EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

lawsone
1,4-naphthalenedione, 2-hydroxy-

Supplier Sponsors

CAS Number: 83-72-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-496-3
FDA UNII: TLH4A6LV1W
Nikkaji Web:J4.642F
Beilstein Number:1565260
MDL:MFCD00001678
XlogP3-AA:0.90 (est)
Molecular Weight:174.15542000
Formula:C10 H6 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:hair dyeing agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 194.00 °C. @ 760.00 mm Hg
Boiling Point: 352.40 °C. @ 760.00 mm Hg (est)
Flash Point: 358.00 °F. TCC ( 181.10 °C. ) (est)
logP (o/w): 1.380
Soluble in:
 water, 3895 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-Hydroxy-1,4-naphoquinone 98%
ExtraSynthese
For experimental / research use only.
Lawsone (HPLC) ≥95%
Santa Cruz Biotechnology
For experimental / research use only.
2-Hydroxy-1,4-naphthoquinone ≥98%
Sigma-Aldrich
For experimental / research use only.
2-Hydroxy-1,4-naphthoquinone 97%
TCI AMERICA
For experimental / research use only.
2-Hydroxy-1,4-naphthoquinone >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 100 mg/kg
Journal of Medicinal Chemistry. Vol. 26, Pg. 570, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
hair dyeing agents
Recommendation for lawsone usage levels up to:
 not for fragrance use.
 
Recommendation for lawsone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):83-72-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6755
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-hydroxynaphthalene-1,2-dione
Chemidplus:0000083727
EPA/NOAA CAMEO:hazardous materials
RTECS:QL8200000 for cas# 83-72-7
 
References:
 4-hydroxynaphthalene-1,2-dione
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6755
Pubchem (sid):134971696
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10368
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2914.50.3000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 hair dyeing agents
 
Occurrence (nature, food, other):note
 henna
Search Trop Picture
 
Synonyms:
 c.i. 75480
 C.I. natural orange 6
2-hydroxy-1,4-naphthalenedione
2-hydroxy-1,4-naphthoquinone
2-hydroxy-1,4-naphthoquinone
2-hydroxynaphthalene-1,2-dione
2-hydroxynaphthoquinone
 lawson
 mehendi
1,4-naphthalenedione, 2-hydroxy-
1,4-naphthoquinone, 2-hydroxy-
 natural orange 6 (c.i. 75480)
 

Articles:

PubMed:Antifungal activity of the Algerian Lawsonia inermis (henna).
PubMed:Rapid determination of para-phenylenediamine by gas chromatography-mass spectrometry with selected ion monitoring in henna-containing cosmetic products.
PubMed:Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
PubMed:Absorption of lawsone through human skin.
PubMed:Determination of some organochlorine compounds in herbal colouring agent henna (Lawsonia inermis) and in tea (Thea sinensis).
PubMed:Selective growth-inhibiting effects of compounds identified in Tabebuia impetiginosa inner bark on human intestinal bacteria.
PubMed:[Cosmetic colorants. Toxicology and regulation].
PubMed:Toxicity and human health risk of hair dyes.
PubMed:Differential toxicity of juglone (5-hydroxy-1,4-naphthoquinone) and related naphthoquinones to saturniid moths.
PubMed:An investigation of dye reduction by food-borne bacteria.
 
Notes:
from leaves of lawsonia inermis l. topical sunscreening agent; powdered leaves of lawsonia inermis(lythraceae) used as brown hair dye.
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