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manganese chloride
manganese(II) chloride (1:2)

Supplier Sponsors

CAS Number: 7773-01-5Picture of molecule3D/inchi
Other(deleted CASRN):111283-62-6
ECHA EINECS - REACH Pre-Reg:231-869-6
FDA UNII: 6YB4901Y90
MDL:MFCD00011114
Molecular Weight:125.84204500
Formula:Cl2 Mn
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
1979 Manganous chloride View - review
DG SANTE Food Contact Materials:manganese chloride
FDA Mainterm (SATF):13446-34-9 ; MANGANESE CHLORIDE
FDA Regulation:
FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1446 Manganese chloride.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 652.00 °C. @ 760.00 mm Hg
Vapor Pressure:33900.00000 mmHg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 1.796e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Allan Chemical
Manganese Chloride 4H2O
American Elements
Manganese Chloride 99%
Odor: characteristic
Use: Manganese Chloride is an excellent water soluble crystalline Manganese source for uses compatible with chlorides. Hydrate or anhydrous forms may be purchased. Chloride compounds can conduct electricity when fused or dissolved in water. Chloride materials can be decomposed by electrolysis to chlorine gas and the metal. They are formed through various chlorination processes whereby at least one chlorine anion (Cl-) is covalently bonded to the relevant metal or cation. Ultra high purity and proprietary formulations can be prepared. The chloride ion controls fluid equilibrium and pH levels in metabolic systems. They can form either inorganic or organic compounds. Manganese Chloride is generally immediately available in most volumes. Ultra high purity and high purity compositions improve both optical quality and usefulness as scientific standards. Nanoscale (See also Nanotechnology Information and Quantum Dots) elemental powders and suspensions, as alternative high surface area forms, may be considered. We also produce Manganese Chloride Solution. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Manganese Chloride
BOC Sciences
For experimental / research use only.
Manganous chloride,anhydrous
Penta International
MANGANESE CHLORIDE ANHYDROUS USP
Sigma-Aldrich: Aldrich
For experimental / research use only.
Manganese(II) chloride powder and chunks, ≥99% trace metals basis
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 250 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 26(12), Pg. 8, 1961.

intravenous-rat LD50 92600 ug/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.

intraperitoneal-rat LD50 147 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Pharmacology. Vol. 23, Pg. 153, 1991.

oral-mouse LD50 1031 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(9), Pg. 15, 1971.

unreported-cat LDLo 4 mg/kg
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 102, Pg. 262, 1929.

intravenous-dog LD50 202 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

parenteral-dog LDLo 128 mg/kg
GASTROINTESTINAL: OTHER CHANGES CARDIAC: OTHER CHANGES VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 102, Pg. 262, 1929.

unreported-dog LDLo 600 ug/kg
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 102, Pg. 262, 1929.

oral-guinea pig LD50 916 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: TREMOR
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 36(9), Pg. 15, 1971.

unreported-guinea pig LDLo 60 mg/kg
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 102, Pg. 262, 1929.

intramuscular-mouse LD50 255 mg/kg
Russian Pharmacology and Toxicology Vol. 38, Pg. 221, 1975.

intraperitoneal-mouse LD50 121 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 244, Pg. 17, 1962.

intravenous-mouse LD50 38 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Acta Radiologica. Vol. 38, Pg. 770, 1997.

intravenous-rabbit LDLo 64800 ug/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

parenteral-rabbit LDLo 41 mg/kg
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION GASTROINTESTINAL: OTHER CHANGES CARDIAC: OTHER CHANGES
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 102, Pg. 262, 1929.

unreported-rabbit LDLo 6500 ug/kg
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 102, Pg. 262, 1929.

intramuscular-rat LD50 700 mg/kg
Russian Pharmacology and Toxicology Vol. 38, Pg. 221, 1975.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 180 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

subcutaneous-mouse LDLo 210 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

subcutaneous-rabbit LDLo 180 mg/kg
Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for manganese chloride usage levels up to:
 not for fragrance use.
 
Recommendation for manganese chloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of manganese compounds (E5) as feed additives for all animal species: manganous carbonate; manganous chloride, tetrahydrate; manganous oxide; manganous sulphate, monohydrate; manganese chelate of amino acids, hydrate; manganese chelate of glycine, hydrate, based on a dossier submitted by FEFANA asbl
View page or View pdf

EPI System: View
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AIDS Citations:Search
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EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):7773-01-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24480
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
dichloromanganese
Chemidplus:0007773015
RTECS:OO9625000 for cas# 7773-01-5
 
References:
 dichloromanganese
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7773-01-5
Pubchem (cid):24480
Pubchem (sid):134990295
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB013413
Export Tariff Code:2827.39.5000
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades: chemically pure; anhydrous •manganese chloride: 43% mn, water soluble, flakes.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 dichloromanganese
 manganese chloride anhydrous
 manganese chloride anhydrous USP
 manganese dichloride
 manganese(2+) dichloride
 manganese(II) chloride
 manganese(II) chloride (1:2)
 manganese(II) dichloride
 manganesechloride
 manganous chloride
 manganous dichloride
 

Articles:

PubMed:Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions.
PubMed:Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese.
PubMed:Effects of oxidative stress on apoptosis in manganese-induced testicular toxicity in cocks.
PubMed:Molecular mechanisms of Mn induced neurotoxicity: RONS generation, genotoxicity, and DNA-damage response.
PubMed:Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity.
PubMed:Manganese-induced effects on testicular trace element levels and crucial hormonal parameters of Hyline cocks.
PubMed:Manganese alters rat brain amino acids levels.
PubMed:The inhibitory effect of manganese on acetylcholinesterase activity enhances oxidative stress and neuroinflammation in the rat brain.
PubMed:Effect of manganese chloride on the neurochemical profile of the rat hypothalamus.
PubMed:Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice.
PubMed:Carcass maturity and dicationic salts affect preblended, low-fat, low-sodium restructured beef.
PubMed:Mapping of functional brain activity in freely behaving rats during voluntary running using manganese-enhanced MRI: implication for longitudinal studies.
PubMed:Morphological changes and manganese content in the brains of rat pups subjected to subchronic poisoning with manganese chloride.
PubMed:[Morphological changes and manganese level in the brain of rat pups subjected to subchronic manganese chloride intoxication].
PubMed:Error-prone rolling circle amplification: the simplest random mutagenesis protocol.
PubMed:Manganese-induced apoptosis in hepatocytes after partial hepatectomy.
PubMed:Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity.
PubMed:The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity.
PubMed:Maternal and developmental toxicity of manganese in the mouse.
PubMed:Subcellular and gel chromatographic distribution of manganese in the mouse brain: relation to the chemical form of chronically-ingested manganese.
 
Notes:
Used as a food additive [EAFUS] Nutrient supplement
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