acetyl salicylic acid
2-acetyloxybenzoic acid

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  BOC Sciences

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  50-78-2 Aspirin
  A salicylate and irreversible COX1 and COX2 inhibitor

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  ECSA Chemicals

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  MP-021998 ACETYLSALICYLIC ACID PH. EUR.

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  Glentham Life Sciences Ltd

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  GL2912 Acetylsalicylic acid
  GL0865 Acetylsalicylic acid, USP grade

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  For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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  01-10400 ACETYL SALICYLIC ACID

Name: 2-acetyloxybenzoic acid CAS Number: 50-78-2 3D/inchi ECHA EINECS - REACH Pre-Reg: 200-064-1 FDA UNII: R16CO5Y76E Nikkaji Web: J2.300K Beilstein Number: 779271 MDL: MFCD00002430 XlogP3: 1.20 (est) Molecular Weight: 180.15956000 Formula: C9 H8 O4 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:pharmaceuticals / chemical synthisis   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Appearance: white powder (est) Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 135.00 °C. @ 760.00 mm Hg Boiling Point: 321.39 °C. @ 760.00 mm Hg (est) Vapor Pressure: 0.000025 mmHg @ 25.00 °C. Flash Point: 268.00 °F. TCC ( 131.20 °C. ) (est) logP (o/w): 1.190 Soluble in:   water, 5295 mg/L @ 25 °C (est)   water, 4600 mg/L @ 25 °C (exp)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: Alfa Biotechnology For experimental / research use only. Acetylsalicylic acid 98% BOC Sciences For experimental / research use only. Aspirin Odor: characteristic Use: A salicylate and irreversible COX1 and COX2 inhibitor ECSA Chemicals ACETYLSALICYLIC ACID PH. EUR. ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY Glentham Life Sciences Acetylsalicylic acid, USP grade Glentham Life Sciences Acetylsalicylic acid Penta International ACETYL SALICYLIC ACID Sigma-Aldrich: Sigma For experimental / research use only. Acetylsalicylic acid ≥99.0%, crystalline sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: oral-child LDLo 104 mg/kg LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA BLOOD: HEMORRHAGE GASTROINTESTINAL: NAUSEA OR VOMITING Lancet. Vol. 2, Pg. 809, 1952. oral-child TDLo 10 mg/kg/1D-I LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED Clinical Toxicology. Vol. 18, Pg. 247, 1981. oral-child TDLo 39 mg/kg/13D-I LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" American Journal of Diseases of Children. Vol. 139, Pg. 453, 1985. intravenous-dog LD50 681 mg/kg BEHAVIORAL: ANALGESIA Archives Internationales de Pharmacodynamie et de Therapie. Vol. 149, Pg. 571, 1964. oral-dog LD50 700 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 719, 1971. oral-guinea pig LD50 1075 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. oral-hamster LD50 3500 mg/kg Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984. oral-human TDLo 480 mg/kg/7D-I BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 281, 1975. oral-human TDLo 669 mg/kg/11D LIVER: LIVER FUNCTION TESTS IMPAIRED American Journal of Hospital Pharmacy. Vol. 35, Pg. 330, 1978. oral-human TDLo 1050 mg/kg/14D VASCULAR: OTHER CHANGES Clinical Pharmacology and Therapeutics Vol. 67, Pg. 530, 2000. oral-human TDLo 2880 mg/kg/8W SENSE ORGANS AND SPECIAL SENSES: TINNITUS: EAR GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 631, 1983. oral-mammal (species unspecified) LD50 1750 mg/kg Indian Journal of Medical Research. Vol. 81, Pg. 621, 1985. unreported-man LDLo 294 mg/kg "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. oral-man TDLo 857 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA Human Toxicology. Vol. 7, Pg. 161, 1988. oral-man TDLo 1625 mg/kg BEHAVIORAL: COMA Clinical Pediatrics Vol. 24, Pg. 678, 1985. oral-man TDLo 13036 mg/kg/5Y SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" GASTROINTESTINAL: OTHER CHANGES MUSCULOSKELETAL: JOINTS Annals of Internal Medicine. Vol. 126, Pg. 665, 1997. intraperitoneal-mouse LD50 167 mg/kg United States Patent Document. Vol. #4376771 oral-mouse LD50 250 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. unreported-mouse LD50 1350 mg/kg United States Patent Document. Vol. #5240918 oral-rabbit LD50 1010 mg/kg BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(3), Pg. 43, 1980. intraperitoneal-rat LD50 340 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 62, Pg. 11, 1966. oral-rat LD50 200 mg/kg "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 67, 1969. Dermal Toxicity: subcutaneous-mouse LD50 1020 mg/kg Chemical and Pharmaceutical Bulletin. Vol. 28, Pg. 1237, 1980. Inhalation Toxicity: Not determined   Safety in Use Information: Category: pharmaceuticals / chemical synthisis Recommendation for acetyl salicylic acid usage levels up to:   not for fragrance use.   Recommendation for acetyl salicylic acid flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search NIOSH International Chemical Safety Cards:search NIOSH Pocket Guide:search Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search Carcinogenic Potency Database:Search EPA GENetic TOXicology:Search EPA Substance Registry Services (TSCA):50-78-2 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :2244 National Institute of Allergy and Infectious Diseases:Data WGK Germany:1 2-acetyloxybenzoic acid Chemidplus:0000050782 EPA/NOAA CAMEO:hazardous materials RTECS:50-78-2   References:   2-acetyloxybenzoic acid NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 50-78-2 Pubchem (cid): 2244 Pubchem (sid): 134971785   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View Golm Metabolome Database: Search KEGG (GenomeNet): C01405 HMDB (The Human Metabolome Database): HMDB01879 FooDB: FDB000894 Export Tariff Code: 2918.22.1000 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View Formulations/Preparations: aspirin formulations: aspirin formulations: preparations dose (mg) product manufacturer pieces, chewing gum aspergum heritage, schering plough tablets aspirin adult low strength geri-care,mango-humphries aspirin low dose basic viatamins norwich aspirin chattem 325 with buffers magnaprin, improved rugby 325 with buffers magnaprin arthritis strength rugby norwich aspirin maximum strength chattem norwich aspirin maximum strength chattem tablets, chewable bayer children's chewable aspirin bayer aspirin childrens amerisourcebergen, cardinal health, chain drug marketing, eckerd, ivax, major, pdk, prime marketing, qualitest, rugby, url aspirin for children geri-care st. joseph aspirin low strength chewable mcneil tablets, delayed-release (enteric-coated) aspirin adult low strength amerisourcebergen aspirin adult low strength aspirin enteric coated advance aspirin low dose qualitest aspirin regimen aspirin regimen low strength cardinal health bayer aspirin regimen adult low strength bayer ecotrin adult low strength (with propylene glycol) glaxosmithkline ecotrin adult low strength (with propylene glycol) glaxosmithkline st. joseph adult low strength enteric coated tablets mcneil 81 with buffers ascriptin enteric regular strength novartis halfprin kramer aspirin for arthritis cardinal health bayer aspirin regimen regular strength caplets (with propylene glycol bayer ecotrin regular strength (with propylene glycol) glaxosmithkline genacote 325 with buffers ascriptin enteric regular strength novartis aspirin extra strength medicine shoppe aspirin maximum strength chain drug marketing ecotrin maximum strength (with propylene glycol) glaxosmithkline aspirin delayed release tablets time-cap, united research easprin harvest tablets, extended-release zorprin tablets, film-coated 81 with buffers women's aspirin plus calcium caplets (with calcium carbonate and crospovidone) bayer aspirin lite coated amerisourcebergen aspirin microthin coating cardinal health bayer aspirin caplets bayer genuine bayer aspirin tablets bayer 325 with buffers ascriptin regular strength novartis 325 with buffers ascriptin arthritis pain caplets novartis 325 with buffers bufferin tablets (with povidone and propylene glycol), novartis consumer health bayer aspirin extra strength caplets (with propylene glycol) bayer bayer aspirin extra strength gelcaplets (with parabens) bayer bayer aspirin extra strength tablets bayer 500 with buffers ascriptin maximum strength caplets novartis 500 with buffers bayer aspirin plus buffered extra strength caplets (with calcium carbonate and propylene glycol) bayer 500 with buffers bufferin arthritis strength caplets (with povidone and propylene glycol) bristol-myers 500 with buffers bufferin extra strength (with povidone and propylene glycol) novartis consumer health tablets, for solution alka-seltzer effervescent pain reliever and antacid (with citric acid 1 g and sodium bicarbonate 1.916 g) bayer alka-seltzer lemon-lime effervescent pain reliever and antacid (with aspartame citric acid 1 g and sodium bicarbonate 1.7 g) bayer alka-seltzer extra strength effervescent pain reliever and antacid (with citric acid 1 g and sodium bicarbonate 1.985 g) bayer rectal suppositories aspirin suppositories consolidated midland aspirin suppositories consolidated midland aspirin suppositories consolidated midland aspirin suppositories consolidated midland, paddock aspirin suppositories consolidated midland, paddock   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   glycyrrhiza glabra var. typica root Search Trop Picture   Synonyms:   acesal   acesan   acetard 2- acetoxybenzenecarboxylic acid 2- acetoxybenzoic acid ortho- acetyl salicylic acid   acetyl salicylic acid USP 2-( acetyloxy)benzoic acid o-( acetyloxy)benzoic acid 2- acetyloxybenzoic acid o- acetylsalicylic acid ortho- acetylsalicylic acid   acimetten   asagran   ascriptin   aspirdrops   aspirin   aspirin 20-60 mesh USP   aspirin 40-80 mesh USP   aspirin USP   aspropharm   benaspir   benzoic acid, 2-(acetyloxy)-   cardioaspirina   claradin   clariprin   decaten   doril   easprin   globentyl   kapsazal   melhoral   micristin   miniasal   pharmacin   polopiryna   premaspin   rhodine NC RP   salcetogen   salospir   solprin   tasprin   toldex   triaminicin   Articles: Info:Aspirin

Notes: the prototypical analgesic used in the treatment of mild to moderate pain. it has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (from martindale, the extra pharmacopoeia, 30th ed, p5). Constit. of Glycyrrhiza glabra var. typica (licorice) roots