EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sodium sulfite
sulfurous acid sodium salt (1:2)

Supplier Sponsors

Name:disodium sulfite
CAS Number: 7757-83-7Picture of molecule3D/inchi
Other(deleted CASRN):68135-69-3
ECHA EINECS - REACH Pre-Reg:231-821-4
FDA UNII: VTK01UQK3G
Nikkaji Web:J3.108I
MDL:MFCD00003503
Molecular Weight:126.04213856
Formula:Na2 O3 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antibrowning agents, antioxidants, preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
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NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
182.3798 Sodium sulfite View - review
EU SANCO Sodium sulphite View - review
JECFA Food Additive: Sodium Sulfite
GSFA Codex: Sodium sulfite (221)
DG SANTE Food Additives:sodium sulphite
DG SANTE Food Contact Materials:sodium sulphite
FDA Mainterm (SATF):7757-83-7 ; SODIUM SULFITE
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1200 Cellophane.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart D--Chemical Preservatives
Sec. 182.3798 Sodium sulfite.


FDA PART 73 -- LISTING OF COLOR ADDITIVES EXEMPT FROM CERTIFICATION
Subpart A--Foods
Sec. 73.85 Caramel.
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, slightly
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair straightening agents
hair waving agents
preservatives
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Sodium sulfite 98%
American Elements
Sodium Sulfite 99%
Odor: characteristic
Use: Sodium Sulfite is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. We also produce Sodium Sulfite Solution. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
BOC Sciences
For experimental / research use only.
Sodium sulfite anhydrous
Charkit Chemical
SODIUM SULFITE
Covalent Chemical
Sodium Sulfite
ECSA Chemicals
SODIUM SULPHITE ANHYDROUS 47/49% SO2
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
SODIUM SULPHITE ANHYDROUS RPE-ACS-FOR ANALYS
ECSA Chemicals
SODIUM SULPHITE ANHYDROUS RPH- PH.EUR.-BP,
EMD Millipore
For experimental / research use only.
Sodium Sulfite
sds
Glentham Life Sciences
Sodium sulfite, anhydrous
Graham Chemical
Sodium Sulfite
Penta International
SODIUM SULFITE ANHYDROUS GRANULAR FCC
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Sulfite
Sigma-Aldrich
For experimental / research use only.
Sodium Sulfite ≥98%
Strem Chemicals
For experimental / research use only.
Sodium sulfite, anhydrous, 98+% (ACS)
Wedor Corporation
SODIUM SULFITE
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3560 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
International Journal of Toxicology. Vol. 19, Pg. 349, 2000.

oral-mouse LD50 820 mg/kg
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 27, Pg. 159, 1976.

intravenous-mouse LD50 175 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 101, 1951.

intravenous-cat LDLo 400 mg/kg
Archiv fuer Hygiene. Vol. 57, Pg. 87, 1906.

intravenous-guinea pig LDLo 200 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

intraperitoneal-mouse LD50 950 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1713, 1981.

oral-rabbit LDLo 2825 mg/kg
Archiv fuer Hygiene. Vol. 57, Pg. 87, 1906.

Dermal Toxicity:
subcutaneous-cat LDLo 1300 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

subcutaneous-dog LDLo 1300 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

subcutaneous-guinea pig LDLo 600 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.

subcutaneous-rabbit LDLo 600 mg/kg
Archiv fuer Hygiene. Vol. 57, Pg. 87, 1906.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antibrowning agents, antioxidants, preservatives
Recommendation for sodium sulfite usage levels up to:
 not for fragrance use.
 
Recommendation for sodium sulfite flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium metabisulfite (E 223), potassium metabisulfite (E 224), calcium sulfite (E 226), calcium bisulfite (E 227) and potassium bisulfite (E 228) as food additives
View page or View pdf

EPI System: View
Daily Med:search
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):7757-83-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24437
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
disodium sulfite
Chemidplus:0007757837
EPA/NOAA CAMEO:hazardous materials
RTECS:7757-83-7
 
References:
 disodium sulfite
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7757-83-7
Pubchem (cid):24437
Pubchem (sid):134989837
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D09002
HMDB (The Human Metabolome Database):Search
FooDB:FDB015396
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
FAO:SODIUM SULFITE
Formulations/Preparations:
•grades: reagent; technical; fcc. •general chem corp (previously allied), stauffer, & va chem produce a technical grade sodium sulfite anhydrous with a minimum typical analysis of 96.5%, granular technical has a typical analysis of 98.0% with food & photographic grades at 98.6%. koppers supplies on-purpose material made from sulfur dioxidewith an analysis of 96-97%koppers also produces 89-91% material as a by-product of resorcinol manufacture...
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 disodium sulfite
 disodium sulfite (Na2SO3)
monosodium sulfite
 sodium sulfite anhydrous granular
 sodium sulphite
 sodiumsulfite
 sulftech
 sulfurous acid disodium salt
 sulfurous acid sodium salt
 sulfurous acid sodium salt (1:2)
 sulfurous acid, disodium salt
 

Articles:

PubMed:Formation and reduction of furan in a soy sauce model system.
PubMed:Anaerobic digestion of wastewater from the fruit juice industry: experiments and modeling.
PubMed:Fibrous polymer grafted magnetic chitosan beads with strong poly(cation-exchange) groups for single step purification of lysozyme.
PubMed:Dissociation and reduction of covalent β-lactoglobulin-quinone adducts by dithiothreitol, tris(2-carboxyethyl)phosphine, or sodium sulfite.
PubMed:Effects of sulfhydryl compounds, carbohydrates, organic acids, and sodium sulfite on the formation of lysinoalanine in preserved egg.
PubMed:Oral drug delivery of therapeutic gases - carbon monoxide release for gastrointestinal diseases.
PubMed:Reduction of carcinogenic 4(5)-methylimidazole in a caramel model system: influence of food additives.
PubMed:Decreased immunoglobulin E (IgE) binding to cashew allergens following sodium sulfite treatment and heating.
PubMed:Development of crayfish bio-based plastic materials processed by small-scale injection moulding.
PubMed:Quantum dots as a possible oxygen sensor.
PubMed:Determination of free sulfites (SO3-2) in dried fruits processed with sulfur dioxide by ion chromatography through anion exchange column and conductivity detection.
PubMed:On-line redox derivatization liquid chromatography for selective separation of Fe(II) and Fe(III) cyanide complexes using porous graphitic carbon.
PubMed:Formation of 4(5)-methylimidazole and its precursors, α-dicarbonyl compounds, in Maillard model systems.
PubMed:Improvement and validation of the method to determine neutral detergent fiber in feed.
PubMed:FdhTU-modulated formate dehydrogenase expression and electron donor availability enhance recovery of Campylobacter jejuni following host cell infection.
PubMed:Optimal production of L-threo-2,3-dihydroxyphenylserine (L-threo-DOPS) on a large scale by diastereoselectivity-enhanced variant of L-threonine aldolase expressed in Escherichia coli.
PubMed:Purification and characterization of polyphenol oxidase from rape flower.
PubMed:Comparison of common lignin methods and modifications on forage and lignocellulosic biomass materials.
PubMed:Bioplastics from feather quill.
PubMed:Food additives such as sodium sulphite, sodium benzoate and curcumin inhibit leptin release in lipopolysaccharide-treated murine adipocytes in vitro.
PubMed:Effect of antibrowning agents on browning and intermediate formation in the glucose-glutamic acid model.
PubMed:A multipathogen selective enrichment broth for simultaneous growth of Salmonella spp., Vibrio parahaemolyticus, and Vibrio cholerae.
PubMed:Rapid microplate high-throughput methodology for assessment of Folin-Ciocalteu reducing capacity.
PubMed:[A multipathogen selective enrichment broth (SVV) for simultaneous growth of Salmonella, Vibrio parahaemolyticus, and Vibrio cholerae].
PubMed:Effects of sulfur dioxide derivatives on expression of oncogenes and tumor suppressor genes in human bronchial epithelial cells.
PubMed:Effects of chemical composition variation on the dynamics of ruminal fermentation and biological value of corn milling (co)products.
PubMed:Application of multivariate analysis to the effects of additives on chemical and sensory quality of stored coffee brew.
PubMed:Determination of free and reversibly-bound sulfite in selected foods by high-performance liquid chromatography with fluorometric detection.
PubMed:Kinetics of growth and leukotoxin production by Mannheimia haemolytica in continuous culture.
PubMed:Texture of cooked rice prepared from aged rice and its improvement by reducing agents.
PubMed:Fed-batch cultivation of the marine bacterium Sulfitobacter pontiacus using immobilized substrate and purification of sulfite oxidase by application of membrane adsorber technology.
PubMed:Food preservatives sodium sulfite and sorbic acid suppress mitogen-stimulated peripheral blood mononuclear cells.
PubMed:Stability of barley and malt lipid transfer protein 1 (LTP1) toward heating and reducing agents: relationships with the brewing process.
PubMed:An optimized enumeration method for sorbitol-fermenting Bifidobacteria in water samples.
PubMed:Comparative study on the use of ortho-phthalaldehyde, naphthalene-2,3-dicarboxaldehyde and anthracene-2,3-dicarboxaldehyde reagents for alpha-amino acids followed by the enantiomer separation of the formed isoindolin-1-one derivatives using quinine-type chiral stationary phases.
PubMed:Determination of carbofuran by flow-injection with chemiluminescent detection.
PubMed:Identification of factors involved in recovery of heat-injured Salmonella Enteritidis.
PubMed:Evaluation of a simple membrane-based nucleic acid preparation protocol for RT-PCR detection of potato viruses from aphid and plant tissues.
PubMed:[Study on extraction and stability of pigment from flowers of Leucosceptrum canum].
PubMed:Fast kinetic determination of 1-naphthylacetic acid in commercial formulations, soils, and fruit samples using stopped-flow phosphorimetry.
PubMed:The effect of vitamin E supplementation on discoloration of injection-site lesions in retail cuts and the greening reaction observed in injection-site lesions in muscles of the chuck.
PubMed:Determination of the amino acid tryptophan and the biogenic amine tryptamine in foods by the heavy atom induced-room temperature phosphorescence methodology.
PubMed:Controlled release of oxytetracycline in sheep.
PubMed:[Colorimetric determination of sulfite in "kanpyo" (dried gourd shavings) and "konnyakuseiko" (devil's-tongue fine powder) using sulfite oxidase and catalase].
PubMed:[Spore rec-assay by dry sheet medium culture plate for bacterial counts].
PubMed:Determination of the pesticide napropamide in soil, pepper, and tomato by micelle-stabilized room-temperature phosphorescence.
PubMed:Sodium sulphite inhibition of potato and cherry polyphenolics in nucleic acid extraction for virus detection by RT-PCR.
PubMed:[Microbiological stability study of minimally processed cantaloupe (Cucumis melo L) by vacuum].
PubMed:Analysis and stability of carotenoids in the flowers of daylily (Hemerocallis disticha) as affected by various treatments.
PubMed:Method for the Quantitative Determination of 1-Naphthaleneacetic Acid in Spiked Canned Pineapple Samples by Micelle-Stabilized Room Temperature Phosphorescence.
PubMed:[In vitro study of the interference of certain food components with the metabolism of aflatoxin B1].
PubMed:Protein insolubilization and thiol oxidation in sulfite-treated wheat gluten films during aging at various temperatures and relative humidities.
PubMed:Chemistry, biochemistry, nutrition, and microbiology of lysinoalanine, lanthionine, and histidinoalanine in food and other proteins.
PubMed:Activation of the superoxide-generating NADPH oxidase of intestinal lymphocytes produces highly reactive free radicals from sulfite.
PubMed:Lysinoalanine in food and in antimicrobial proteins.
PubMed:Growth and toxin production by Clostridium botulinum on sliced raw potatoes in a modified atmosphere with and without sulfite.
PubMed:Effects of sodium sulfite on recovery and composition of detergent fiber and lignin.
PubMed:Enhancement of ethylenethiourea recoveries in food analyses by addition of cysteine hydrochloride.
PubMed:Evaluation of phototoxic properties of some food additives: sulfites exhibit prominent phototoxicity.
PubMed:Evaluation of teratogenic potential of sodium sulfite in rats.
PubMed:[Inhibition of methanogenesis in the rumen of sheep. II. Methanogenesis after administration of inhibitors].
PubMed:Sulfite suppresses the mutagenic property of coffee.
PubMed:Cytogenetic effects of the food preservatives--sodium benzoate and sodium sulphite on Vicia faba root meristems.
PubMed:DNA and its precursors might interact with the food preservatives, sodium sulphite and sodium benzoate.
PubMed:Rapid screening procedure for the determination of preservatives in ground beef: sulfites, benzoates, sorbates, and ascorbates.
 
Notes:
Used as a sanitising agent for food containers and fermentation equipment, as a preservative to reduce or prevent microbial spoilage of food, as a selective inhibitor of undesirable microorganisms in the fermentation industries, and as an antioxidant and inhibitor of enzyme-catalysed oxidative discoloration and non-enzymic browning during prepn., storage and distribution of foods
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