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Category:nutrient supplements, EFSA concludes: use is of safety concern.
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 345.00 to 346.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 656.00 to 657.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 664.00 °F. TCC ( 351.10 °C. ) (est)
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| logP (o/w): | -0.830 |
| Soluble in: |
| | water, 1820 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 2000 mg/kg
Drugs in Japan Vol. 6, Pg. 165, 1982.
intravenous-mouse LD50 770 mg/kg
Drugs in Japan Vol. 6, Pg. 165, 1982.
intraperitoneal-mouse LD50 841 mg/kg
Drugs in Japan Vol. 6, Pg. 165, 1982.
oral-mouse LD50 2000 mg/kg
Drugs in Japan Vol. 6, Pg. 165, 1982.
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | nutrient supplements, EFSA concludes: use is of safety concern. |
| Recommendation for orotic acid usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for orotic acid flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
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Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf
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Orotic acid salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements
View page or View pdf
|
| EPI System: View |
| ClinicalTrials.gov:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):65-86-1 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :967 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 2,4-dioxo-1H-pyrimidine-6-carboxylic acid |
| Chemidplus:0000065861 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:RM3180000 for cas# 65-86-1 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 6- | carboxyuracil | | 2,6- | dihydroxy-4-pyrimidinecarboxylic acid | | 2,6- | dihydroxy-pyrimidine-4-carboxylic acid | | 2,6- | dihydroxypyrimidine-4-carboxylic acid | | 2,6- | dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylic acid | | 2,6- | dioxo-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid | | 2,6- | dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | | 2,6- | dioxo-1,3-dihydropyrimidine-4-carboxylic acid | | 2,4- | dioxo-1H-pyrimidine-6-carboxylic acid | | 2,6- | dioxo(4-14c)-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid | | | molkensaeure | | | orotic acid anhydrous | | | orotic acid, anhydrous | | | oroticacid | | | orotsaeure | | 4- | pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo- | | 4- | pyrimidinecarboxylic acid, 2,6-dihydroxy- | | 1,2,3,6- | tetrahydro-2,6-dioxo-4-pyrimidecarboxylic acid | | 1,2,3,6- | tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid | | 1,2,3,4- | tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid | | 1,2,3,6- | tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid | | 6- | uracilcarboxylic acid | | | vitamin B13 | | | whey factor |
Articles:
| PubMed:The role of sodium in the salty taste of permeate. |
| PubMed:Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry. |
| PubMed:Controllable self-assembly of sodium caseinate with a zwitterionic vitamin-derived bolaamphiphile. |
| PubMed:Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milk. |
| PubMed:Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexis in rats. |
| PubMed:Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid. |
| PubMed:Growth and exopolysaccharide yield of Lactobacillus delbrueckii ssp. bulgaricus DSM 20081 in batch and continuous bioreactor experiments at constant pH. |
| PubMed:Isolation and anti-fatty liver activity of a novel cerebroside from the sea cucumber Acaudina molpadioides. |
| PubMed:Molecular recognition of melamine by vesicles spontaneously formed from orotic acid derived bolaamphiphiles. |
| PubMed:Study on possible mechanism of orotic acid-induced fatty liver in rats. |
| PubMed:[Effect of sea cucumber cerebroside on lipid metabolism in fatty liver rats]. |
| PubMed:Use of the pyrG gene as a food-grade selection marker in Monascus. |
| PubMed:Nucleotides and nucleosides in ovine and caprine milk during lactation. |
| PubMed:Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. |
| PubMed:Regulation of pyrimidine formation in Pseudomonas lundensis. |
| PubMed:Functional lipids and the prevention of the metabolic syndrome. |
| PubMed:The orotate transporter encoded by oroP from Lactococcus lactis is required for orotate utilization and has utility as a food-grade selectable marker. |
| PubMed:Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome with stroke-like imaging presentation: clinical, biochemical and molecular analysis. |
| PubMed:Transformation by complementation of a uracil auxotroph of the hyper lignin-degrading basidiomycete Phanerochaete sordida YK-624. |
| PubMed:Influence of calcium and phosphorus, lactose, and salt-to-moisture ratio on Cheddar cheese quality: changes in residual sugars and water-soluble organic acids during ripening. |
| PubMed:Adsorption of bile acid by chitosan-orotic acid salt and its application as an oral preparation. |
| PubMed:The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice. |
| PubMed:Dietary arginine supplementation enhances the growth of milk-fed young pigs. |
| PubMed:Quantification of non-protein nitrogen components of infant formulae and follow-up milks: comparison with cows' and human milk. |
| PubMed:Variation in organic acids content during ripening of pickled white cheese. |
| PubMed:Development of a CE method to analyze organic acids in dairy products: application to study the metabolism of heat-shocked spores. |
| PubMed:Behavior of alginate gel beads containing chitosan salt prepared with water-soluble vitamins. |
| PubMed:Ornithine carbamoyltransferase deficiency: improved sensitivity of testing for protein tolerance in the diagnosis of heterozygotes. |
| PubMed:Effects of dietary protein type on the response of lipid metabolism to orotic acid in rats. |
| PubMed:Mutagenic specificity of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in Escherichia coli using the yeast URA3 gene as a target. |
| PubMed:High-performance liquid chromatographic determination of orotic acid as its methyl derivative in human urine. |
| PubMed:Persistent hyperammonemia in two related Morgan weanlings. |
| PubMed:Nutritional and metabolic effects and significance of mild orotic aciduria during dietary supplementation with arginine or its organic salts after trauma injury in rats. |
| PubMed:Construction of a plasmid carrying both CTP synthetase and a fused gene formed from cholinephosphate cytidylyltransferase and choline kinase genes and its application to industrial CDP-choline production: enzymatic production of CDP-choline from orotic acid (Part II). |
| PubMed:Enzymatic production of pyrimidine nucleotides using Corynebacterium ammoniagenes cells and recombinant Escherichia coli cells: enzymatic production of CDP-choline from orotic acid and choline chloride (Part I). |
| PubMed:Antagonistic effect of nucleic acid precursors on the anticoccidial activity of 6-azauracil. |
| PubMed:A novel strategy for the isolation of defined pyrG mutants and the development of a site-specific integration system for Aspergillus awamori. |
| PubMed:Dietary citrulline but not ornithine counteracts dietary arginine deficiency in rats by increasing splanchnic release of citrulline. |
| PubMed:Dietary supplementation of L-arginine ameliorates renal hypertrophy in rats fed a high-protein diet. |
| PubMed:Glucagon administration in vivo stimulates hepatic RNA and protein breakdown in fed and fasted rats. |
| PubMed:Influence of orotic acid and estrogen on hepatic lipid storage and secretion in the goose susceptible to liver steatosis. |
| PubMed:Dietary arginine deficiency alters flux of glutamine and urea cycle intermediates across the portal-drained viscera and liver of rats. |
| PubMed:Production of vitamins, coenzymes and related biochemicals by biotechnological processes. |
| PubMed:Efficacy of ornithine-alpha-ketoglutarate (OKGA) as a dietary supplement in growing rats. |
| PubMed:Rates of rat liver RNA degradation in vivo as determined from cytidine release during brief cyclic perfusion in situ. |
| PubMed:The permeability properties of septate junctions in Malpighian tubules of Rhodnius. |
| PubMed:The orotic acid concentration in the blood, milk, and urine of dairy cows fed with urea supplemented diet. |
| PubMed:Natural history of symptomatic partial ornithine transcarbamylase deficiency. |
| PubMed:The effect of dietary protein on nitrogen and sulfur metabolism in portacaval-shunted rats. |
| PubMed:Orotic acid, arginine, and hepatotoxicity. |
| PubMed:Nuclear RNA polymerase activity in tumor-host livers. |
| PubMed:Orotic acid excretion during starvation and refeeding in normal men. |
| PubMed:Brain mRNA translatability in rats: changes during long-term dietary restriction in the developmental period of life. |
| PubMed:Effect of fasting on the metabolism of cytidine nucleotides in the liver of intact and alpha-hexachlorocyclohexane-treated rats. |
| PubMed:Purine and pyrimidine metabolism. |
| PubMed:[Neonatal hyperammonemia due to ornithine transcarbamylase deficiency (author's transl)]. |
| PubMed:Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet. |
| PubMed:Arginine: an indispensable amino acid for mature dogs. |
| PubMed:Effect of some dietary additions to either an arginine-devoid diet or a diet supplemented with orotic acid refed after starvation on liver lipid content during essential fatty acid deficiency in rats. |
| PubMed:Ammonia metabolism in a family affected by hyperargininemia. |
| PubMed:Hydra viridis: transfer of metabolites between Hydra and symbiotic algae. |
| PubMed:Arginine deficiency during gestation and lactation in the rat. |
| PubMed:Studies dealing with hepatic RNA metabolism in rats force-fed a threonine-devoid diet. |
| PubMed:Orotic acid content of infant formulas. |
| PubMed:Effect of dietary arginine level on urinary orotate and citrate excretion in growing kittens. |
| PubMed:Orotic acid and non-protein nitrogen overload in sheep. |
| PubMed:Avoidance reaction of painful stimulation of another rat: effect of methylglucamine orotate. |
| PubMed:Determination of orotic acid in whey and modified whey products. |
| PubMed:Arginine requirements in immature dogs. |
| PubMed:Lower gastric secretion and higher incorporation of orotic acid into liver RNA in rats treated with 5-azacytidine and cycloheximide. |
| PubMed:Nitrogen retention in rats fed on diets enriched with arginine and glycine. 1. Improved N retention after trauma. |
| PubMed:E1On the effect of 6-methyluracil on mice damaged by 2,4,6-triethylene-imino-1,3,5-triazine or by X-irradiation (author's transl). |
| PubMed:[Feeding rhythms and the diurnal rhythm of cell proliferation in pharmacologically induced liver growth (author's transl)]. |
| PubMed:Lithium orotate, carbonate and chloride: pharmacokinetics, polyuria in rats. |
| PubMed:Character of the stimulatory response of uridine kinase in rat livers to cycloheximide treatment. |
| PubMed:Reversible impairment of cerebral DNA synthesis in thiamine deficiency. |
| PubMed:Effect of narcotic drugs on ribonucleic acid and nucleotide metabolism in mouse brain. |
| PubMed:Nutrition and diseases of the blood: the megaloblastic anaemias. |
| PubMed:Nutrition and diseases of the liver and gallbladder. |
| PubMed:Neonatal undernutrition and RNA synthesis in developing rat brain. |
| PubMed:The determination of non-fat milk solids in milk bread from the orotic acid content. |
| PubMed:Effect of diet and tryptophan on hepatic polyribosomal disaggregation due to actinomycin D. |
| PubMed:[Formula diets in studies of purine balance]. |
| PubMed:Mechanisms of growth and atrophy of skeletal muscle. |
| PubMed:Orotic acid in food milk powders. |
| PubMed:Orotic acid in food milk powders. |
| PubMed:Nuclear synthesis of cytoplasmic ribonucleic acid in Amoeba proteus. |
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3D/inchi