|
Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellow crystals (est) |
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 147.00 to 148.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 448.00 to 449.00 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 437.00 °F. TCC ( 225.10 °C. ) (est)
|
| logP (o/w): | 1.407 (est) |
| Soluble in: |
| | alcohol | | | water, 315.3 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for isopimpinellin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for isopimpinellin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4,9- | dimethoxy-7H-furo(3,2-g) (1)benzopyran-7-one | | 4,9- | dimethoxy-7H-furo[3,2-g][1]benzopyran-7-one | | 4,9- | dimethoxy-7H-furo[3,2-g]chromen-7-one | | 4,9- | dimethoxy-furo[3,2-g]chromen-7-one | | 5,8- | dimethoxyfurano-2,3,6,7-coumarin | | 5,9- | dimethoxyfurano[3,2-g]chromen-2-one | | 4,9- | dimethoxyfuro[3,2-g]chromen-7-one | | 4,9- | dimethoxypsoralen | | 5,8- | dimethoxypsoralen | | 5,8- | dimethoxypsoralene | | 7H- | furo(3,2-g)(1)benzopyran-7-one, 4,9-dimethoxy- (8CI)(9CI) | | 7H- | furo[3,2-g][1]benzopyran-7-one, 4,9-dimethoxy- |
Articles:
| PubMed:[Chemical constituents of Angelica nitida roots]. |
| PubMed:Furocoumarins and coumarins photoinactivate Colletotrichum acutatum and Aspergillus nidulans fungi under solar radiation. |
| PubMed:Optimal extraction and fingerprint analysis of Cnidii fructus by accelerated solvent extraction and high performance liquid chromatographic analysis with photodiode array and mass spectrometry detections. |
| PubMed:The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins. |
| PubMed:5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. |
| PubMed:Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae. |
| PubMed:Essential oil composition and larvicidal activity of Toddalia asiatica roots against the mosquito Aedes albopictus (Diptera: Culicidae). |
| PubMed:Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents. |
| PubMed:Separation and purification of furanocoumarins from Toddalia asiatica (L.) Lam. using microwave-assisted extraction coupled with high-speed counter-current chromatography. |
| PubMed:Pressurized liquid extraction of coumarins from fruits of Heracleum leskowii with application of solvents with different polarity under increasing temperature. |
| PubMed:Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract. |
| PubMed:Furanocoumarins in celeriac from different farming systems: a 3-year study. |
| PubMed:Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti. |
| PubMed:Biological activities of Indian celery, Seseli diffusum (Roxb. ex Sm.) Sant. & Wagh. |
| PubMed:Microbial transformation of Isopimpinellin by Glomerella cingulata. |
| PubMed:Effects of furanocoumarins from apiaceous vegetables on the catalytic activity of recombinant human cytochrome P-450 1A2. |
| PubMed:Furanocoumarins from Dorsteniafoetida. |
| PubMed:Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms. |
| PubMed:Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells. |
| PubMed:Simultaneous and sensitive determination of xanthotoxin, psoralen, isoimpinellin and bergapten in rat plasma by liquid chromatography-electrospray ionization mass spectrometry. |
| PubMed:Application of the concept of relative photomutagenic potencies to selected furocoumarins in V79 cells. |
| PubMed:Botanical origin of Indian celery seed (fruit). |
| PubMed:Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice. |
| PubMed:Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermedius in Carassius auratus. |
| PubMed:Effects of naturally occurring coumarins on hepatic drug-metabolizing enzymes in mice. |
| PubMed:In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon. |
| PubMed:Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors. |
| PubMed:[Simultaneous determination of 5 active components in Fructus Cnidii by HPLC]. |
| PubMed:[Studies on the chemical constituents of the aerial parts of Seseli mairei]. |
| PubMed:[Studies on chemical constituents from fruits of Paliurus ramosissimus]. |
| PubMed:[Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro]. |
| PubMed:Simultaneous determination of urinary metabolites of methoxypsoralens in human and Umbelliferae medicines by high-performance liquid chromatography. |
| PubMed:[Studies on chemical constituents in roots of Heracleum rapula]. |
| PubMed:Cytochrome P450-mediated metabolism of xanthotoxin by Papilio multicaudatus. |
| PubMed:Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland. |
| PubMed:Accumulation of biologically active furanocoumarins in agitated cultures of Ruta graveolens L. and Ruta graveolens ssp. divaricata (Tenore) Gams. |
| PubMed:Melanogenesis stimulation in murine b16 melanoma cells by umberiferae plant extracts and their coumarin constituents. |
| PubMed:Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants. |
| PubMed:Accumulation of biologically active furanocoumarins in Ruta graveolens ssp. divaricata (Tenore) Gams in vitro culture. |
| PubMed:Natural furocoumarins as inducers and inhibitors of cytochrome P450 1A1 in rat hepatocytes. |
| PubMed:Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography. |
| PubMed:[Quantification of isopimpinellin in root of Toddalia asiatica by HPLC]. |
| PubMed:Insecticidal effect of phthalides and furanocoumarins from Angelica acutiloba against Drosophila melanogaster. |
| PubMed:Computer-assisted, high-performance liquid chromatography with mass spectrometric detection for the analysis of coumarins in Peucedanum palustre and Angelica archangelica. |
| PubMed:[Studies on the coumarins in the root of Zanthoxylum dimorphophyllum]. |
| PubMed:The furanocoumarins in the roots of Heracleum sibiricum L. |
| PubMed:Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines. |
| PubMed:LC determination of impurities in methoxsalen drug substance: isolation and identification of isopimpinellin as a major impurity by atmospheric pressure chemical ionization LC/MS and NMR. |
| PubMed:Constituents of Peucedanum zenkeri seeds and their antimicrobial effects. |
| PubMed:Naturally occurring coumarins inhibit human cytochromes P450 and block benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene DNA adduct formation in MCF-7 cells. |
| PubMed:A new dicoumarinyl ether and two rare furocoumarins from Ruta montana. |
| PubMed:HPLC-NMR/HPLC-MS analysis of the bark extract of Stauranthus perforatus. |
| PubMed:[Isolation and identification of active constituent of Toddalia asiatica in cardiovascular system]. |
| PubMed:Constituents of the fruits and leaves of Euodia daniellii. |
| PubMed:Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice. |
| PubMed:Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase. |
| PubMed:Effects of storage conditions on furocoumarin levels in intact, chopped, or homogenized parsnips. |
| PubMed:Bullous phytophotodermatitis associated with high natural concentrations of furanocoumarins in limes. |
| PubMed:Simultaneous determination of furanocoumarins in infusions and decoctions from "Carapiá" (dorstenia species) by high-performance liquid chromatography. |
| PubMed:Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON). |
| PubMed:Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation. |
| PubMed:Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice. |
| PubMed:Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum. |
| PubMed:Oral administration of naturally occurring coumarins leads to altered phase I and II enzyme activities and reduced DNA adduct formation by polycyclic aromatic hydrocarbons in various tissues of SENCAR mice. |
| PubMed:Coumarin compounds in Ammi majus L. callus cultures. |
| PubMed:Furanocoumarins in Pastinaca sativa L. in vitro culture. |
| PubMed:Cytotoxic components from the bark of Stauranthus perforatus from Monteverde, Costa Rica. |
| PubMed:Rapid determination of furanocoumarins in creams and pomades using SPE and GC. |
| PubMed:Isolation And Structure Elucidation Of 5,7-disubstituted Simple Coumarins In The Fruits Of Heracleum Mantegazzianum. |
| PubMed:Effect of naturally occurring coumarins on the formation of epidermal DNA adducts and skin tumors induced by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene in SENCAR mice. |
| PubMed:Isolation and characterization of CYP6B4, a furanocoumarin-inducible cytochrome P450 from a polyphagous caterpillar (Lepidoptera:papilionidae). |
| PubMed:Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. |
| PubMed:Isolation and identification of antimicrobial furocoumarins from parsley. |
| PubMed:Development of an immunoassay to measure the absorption of dietary furanocoumarins in humans. |
| PubMed:Isopimpinellin is not phototoxic in a chick skin assay. |
| PubMed:Analysis, isolation and insecticidal activity of linear furanocoumarins and other coumarin derivatives fromPeucedanum (Apiaceae: Apioideae). |
| PubMed:Inhibition and inactivation of murine hepatic ethoxy- and pentoxyresorufin O-dealkylase by naturally occurring coumarins. |
| PubMed:Phototoxic coumarins in limes. |
| PubMed:Differential inhibition of coumarin 7-hydroxylase activity in mouse and human liver microsomes. |
| PubMed:[Studies on the chemical constituents of Rutaceae++ plants. LXVI. The chemical constituents of Toddalia asiatica (L.) Lam. (T. aculeata Pers.). (1). Chemical constituents of the root bark]. |
| PubMed:Phototoxicity due to Cachrys libanotis. |
| PubMed:Host plant resistance and linear furanocoumarin content of Apium accessions. |
| PubMed:Impact of atmospheric pollution on linear furanocoumarin content in celery. |
| PubMed:Heracleum mantegazzianum growth phases and furocoumarin content. |
| PubMed:Artificial defloration and furanocoumarin induction inPastinaca sativa (Umbelliferae). |
| PubMed:Isopimpinellin is not phototoxic to viruses and cells. |
| PubMed:Oxypeucedanin, a Major Furocoumarin in Parsley, Petroselinum crispum. |
| PubMed:[Isopimpinellin--a furocoumarin from Heracleum sphondylium with chromosome damaging activity]. |
| PubMed:Biologically active principles of crude drugs. Anti-allergic principles in "Cnidii monnieri". |
| PubMed:Identification of psoralen, 8-methoxypsoralen, isopimpinellin, and 5,7-dimethoxycoumarin in Pelea anisata H. Mann. |
| PubMed:Furocoumarins of Heracleum laciniatum: isolation, phototoxicity, absorption and action spectra studies. |
| PubMed:The furocoumarin composition of Pituranthos triradiatus. |
| PubMed:HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). |
| PubMed:Differential response of cultured parsley cells to elicitors from two non-pathogenic strains of fungi. 1. Identification of induced products as coumarin derivatives. |
| PubMed:The biosynthesis of isopimpinellin. |
| PubMed:Isolation of isopimpinellin from the fruits of Ammi majus L. natural coumarins. IV. |
|
3D/inchi