EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

alpha-tocophenol
vitaplex E

Supplier Sponsors

CAS Number: 59-02-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-412-2
FDA UNII: N9PR3490H9
Nikkaji Web:J529.413D
Beilstein Number:4712525
MDL:MFCD00072045
XlogP3-AA:10.70 (est)
Molecular Weight:430.71590000
Formula:C29 H50 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants and preservatives for fragrance and flavor
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1890 alpha-Tocopherols View - review
GRN 307 Palm oil-derived tocols with tocotrienols and a-tocopherol as the principal components View - notice PDF
EU SANCO Tocopherol-rich extract View - review
EU SANCO Alpha-tocopherol View - review
GRN 781 Alpha-tocopherol (fruit and vegetable derived) View - notice PDF
JECFA Food Additive: dl-alpha-Tocopherol

Tocopherol Concentrate, mixed

d-alpha-Tocopherol Concentrate
GSFA Codex: dl-alpha-Tocopherol (307c)

Tocopherol concentrate, mixed (307b)

d-alpha-Tocopherol (307a)
DG SANTE Food Additives:alpha-tocophenol
DG SANTE Food Contact Materials:alpha-tocophenol
 
Physical Properties:
Appearance:pale yellow to red clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 2.00 to 3.00 °C. @ 760.00 mm Hg
Boiling Point: 482.00 to 485.00 °C. @ 760.00 mm Hg
Flash Point: 410.00 °F. TCC ( 210.00 °C. )
logP (o/w): 10.962 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage:refrigerate in tightly sealed containers.
Soluble in:
 alcohol
 water, 2.978e-007 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
fragrance
skin conditioning
 
Suppliers:
ADM
NOVATOL 1490
ADM
NOVATOL 5-67 NON GMO
ADM
NOVATOL 5-67
Flavor: characteristic
NOVATOL 5-67 is a clear, amber color, viscous oil having a slight characteristic vegetable oil aroma and a mild taste. NOVATOL 5-67 may oxidize upon exposure to air and light, resulting in gradual darkening. Nitrogen blanketing and protection from light, from heat, from transition metals and from alkalis are recommended. NOVATOL 5-67 is a concentrated form of natural source d-alpha-tocopherol derived from edible vegetable oils. Research indicates that the human body prefers the natural source Vitamin E, such as NOVATOL 5-67, over the synthetic forms. Moreover, based on the Food and Nutrition Board Expert Panel report on Vitamin E, d-alpha-tocopherol has twice the activity of synthetic forms, which means that natural Vitamin E is 100% more effective. (Dietary Reference Intakes For Vitamin C, Vitamin E, Selenium, and Carotenoids. 2000. Vitamin E , National Academy Press, Washington, D.C.,186-283.) NOVATOL 5-67 is an essential nutrient and dietary supplement widely used in softgel capsules and liquid preparations.
ADM
NOVATOL 5-87
Flavor: characteristic
NOVATOL 5-87 is a clear, amber color, viscous oil having a slight characteristic vegetable oil aroma and a mild taste. NOVATOL 5-87 may oxidize upon exposure to air and light, resulting in gradual darkening. Nitrogen blanketing and protection from light, from heat, from transition metals and from alkalis are recommended. NOVATOL 5-87 is a concentrated form of natural source d-alpha-tocopherol derived from edible vegetable oils. Research indicates that the human body prefers the natural source Vitamin E, such as NOVATOL 5-87, over the synthetic forms. Moreover, based on the Food and Nutrition Board Expert Panel report on Vitamin E, d-alpha-tocopherol has twice the activity of synthetic forms, which means that natural Vitamin E is 100% more effective. (Dietary Reference Intakes For Vitamin C, Vitamin E, Selenium, and Carotenoids.2000. Vitamin E, National Academy Press, Washington, D.C., 186-283.) NOVATOL 5-87 is an essential nutrient and dietary supplement widely used in softgel capsules and liquid preparations.
ADM
NOVATOL HPMC
Flavor: characteristic
NOVATOL HPMC has little to no taste or odor and is a white to off-white crystalline powder. d-Alpha-Tocopherol is the form of tocopherol that is better retained in human tissues. It is the only form of alpha-tocopherol found in nature. The low viscosity and high concentration make d-alpha tocopherol ideal for soft gel capsules.
ADM
NOVATOL REGULAR GRADE
Flavor: characteristic
NOVATOL REGULAR GRADE has little to no taste or odor and is a white to off-white crystalline powder. d-Alpha-Tocopherol is the form of tocopherol that is better retained in human tissues. It is the only form of alpha-tocopherol found in nature. The low viscosity and high concentration make d-alpha tocopherol ideal for soft gel capsules.
Alfa Biotechnology
For experimental / research use only.
Vitamin E 98%
Ambles Nature et Chimie
ALPHA TOCOPHEROL NAT
American International Chemical, LLC.
Natural Vitamin E Alcohol 1000IU Light USP
BOC Sciences
For experimental / research use only.
a-Tocophenol
Jiangyin Healthway
Natural Vitamin E
New functional food ingredients
OQEMA
Vitamin E
Sigma-Aldrich: Sigma
For experimental / research use only.
(+)-a-Tocopherol from vegetable oil, Type V, ∼1000 IU/g
Sinoway Industrial
For experimental / research use only.
Natural vitamin E
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antioxidants and preservatives for fragrance and flavor
Recommendation for alpha-tocophenol usage levels up to:
 not for fragrance use.
 
Recommendation for alpha-tocophenol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Inability to assess the safety of beta-, gamma- and delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol added for nutritional purposes as sources of beta-, gamma- and delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl- tocotrienol in food supplements and the bioavailability of beta-, gamma-, delta- tocopherol and alpha-, beta-, gamma-, delta- and desmethyl-tocotrienol from the different sources, based on the supporting dossiers [1]
View page or View pdf

Opinion on mixed tocopherols, tocotrienol tocopherol and tocotrienols as sources for vitamin E added as a nutritional substance in food supplements[1] - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing aids and Materials in Contact with food (AFC)
View page or View pdf

Scientific Opinion on the safety and efficacy of tocopherol-rich extracts of natural origin, tocopherol-rich extracts of natural origin/delta rich, synthetic tocopherol for all animal species
View page or View pdf

Scientific Opinion on the safety and efficacy of synthetic alpha-tocopherol for all animal species
View page or View pdf

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as a-tocopherol
View page or View pdf

Scientific Opinion on Dietary Reference Values for vitamin E as a-tocopherol
View page or View pdf

Scientific Opinion on the re-evaluation of tocopherol-rich extract (E 306), a-tocopherol (E 307), ?-tocopherol (E 308) and d-tocopherol (E 309) as food additives
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):59-02-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6033
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(2S)-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]chroman-6-ol
Chemidplus:0000059029
RTECS:DJ2900000 for cas# 59-02-9
 
References:
 (2S)-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]chroman-6-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:59-02-9
Pubchem (cid):6033
Pubchem (sid):134972125
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
Metabolomics Database:Search
KEGG (GenomeNet):C02477
HMDB (The Human Metabolome Database):HMDB01893
FooDB:FDB000565
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antioxidants
 
Occurrence (nature, food, other):note
 almond seed
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 anise tissue culture
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 apple fruit
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 avocado fruit
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 banana hull husk
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 barley
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 barley leaf
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 barley root
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 barley seed
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 barley sprout
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 barley tissue culture
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 bean black bean fruit
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 bean black bean leaf
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 bean field bean fruit
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 bean field bean leaf
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 beet leaf
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 beet root
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 blueberry fruit
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 broccoli asparagus broccoli leaf
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 brussel sprout leaf
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 cabbage leaf
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 cantaloupe fruit
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 caraway
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 cardamom seed
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 carrot leaf
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 carrot root
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 castor oil
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 celery leaf
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 celery seed
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 celery shoot
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 cherry sour cherry fruit
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 coconut seed
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 coconut seed oil
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 coffee bean
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 coriander
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 corn
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 corn fruit
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 corn oil
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 corn seed
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 corn seed oil
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 cotton levant cotton seed oil
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 cranberry fruit
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 cress garden cress leaf
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 cress garden cress oil
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 cucumber fruit
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 currant black currant fruit
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 currant red currant fruit
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 dandelion leaf
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 dill leaf
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 evening-primrose seed
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 fennel
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 flax oil
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 flax seed oil
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 garlic bulb
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 grape
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 grape fruit
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 guava pineapple guava
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 hazelnut nut
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 hazelnut oil
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 hazelnut seed oil
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 kale siberian kale
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 leek wild leek plant
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 lettuce fruit
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 lychee
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 mandarin fruit
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 marango seed
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 mustard field mustard oil
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 oat seed
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 okra oil
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 okra seed
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 okra seed oil
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 olive oil
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 onion bulb
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 onion seed oil
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 orange fruit
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 oregano leaf
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 palm kernal oil
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 palm oil
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 papaya leaf
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 parsley leaf
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 peach fruit
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 peanut nut
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 peanut oil
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 peanut seed oil
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 pear fruit
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 pepper bell pepper fruit
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 pepper black pepper fruit
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 pepper black pepper sap
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 pepper black pepper seed
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 peppermint leaf
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 pineapple fruit
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 pistachio nut
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 plum fruit
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 potato tuber
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 raspberry red raspberry fruit
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 rhubarb leaf
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 rhubarb plant
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 rice
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 rice bran oil
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 rice seed
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 roselle seed
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 rosemary leaf
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 rye
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 safflower oil
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 safflower seed oil
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 sesame oil
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 sesame seed
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 sesame seed oil
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 soybean cotyledon
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 soybean leaf
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 soybean oil
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 soybean seed
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 soybean seed coat
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 soybean seed oil
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 spinach leaf
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 sunflower oil
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 sunflower seed oil
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 tomato fruit
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 turmeric root
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 walnut english walnut
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 walnut english walnut nut
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 walnut english walnut oil
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 wheat germ oil
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 wheat oil
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 wheat seed
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Synonyms:
 almefrol
 aquasol E
2H-1-benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]-, (2S)-
 denamone
3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol
 emipherol
 endo E
 etamican
 evitaminum
 phytogermine
 profecundin
 syntopherol
(S)-2,5,7,8-tetramethyl-2-((4R,8S)-4,8,12-trimethyl-tridecyl)-chroman-6-ol
(2S)-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol
(2S)-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]chroman-6-ol
(+)-a-tocopherol
(+)-alpha-tocopherol
D-a-tocopherol
D-alphatocopherol
D-alpha-tocopherol
dextro-alphatocopherol
 tokopharm
 vascuals
natural vitamin E
natural vitamin E alcohol 1000iu light USP
natural vitamin E alcohol 1000iu USP
 vitamin E alpha
 vitaplex E
 

Articles:

PubMed:Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
J-Stage:a-Tocopherol Sensitizes Human Leukemia HL-60 Cells to Apoptosis Induced by Benzyl Isothiocyanate
PubMed:Salvage therapy trial for erectile dysfunction using phosphodiesterase type 5 inhibitors and vitamin E: preliminary report.
PubMed:Silver halide fiber-based evanescent-wave liquid droplet sensing with room temperature mid-infrared quantum cascade lasers.
PubMed:Degeneration of dopaminergic neurons in the substantia nigra of zitter mutant rat and protection by chronic intake of Vitamin E.
PubMed:Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide.
PubMed:[Case-control study of markers of oxidative stress and metabolism of blood iron in Parkinson's disease].
PubMed:Cholesterol oxides in processed chicken muscle as influenced by dietary α-tocopherol supplementation.
PubMed:IR and turbidity studies of vitamin E-cholesterol-phospholipid membrane interactions.
PubMed:Iron(II)/reductant(DH2)-induced activation of dioxygen for the hydroxylation and ketonization of hydrocarbons; mimics for the cytochrome P-450 hydroxylase/reductase system.
PubMed:[A change in erythrocyte membrane permeability in rodents under the influence of fish oil, vitamin E and fatty acids].
PubMed:[Experimental study on cadmium poisoning (1): dynamics of serum tocophenol in cadmium poisoning with special reference to the influence of castration].
 
Notes:
a natural tocopherol and one of the most potent antioxidant tocopherols. it exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2h-1-benzopyran-6-ol nucleus. it has four methyl groups on the 6-chromanol nucleus. the natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture. Constit. of many vegetable oils such as soya and sunflower oils. Dietary supplement and nutrient. Nutriceutical with anticancer and antioxidant props. Added to fats and oils to prevent rancidity. The naturally-occurring tocopherol is a single stereoisomer; synthetic forms are a mixt. of all eight possible isomers Alpha-tocopherol is traditionally recognized as the most active form of vitamin E in humans, and is a powerful biological antioxidant.
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