EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sodium salicylate
2-hydroxybenzoic acid, monosodium salt

Supplier Sponsors

Name:sodium;2-hydroxybenzoate
CAS Number: 54-21-7Picture of molecule3D/inchi
Other(deleted CASRN):18495-69-7
ECHA EINECS - REACH Pre-Reg:200-198-0
FDA UNII: WIQ1H85SYP
Beilstein Number:3732792
MDL:MFCD00002440
Molecular Weight:160.10421928
Formula:C7 H5 Na O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FCN 634 Benzoic acid, 2-hydroxy, monosodium salt View - notice
FCN 802 Benzoic acid, 2-hydroxy-, monosodium salt View - notice
FDA Mainterm (IAUFC):54-21-7 ; SODIUM SALICYLATE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 213.00 °C. @ 760.00 mm Hg
Boiling Point: 336.30 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000044 mmHg @ 25.00 °C. (est)
Flash Point: 292.00 °F. TCC ( 144.50 °C. ) (est)
logP (o/w): 2.061 (est)
Soluble in:
 water, 1.25E+05 mg/L @ 25 °C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: denaturants
preservatives
 
Suppliers:
American Elements
Sodium Salicylate 99%
Odor: characteristic
Use: Sodium Salicylate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
BOC Sciences
For experimental / research use only.
Sodium salicylate >98%
Odor: characteristic
Use: Sodium salicylate is used in medicine as an analgesic and antipyretic.
Charkit Chemical
SODIUM SALICYLATE USP
EMD Millipore
For experimental / research use only.
Sodium Salicylate
sds
Glentham Life Sciences
Sodium salicylate, Ph. Eur. grade
Glentham Life Sciences
Sodium salicylate
Penta International
SODIUM SALICYLATE USP
Penta International
SODIUM SALICYLATE USP/EP GRADE
Penta International
SODIUM SALICYLATE
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Salicylate 99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Sodium Salicylate ReagentPlus®, ≥99.5%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 562 mg/kg
BEHAVIORAL: ANALGESIA
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964.

intraperitoneal-dog LDLo 990 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

oral-dog LDLo 450 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

intraperitoneal-guinea pig LDLo 900 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

oral-human LDLo 700 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
New England Journal of Medicine. Vol. 232, Pg. 617, 1945.

intramuscular-mouse LD50 760 mg/kg
Acta Paediatrica Scandinavica. Vol. 59, Pg. 517, 1970.

intraperitoneal-mouse LD50 500 mg/kg
Strahlentherapie. Vol. 127, Pg. 245, 1965.

intravenous-mouse LD50 500 mg/kg
British Patent Document. Vol. #1009195

oral-mouse LD50 540 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955.

intravenous-rabbit LD50 415 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.

oral-rabbit LD50 1700 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 89, Pg. 205, 1947.

intraperitoneal-rat LD50 542 mg/kg
Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 791, 1979.

oral-rat LD50 930 mg/kg
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

Dermal Toxicity:
subcutaneous-dog LDLo 200 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-frog LDLo 250 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1392, 1935.

subcutaneous-guinea pig LDLo 800 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: EXCITEMENT CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)
Revue Medicale de la Suisse Romande. Vol. 15, Pg. 561, 1895.

subcutaneous-mouse LD50 550 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for sodium salicylate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium salicylate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):54-21-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :16760658
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
sodium;2-hydroxybenzoate
Chemidplus:0000054217
RTECS:VO5075000 for cas# 54-21-7
 
References:
 sodium;2-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:54-21-7
Pubchem (cid):16760658
Pubchem (sid):134971649
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07587
HMDB (The Human Metabolome Database):Search
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 alysine
 ardall
 aroall
 benzoic acid, 2-hydroxy-, monosodium salt
 benzoic acid, 2-hydroxy-, sodium salt (1:1)
 camporisin
 enterosalicyl
 enterosalil
 entrosalyl
 glutosalyl
2-hydroxybenzoic acid monosodium salt
o-hydroxybenzoic acid monosodium salt
2-hydroxybenzoic acid sodium salt
2-hydroxybenzoic acid, monosodium salt
 idocyl novum
 kerasalicyl
 kerosal
 magsalyl
 nadisal
 pabalate
 parbocyl-rev
neo-salicyl
 salicylic acid monosodium salt
 salicylic acid sodium salt
 salicylic acid, monosodium salt
 salicylic acid, sodium salt
 salisod
 salsonin
monosodium 2-hydroxybenzoate
 sodium o-hydroxybenzoate
 sodium ortho-hydroxybenzoate
monosodium salicylate
 sodium salicylate USP
 sodium;2-hydroxybenzoate
 sodiumsalicylate
 

Articles:

PubMed:Assessment of ABCG2-mediated transport of xenobiotics across the blood-milk barrier of dairy animals using a new MDCKII in vitro model.
PubMed:[New drugs for horses and production animals in 2011].
PubMed:Effective induction of oral anaphylaxis to ovalbumin in mice sensitized by feeding of the antigen with aid of oil emulsion and salicylate.
PubMed:Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.
PubMed:Food-derived bioactives as potential regulators of the IL-12/IL-23 pathway implicated in inflammatory bowel diseases.
PubMed:Effect of Hofmeister anions on micellization and micellar growth of the surfactant cetylpyridinium chloride.
PubMed:Linear-to-branched micelles transition: a rheometry and diffusing wave spectroscopy (DWS) study.
PubMed:Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli.
PubMed:Ultrasound velocimetry in a shear-thickening wormlike micellar solution: evidence for the coexistence of radial and vorticity shear bands.
PubMed:Ion chromatographic determination of organic acids in food samples using a permanent coating graphite carbon column.
PubMed:Efflux pump activity in fluoroquinolone and tetracycline resistant Salmonella and E. coli implicated in reduced susceptibility to household antimicrobial cleaning agents.
PubMed:Can high-performance liquid chromatography coupled with fluorescence detection under all conditions be regarded as a sufficiently conclusive confirmatory method for B-group substances?
PubMed:Salicylate activity. 2. Potentiation of atrazine.
PubMed:Salicylate activity. 1. Protection of plants from paraquat injury.
PubMed:Stress driven shear bands and the effect of confinement on their structures--a rheological, flow visualization, and Rheo-SALS study.
PubMed:Sodium salicylate attenuates lipopolysaccharide (LPS)-induced adipsia, but not hypophagia, in broiler chickens.
PubMed:Environmental regulation of Campylobacter jejuni major outer membrane protein porin expression in Escherichia coli monitored by using green fluorescent protein.
PubMed:Rapid and specific detection of hydroxyl radical using an ultraweak chemiluminescence analyzer and a low-level chemiluminescence emitter: application to hydroxyl radical-scavenging ability of aqueous extracts of Food constituents.
PubMed:Inhibitory effect of sodium salicylate on nitric oxide production from TM4 sertoli cells.
PubMed:Postnatal evolution of supernumerary ribs in rats after a single administration of sodium salicylate.
PubMed:Induction of supernumerary ribs with sodium salicylate.
PubMed:Behavioral model of chronic tinnitus in rats.
PubMed:Immune cytokines and regulation of body temperature, food intake and cellular immunity.
PubMed:Chemically induced alterations in maternal homeostasis and histology of conceptus: their etiologic significance in rat fetal anomalies.
PubMed:Acute toxicity testing in the nonlethal dose range: a new approach.
PubMed:Effects of dietary sodium selenite supplementation on salicylate-induced embryo- and fetotoxicity in the rat.
PubMed:The induction of supernumerary ribs in rodents: role of the maternal stress.
PubMed:[Adverse reactions to food preservatives].
PubMed:The role of fever in appetite suppression after endotoxin administration.
PubMed:Sodium salicylate and aspirin disease.
PubMed:Strategy for the assessment of neurobehavioral consequences of environmental factors.
PubMed:Histological changes in the skeletal elements of developing rat foetuses following treatment with sodium salicylate.
PubMed:Effect of sodium salicylate on the food and oxygen consumption of rats.
PubMed:THE INFLUENCE OF BILE ON METABOLISM.
 
Notes:
a compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. it has bacteriostatic, fungicidal, and keratolytic actions. its salts, the salicylates, are used as analgesics. (from dorland's, 28th ed) a non-steroidal anti-inflammatory agent that is less effective than equal doses of aspirin in relieving pain and reducing fever. however, individuals who are hypersensitive to aspirin may tolerate sodium salicylate. in general, this salicylate produces the same adverse reactions as aspirin, but there is less occult gastrointestinal bleeding. (from ama drug evaluations annual, 1992, p120)
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