520263 |
| RTECS:MK6650000 for cas# 520-26-3 |
References:
| | (2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]ox |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 520-26-3 |
| Pubchem (cid): | 10621 |
| Pubchem (sid): | 134976842 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 7-((6-O-(6-deoxy-a-L-mannopyranosyl)-β-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)- | | (S)-7-[[6-O-(6- | deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one | | (S)-5,7- | dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-chroman-4-one | | | hesperetin 7-rhamnoglucoside | | | hesperetin-7-rutinoside | | (S)- | hesperidin | | | hesperidin, (2S)- | | | hesperidin, (S)-(-)- | | | hesperidine | | (2S)-5- | hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 6-O-(6-deoxy-a-L-mannopyranosyl)-β-D-glucopyranoside | | (S)-3',5,7- | trihydroxy-4'-methoxyflavanone | | (S)-5,7,3'- | trihydroxy-4'-methoxyflavanone |
Articles:
| PubMed:Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by d-galactose in rat brain. |
| J-Stage:Anti-Aging Effects of Hesperidin on Saccharomyces cerevisiae via Inhibition of Reactive Oxygen Species and UTH1 Gene Expression |
| PubMed:Encapsulation and micronization effectively improve orange beverage flavanones bioavailability in humans. |
| PubMed:Hesperidin Potentiates Ghrelin Signaling. |
| PubMed:Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation. |
| PubMed:Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium). |
| PubMed:Phenolic profile and in vitro antioxidant capacity of insoluble dietary fiber powders from citrus (Citrus junos Sieb. ex Tanaka) pomace as affected by ultrafine grinding. |
| PubMed:Gelidium elegans, an Edible Red Seaweed, and Hesperidin Inhibit Lipid Accumulation and Production of Reactive Oxygen Species and Reactive Nitrogen Species in 3T3-L1 and RAW264.7 Cells. |
| PubMed:Identification of phenolic compositions and the antioxidant capacity of mandarin juices and wines. |
| PubMed:Chemical guide parameters for Spanish lemon (Citrus limon (L.) Burm.) juices. |
| PubMed:Orange juice and hesperidin promote differential innate immune response in macrophages ex vivo. |
| PubMed:Soluble and insoluble phenolic compounds and antioxidant activity of immature calamondin affected by solvents and heat treatment. |
| PubMed:Hesperidin increases intestinal β,β-carotene 15-15' mono-oxygenase 1 (BCMO1) activity in Mongolian gerbils (Meriones unguiculatus) fed with β-carotene-free diet. |
| PubMed:Effects of fermentation on antioxidant properties and phytochemical composition of soy germ. |
| PubMed:Effects of hesperidin loaded poly(lactic-co-glycolic acid) scaffolds on growth behavior of costal cartilage cells in vitro and in vivo. |
| PubMed:Sonochemical effects on 14 flavonoids common in citrus: relation to stability. |
| PubMed:[Substrate specificity of Cryptococcus albidus and Eupenicillium erubescens alpha-L-rhamnosidases]. |
| PubMed:In-vitro evaluation of bioactive compounds, anti-oxidant, lipid peroxidation and lipoxygenase inhibitory potential of Citrus karna L. peel extract. |
| PubMed:Rikkunshito ameliorates bleomycin-induced acute lung injury in a ghrelin-independent manner. |
| PubMed:Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin. |
| PubMed:Hydrolysis of flavanone glycosides by β-glucosidase from Pyrococcus furiosus and its application to the production of flavanone aglycones from citrus extracts. |
| PubMed:Phenolic compositions and antioxidant capacities of Chinese wild mandarin (Citrus reticulata Blanco) fruits. |
| PubMed:Citrus flavanones enhance carotenoid uptake by intestinal Caco-2 cells. |
| PubMed:Comparison of phenolic compounds of orange juice processed by pulsed electric fields (PEF) and conventional thermal pasteurisation. |
| PubMed:Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells. |
| PubMed:Ethanol extract of the Prunus mume fruits stimulates glucose uptake by regulating PPAR-γ in C2C12 myotubes and ameliorates glucose intolerance and fat accumulation in mice fed a high-fat diet. |
| PubMed:Simultaneous determination of six bioactive flavonoids in Citri Reticulatae Pericarpium by rapid resolution liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry. |
| PubMed:Application of TLC method with video scanning in estimation of daily dietary intake of specific flavonoids--preliminary studies. |
| PubMed:Effects of yam peel extract against carbon tetrachloride-induced hepatotoxicity in rats. |
| PubMed:Hesperidin metabolite hesperetin-7-O-glucuronide, but not hesperetin-3'-O-glucuronide, exerts hypotensive, vasodilatory, and anti-inflammatory activities. |
| PubMed:Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. |
| PubMed:Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra-Performance Liquid Chromatography. |
| PubMed:Boehmeria nivea attenuates LPS-induced inflammatory markers by inhibiting p38 and JNK phosphorylations in RAW264.7 macrophages. |
| PubMed:Hesperidin associated with continuous and interval swimming improved biochemical and oxidative biomarkers in rats. |
| PubMed:The gene expression of the hypothalamic feeding-regulating peptides in cisplatin-induced anorexic rats. |
| PubMed:Individual and combined effects of genistein and hesperidin supplementation on meat quality in meat-type broiler chickens. |
| PubMed:Enzymatic modification enhances the protective activity of citrus flavonoids against alcohol-induced liver disease. |
| PubMed:Bioavailability of dietary (poly)phenols: a study with ileostomists to discriminate between absorption in small and large intestine. |
| PubMed:Functions of monocyte chemotactic protein-3 in transgenic mice fed a high-fat, high-cholesterol diet. |
| PubMed:Quantification of hesperidin in citrus-based foods using a fungal diglycosidase. |
| PubMed:Effects of dietary hesperidin supplementation on lamb performance and meat characteristics. |
| PubMed:A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract. |
| PubMed:Prunin- and hesperetin glucoside-alkyl (C4-C18) esters interaction with Jurkat cells plasma membrane: consequences on membrane physical properties and antioxidant capacity. |
| PubMed:Phytochemical profile and antioxidant activity of physiological drop of citrus fruits. |
| PubMed:Characterization of an α-L-Rhamnosidase from Streptomyces avermitilis. |
| PubMed:A comparison study on the binding of hesperetin and luteolin to bovine serum albumin by spectroscopy. |
| PubMed:Assessment of phytochemical content in human milk during different stages of lactation. |
| PubMed:Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity. |
| PubMed:Antioxidant activity and effective compounds of immature calamondin peel. |
| PubMed:Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions. |
| PubMed:Identification of flavonoids with trypsin inhibitory activity extracted from orange peel and green tea leaves. |
| PubMed:Stability of bioactive polyphenols from honey during different extraction methods. |
| PubMed:Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori. |
| PubMed:Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. |
| PubMed:Evaluation of matrix effect in determination of some bioflavonoids in food samples by LC-MS/MS method. |
| PubMed:Inhibitory effects of Citrus flavonoids on starch digestion and antihyperglycemic effects in HepG2 cells. |
| PubMed:Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques. |
| PubMed:Purification of naringin and neohesperidin from Huyou (Citrus changshanensis) fruit and their effects on glucose consumption in human HepG2 cells. |
| PubMed:Tyrosinase inhibitory components of immature calamondin peel. |
| PubMed:The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways. |
| PubMed:[A novel C27-steroidal glycoside sulfate from Liriope graminifolia]. |
| PubMed:The composition of volatile aroma components, flavanones, and polymethoxylated flavones in Shiikuwasha (Citrus depressa Hayata) peels of different cultivation lines. |
| PubMed:Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells. |
| PubMed:Phytonutrient intake by adults in the United States in relation to fruit and vegetable consumption. |
| PubMed:Bioevaluation of human serum albumin-hesperidin bioconjugate: insight into protein vector function and conformation. |
| PubMed:Enzymatic modification of chitosan with quercetin and its application as antioxidant edible films. |
| PubMed:Citrus flavanones: what is their role in cardiovascular protection? |
| PubMed:Inhibition of quorum sensing (QS) in Yersinia enterocolitica by an orange extract rich in glycosylated flavanones. |
| PubMed:Study on the interference of rat feed to pharmacokinetics of flavonoids. |
| PubMed:Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression. |
| PubMed:Protective effect of hesperidin, a citrus flavanoglycone, against γ-radiation-induced tissue damage in Sprague-Dawley rats. |
| PubMed:Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy. |
| PubMed:Screening of the antioxidant properties and polyphenol composition of aromatised green tea infusions. |
| PubMed:Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites. |
| PubMed:Melanogenesis of murine melanoma cells induced by hesperetin, a Citrus hydrolysate-derived flavonoid. |
| PubMed:Polyphenolic content and comparative antioxidant capacity of flavoured black teas. |
| PubMed:Citrus juice extraction systems: effect on chemical composition and antioxidant activity of clementine juice. |
| PubMed:Neuroprotective effects of citrus flavonoids. |
| PubMed:Antioxidant and anti-inflammatory activities of aqueous extracts of Schizonepeta tenuifolia Briq. |
| PubMed:Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study. |
| PubMed:Changes on phenolic and carotenoid composition of high intensity pulsed electric field and thermally treated fruit juice-soymilk beverages during refrigerated storage. |
| PubMed:Features of the complex of food additive hesperidin to hemoglobin. |
| PubMed:Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach. |
| PubMed:Effect of citrus polyphenol- and curcumin-supplemented diet on inflammatory state in obese cats. |
| PubMed:Beneficial effect of hesperetin on cadmium induced oxidative stress in rats: an in vivo and in vitro study. |
| PubMed:Anti-platelet effects of yuzu extract and its component. |
| PubMed:Kaempferol inhibits enterovirus 71 replication and internal ribosome entry site (IRES) activity through FUBP and HNRP proteins. |
| PubMed:Controlling for sugar and ascorbic acid, a mixture of flavonoids matching navel oranges significantly increases human postprandial serum antioxidant capacity. |
| PubMed:α-Rhamnosyl-β-glucosidase-catalyzed reactions for analysis and biotransformations of plant-based foods. |
| PubMed:Antioxidant capacities and total phenolic contents increase with gamma irradiation in two types of Malaysian honey. |
| PubMed:Characterization of two distinct glycosyl hydrolase family 78 alpha-L-rhamnosidases from Pediococcus acidilactici. |
| PubMed:Simultaneous determination of flavanones, hydroxycinnamic acids and alkaloids in citrus fruits by HPLC-DAD-ESI/MS. |
| PubMed:Electrooxidation of flavonoids at platinum electrode studied by cyclic voltammetry. |
| PubMed:Chemical composition and biological activity of Citrus jambhiri Lush. |
| PubMed:Role of citrus juices and distinctive components in the modulation of degenerative processes: genotoxicity, antigenotoxicity, cytotoxicity, and longevity in Drosophila. |
| PubMed:Influence of rootstock and cultivar on bioactive compounds in citrus peels. |
| PubMed:Effect of cation exchange resin treatment and addition on sugar as anti-caking agent on retention of nutritional and sensory quality of lemon juice powder during storage. |
| PubMed:Naringinases: occurrence, characteristics, and applications. |
| PubMed:Role of the cultivar in choosing Clementine fruits with a high level of health-promoting compounds. |
| PubMed:[Flavonoids--bioactive compounds in fruits juice]. |
| PubMed:Effect of hesperetin against oxidative stress via ER- and TrkA-mediated actions in PC12 cells. |
| PubMed:The citrus flavonoid hesperidin induces p53 and inhibits NF-κB activation in order to trigger apoptosis in NALM-6 cells: involvement of PPARγ-dependent mechanism. |
| PubMed:Hesperidin partially restores impaired immune and nutritional function in irradiated mice. |
| PubMed:Analysis of bioactive compounds in seven citrus cultivars. |
| PubMed:Evaluation of the antioxidant properties of fruit and flavoured black teas. |
| PubMed:Purification and characterization of a novel alkaline α-L-rhamnosidase produced by Acrostalagmus luteo albus. |
| PubMed:Potentiation of ghrelin signaling attenuates cancer anorexia-cachexia and prolongs survival. |
| PubMed:Effects of thermal and high hydrostatic pressure processing and storage on the content of polyphenols and some quality attributes of fruit smoothies. |
| PubMed:Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFκB, p38 and caspase-3. |
| PubMed:Study of the polyphenolic composition and antioxidant activity of new sherry vinegar-derived products by maceration with fruits. |
| PubMed:Inactivation of nuclear factor-κB by citrus flavanone hesperidin contributes to apoptosis and chemo-sensitizing effect in Ramos cells. |
| PubMed:Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription. |
| PubMed:On the inhibitor effects of bergamot juice flavonoids binding to the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) enzyme. |
| PubMed:Synergistic and antagonistic interactions of phenolic compounds found in navel oranges. |
| PubMed:Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. |
| PubMed:Introduction of distillate rosemary leaves into the diet of the Murciano-Granadina goat: transfer of polyphenolic compounds to goats' milk and the plasma of suckling goat kids. |
| PubMed:Comparison of hesperetin and its metabolites for cholesterol-lowering and antioxidative efficacy in hypercholesterolemic hamsters. |
| PubMed:Effects of hesperetin on the production of inflammatory mediators in IL-1beta treated human synovial cells. |
| PubMed:Stereoselective conjugation, transport and bioactivity of s- and R-hesperetin enantiomers in vitro. |
| PubMed:Concentration and solubility of flavanones in orange beverages affect their bioavailability in humans. |
| PubMed:Polymethoxylated flavones, flavanone glycosides, carotenoids, and antioxidants in different cultivation types of tangerines ( Citrus reticulata Blanco cv. Sainampueng) from Northern Thailand. |
| PubMed:Effect of added citrus fibre and spice essential oils on quality characteristics and shelf-life of mortadella. |
| PubMed:Electrocatalytic behaviour of citric acid at a cobalt phthalocyanine-modified screen-printed carbon electrode and its application in pharmaceutical and food analysis. |
| PubMed:Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction. |
| PubMed:Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells. |
| PubMed:Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet. |
| PubMed:The effect of co-administered flavonoids on the metabolism of hesperetin and the disposition of its metabolites in Caco-2 cell monolayers. |
| PubMed:Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. |
| PubMed:Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from alpha-rhamnosidase-treated orange juice in human subjects. |
| PubMed:Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata. |
| PubMed:Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation. |
| PubMed:Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells. |
| PubMed:Simultaneous determination of phenolic acids and flavonoids in Lycium barbarum Linnaeus by HPLC-DAD-ESI-MS. |
| PubMed:Major phytochemical composition of 3 native Korean citrus varieties and bioactive activity on V79-4 cells induced by oxidative stress. |
| PubMed:Simultaneous determination of five bioactive flavonoids in pericarpium Citri reticulatae from china by high-performance liquid chromatography with dual wavelength detection. |
| PubMed:Efficacy of the potential chemopreventive agent, hesperetin (citrus flavanone), on 1,2-dimethylhydrazine induced colon carcinogenesis. |
| PubMed:The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. |
| PubMed:Physiological and biochemical characterization of the two alpha-L-rhamnosidases of Lactobacillus plantarum NCC245. |
| PubMed:Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. |
| PubMed:[Study on the interaction of hesperidin or icariin with lysozyme by fluorescence spectroscopy]. |
| PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. |
| PubMed:Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract. |
| PubMed:Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt. |
| PubMed:Naringenin and hesperetin induce growth arrest, apoptosis, and cytoplasmic fat deposit in human preadipocytes. |
| PubMed:Absorption, metabolism and excretion of flavanones from single portions of orange fruit and juice and effects of anthropometric variables and contraceptive pill use on flavanone excretion. |
| PubMed:Chemical characterization of Citrus sinensis grafted on C. limonia and the effect of some isolated compounds on the growth of Xylella fastidiosa. |
| PubMed:Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. |
| PubMed:Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. |
| PubMed:Phenolic compounds and antioxidant activity of extracts from ultrasonic treatment of Satsuma Mandarin (Citrus unshiu Marc.) peels. |
| PubMed:In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts. |
| PubMed:Development of a potential reference material for evaluating antioxidant activity. |
| PubMed:Enhanced bioavailability of verapamil after oral administration with hesperidin in rats. |
| PubMed:Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. |
| PubMed:Hesperidin in orange juice reduces the absorption of celiprolol in rats. |
| PubMed:Effects of alpha-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans. |
| PubMed:Interactions affecting the bioavailability of dietary polyphenols in vivo. |
| PubMed:Minerals, phenolic compounds, and antioxidant capacity of citrus peel extract by hot water. |
| PubMed:Distinct effects of naringenin and hesperetin on nitric oxide production from endothelial cells. |
| PubMed:Transepithelial transport of flavanone in intestinal Caco-2 cell monolayers. |
| PubMed:Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells. |
| PubMed:Antimicrobial activity of flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a byproduct of the essential oil industry. |
| PubMed:Transepithelial transport of hesperetin and hesperidin in intestinal Caco-2 cell monolayers. |
| PubMed:Chemical screening of olive biophenol extracts by hyphenated liquid chromatography. |
| PubMed:Ultrasound-assisted extraction of hesperidin from Penggan (Citrus reticulata) peel. |
| PubMed:Effects of flavonoid on calcium content in femoral tissue culture and parathyroid hormone-stimulated osteoclastogenesis in bone marrow culture in vitro. |
| PubMed:Esterase inhibition by grapefruit juice flavonoids leading to a new drug interaction. |
| PubMed:Thermal degradation of antioxidant micronutrients in citrus juice: kinetics and newly formed compounds. |
| PubMed:Flavanone plasma pharmacokinetics from blood orange juice in human subjects. |
| PubMed:Attenuation of monocyte adhesion and oxidised LDL uptake in luteolin-treated human endothelial cells exposed to oxidised LDL. |
| PubMed:Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity. |
| PubMed:A new method for fabrication of an integrated indium tin oxide electrode on electrophoresis microchips with amperometric detection and its application for determination of synephrine and hesperidin in pericarpium citri reticulatae. |
| PubMed:Studies on the cytological and biochemical effects of valerian in somatic and germ cells of Swiss albino mice. |
| PubMed:Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling. |
| PubMed:Use of NIRS for quantification of mangiferin and hesperidin contents of dried green honeybush (Cyclopia genistoides) plant material. |
| PubMed:Citrus flavonoids in fruit and traditional Chinese medicinal food ingredients in China. |
| PubMed:Activity and mRNA levels of enzymes involved in hepatic fatty acid oxidation in mice fed citrus flavonoids. |
| PubMed:Evaluation of the anti-allergic activity of Citrus unshiu using rat basophilic leukemia RBL-2H3 cells as well as basophils of patients with seasonal allergic rhinitis to pollen. |
| PubMed:Effect of citrus flavonoids on lipid metabolism and glucose-regulating enzyme mRNA levels in type-2 diabetic mice. |
| PubMed:Bound sugars in hepatic glycoproteins from male rats during dietary citrus bioflavonoid and/or ascorbic acid supplementation. |
| PubMed:Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC. |
| PubMed:Additive or synergetic effects of phenolic compounds on human low density lipoprotein oxidation. |
| PubMed:Efficiency of foam fractionation for the enrichment of nonpolar compounds from aqueous extracts of plant materials. |
| PubMed:Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. |
| PubMed:Varietal and interspecific influence on micronutrient contents in citrus from the Mediterranean area. |
| PubMed:Degradation of neohesperidin dihydrochalcone by human intestinal bacteria. |
| PubMed:Passive cutaneous anaphylaxis-inhibitory activity of flavanones from Citrus unshiu and Poncirus trifoliata. |
| PubMed:The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids. |
| PubMed:Identification and quantification of the conjugated metabolites derived from orally administered hesperidin in rat plasma. |
| PubMed:The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. |
| PubMed:Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. |
| PubMed:Separation of flavanone-7-O-glycoside diastereomers and analysis in citrus juices by multidimensional liquid chromatography coupled with mass spectrometry. |
| PubMed:Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway. |
| PubMed:Embryotoxicity and teratogenicity study with neohesperidin dihydrochalcone in rats. |
| PubMed:Flavonoids promote cell migration in nontumorigenic colon epithelial cells differing in Apc genotype: implications of matrix metalloproteinase activity. |
| PubMed:Evaluation of hesperetin 7-O-lauryl ether as lipid-lowering agent in high-cholesterol-fed rats. |
| PubMed:Double-strand break of giant DNA: protection by glucosyl-hesperidin as evidenced through direct observation on individual DNA molecules. |
| PubMed:Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia. |
| PubMed:Adsorption of flavonoids on resins: cyanidin 3-glucoside. |
| PubMed:Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (cv. Valencia Late) fruits against Phytophthora citrophthora. |
| PubMed:[Pharmacological action of hesperidin]. |
| PubMed:Effect of the rootstock and interstock grafted in lemon tree (Citrus limon (L.) Burm.) on the flavonoid content of lemon juice. |
| PubMed:Adsorption of flavonoids on resins: hesperidin. |
| PubMed:Inhibitory activity of flavonoids from Prunus davidiana and other flavonoids on total ROS and hydroxyl radical generation. |
| PubMed:Pro-oxidative properties of flavonoids in human lymphocytes. |
| PubMed:Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and alpha 2-adrenergic receptors in Xenopus laevis melanophores. |
| PubMed:Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. |
| PubMed:Flavonoids detection by HPLC-DAD-MS-MS in lemon juices from Sicilian cultivars. |
| PubMed:Influence of industrial processing on orange juice flavanone solubility and transformation to chalcones under gastrointestinal conditions. |
| PubMed:Effects of long-term administration of hesperidin and glucosyl hesperidin to spontaneously hypertensive rats. |
| PubMed:Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. |
| PubMed:Recovery of anthocyanins from pulp wash of pigmented oranges by concentration on resins. |
| PubMed:Plasma concentrations of the flavonoids hesperetin, naringenin and quercetin in human subjects following their habitual diets, and diets high or low in fruit and vegetables. |
| PubMed:Inhibition of colonic aberrant crypt formation by the dietary flavonoids (+)-catechin and hesperidin. |
| PubMed:Isolation of antioxidant compounds from orange juice by using countercurrent supercritical fluid extraction (CC-SFE). |
| PubMed:Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and polymethoxylated flavones in citrus peel molasses. |
| PubMed:[Determination of neohesperidin dihydrochalcone in foods]. |
| PubMed:In vitro availability of flavonoids and other phenolics in orange juice. |
| PubMed:Improved water solubility of neohesperidin dihydrochalcone in sweetener blends. |
| PubMed:PROP (6-n-Propylthiouracil) tasting and sensory responses to caffeine,sucrose, neohesperidin dihydrochalcone and chocolate. |
| PubMed:Inhibitors of 15-lipoxygenase from orange peel. |
| PubMed:Flavonoids in pigmented orange juice and second-pressure extracts. |
| PubMed:In vitro inhibitory effect of some flavonoids on rotavirus infectivity. |
| PubMed:Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats. |
| PubMed:Preparation of a monoclonal antibody to N(epsilon)-(Hexanonyl)lysine: application to the evaluation of protective effects of flavonoid supplementation against exercise-induced oxidative stress in rat skeletal muscle. |
| PubMed:Isolation of luteolin 7-O-rutinoside and esculetin with potential antioxidant activity from the aerial parts of Artemisia montana. |
| PubMed:Waste water from citrus processing as a source of hesperidin by concentration on styrene-divinylbenzene resin. |
| PubMed:Effect of gamma-irradiation on phenolic compounds and phenylalanine ammonia-lyase activity during storage in relation to peel injury from peel of Citrus clementina hort. Ex. tanaka. |
| PubMed:Transglycosylation of neohesperidin dihydrochalcone by Bacillus stearothermophilus maltogenic amylase. |
| PubMed:Double functionality of sweeteners: a case of study. |
| PubMed:Recovery of hesperidin from orange peel by concentration of extracts on styrene-divinylbenzene resin. |
| PubMed:HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices. |
| PubMed:Phenolics: blocking agents for heterocyclic amine-induced carcinogenesis. |
| PubMed:Inhibition of neoplastic transformation and bioavailability of dietary flavonoid agents. |
| PubMed:Validated high-performance liquid chromatographic method for quantitation of neohesperidine dihydrochalcone in foodstuffs. |
| PubMed:Flavanone absorption after naringin, hesperidin, and citrus administration. |
| PubMed:Rhamnogalacturonan alpha-L-rhamnopyranohydrolase. A novel enzyme specific for the terminal nonreducing rhamnosyl unit in rhamnogalacturonan regions of pectin. |
| PubMed:Subchronic toxicity study of methyl hesperidin in mice. |
| PubMed:Solid-phase extraction and HPLC determination of 4-vinyl guaiacol and its precursor, ferulic acid, in orange juice. |
| PubMed:Antihyperlipidemic effect of flavonoids from Prunus davidiana. |
| PubMed:Carcinogenicity study of methyl hesperidin in B6C3F1 mice. |
| PubMed:Subchronic (13-week) oral toxicity of neohesperidin dihydrochalcone in rats. |
| PubMed:Liquid chromatographic determination of naringin and neohesperidin as a detector of grapefruit juice in orange juice. |
| PubMed:An investigation of the effect of hesperidin complex and lemon bioflavonoid complex on growth and development of thoroughbred horses. |
| PubMed:A high-performance liquid chromatographic method for the quantitation of hesperidin in orange juice. |
| PubMed:The influence of an extract of orange peel on the growth and ascorbic acid metabolism of young guinea-pigs. |
| PubMed:Specificity of the vanillin test for flavanols. |
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