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flumequine
6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-quinolizine-2-carboxylic acid

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Name:9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
CAS Number: 42835-25-6Picture of molecule3D/inchi
Other(deleted CASRN):143984-63-8
ECHA EINECS - REACH Pre-Reg:255-962-6
FDA UNII: UVG8VSP2SJ
Nikkaji Web:J16.025C
Beilstein Number:0490724
MDL:MFCD00079298
XlogP3-AA:2.90 (est)
Molecular Weight:261.25264320
Formula:C14 H12 F N O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:herbicides / pesticides
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 2186 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Flumequine >98%
Odor: characteristic
Use: Flumequine is a synthetic chemotherapeutic antibiotic, inhibiting topoisomerase II with IC50 of 15 mM.It is a first-generation fluoroquinolone antibacterial that has been removed from clinical use and is no longer being marketed.
Glentham Life Sciences
Flumequine
Santa Cruz Biotechnology
For experimental / research use only.
Flumequine
Sigma-Aldrich: Sigma
For experimental / research use only.
Flumequine
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
herbicides / pesticides
Recommendation for flumequine usage levels up to:
 not for fragrance use.
 
Recommendation for flumequine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Setting of maximum residue levels for amitraz, coumaphos, flumequine, oxytetracycline, permethrin and streptomycin in certain products of animal origin
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3374
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
Chemidplus:0042835256
 
References:
 9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3374
Pubchem (sid):135002281
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D02302
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1H,5H-benzo(ij)quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-5-methyl-1-oxo-
6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-quinolizine-2-carboxylic acid
9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
9-fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
 

Articles:

PubMed:Antimicrobial susceptibility of Riemerella anatipestifer strains isolated from geese and ducks in Hungary.
PubMed:Antibiotic use in heavy pigs: Comparison between urine and muscle samples from food chain animals analysed by HPLC-MS/MS.
PubMed:Aeromonas Diversity and Antimicrobial Susceptibility in Freshwater-An Attempt to Set Generic Epidemiological Cut-Off Values.
PubMed:Phylogenetic analysis of Escherichia coli isolated from broilers with colibacillosis based on gyrA gene sequences.
PubMed:Analysis of flumequine enantiomers in rat plasma by UFLC-ESI-MS/MS.
PubMed:Provisional epidemiological cutoff values for standard broth microdilution susceptibility testing of Flavobacterium columnare.
PubMed:Validation of a Chiral Liquid Chromatographic Method for the Degradation Behavior of Flumequine Enantiomers in Mariculture Pond Water.
PubMed:Effect of various storage conditions on the stability of quinolones in raw milk.
PubMed:Use of micellar liquid chromatography to analyze oxolinic acid, flumequine, marbofloxacin and enrofloxacin in honey and validation according to the 2002/657/EC decision.
PubMed:[Multi-residue determination of veterinary drugs in cheese by QuEChERS and liquid chromatography-tandem mass spectrometry].
PubMed:Determination of selected veterinary antimicrobials in poultry excreta by UHPLC-MS/MS, for application in Salmonella control programs.
PubMed:Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.
PubMed:Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia.
PubMed:Antimicrobial resistance of Campylobacter jejuni and Campylobacter coli from poultry in Italy.
PubMed:Chemiluminescence competitive indirect enzyme immunoassay for 20 fluoroquinolone residues in fish and shrimp based on a single-chain variable fragment.
PubMed:Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver.
PubMed:Direct determination of danofloxacin and flumequine in milk by use of fluorescence spectrometry in combination with partial least-squares calibration.
PubMed:Degradation of flumequine by the Fenton and photo-Fenton processes: evaluation of residual antimicrobial activity.
PubMed:Quality control ranges for testing broth microdilution susceptibility of Flavobacterium columnare and F. psychrophilum to nine antimicrobials.
PubMed:Laser diode thermal desorption mass spectrometry for the analysis of quinolone antibiotic residues in aquacultured seafood.
PubMed:HPLC confirmatory method development for the determination of seven quinolones in salmon tissue (Salmo salar L.) validated according to the European Union Decision 2002/657/EC.
PubMed:Analysis of quinolone antibiotics in eggs: preparation and characterization of a raw material for method validation and quality control.
PubMed:Development of an improved method for trace analysis of quinolones in eggs of laying hens and wildlife species using molecularly imprinted polymers.
PubMed:Determination of (fluoro)quinolones in eggs by liquid chromatography with fluorescence detection and confirmation by liquid chromatography-tandem mass spectrometry.
PubMed:Determination of quinolones of veterinary use in bee products by ultra-high performance liquid chromatography-tandem mass spectrometry using a QuEChERS extraction procedure.
PubMed:Multiresidue determination of veterinary drugs in aquaculture fish samples by ultra high performance liquid chromatography coupled to tandem mass spectrometry.
PubMed:Impact of antibiotic treatments on the expression of the R plasmid tra genes and on the host innate immune activity during pRAS1 bearing Aeromonas hydrophila infection in zebrafish (Danio rerio).
PubMed:Development and validation of a multiclass method for the determination of veterinary drug residues in chicken by ultra high performance liquid chromatography-tandem mass spectrometry.
PubMed:DNA gyrase and topoisomerase IV mutations in quinolone-resistant Flavobacterium psychrophilum isolated from diseased salmonids in Norway.
PubMed:A sensitive chromatographic strip test for the rapid detection of enrofloxacin in chicken muscle.
PubMed:Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction.
PubMed:[Preparation of natural matrix standard sample of minced eel for quality control of flumequine residue].
PubMed:Rapid screening method for quinolone residues in livestock and fishery products using immobilised metal chelate affinity chromatographic clean-up and liquid chromatography-fluorescence detection.
PubMed:Determination of quinolone residues in infant and young children powdered milk combining solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry.
PubMed:Development of a quantitative multiclass/multiresidue method for 21 veterinary drugs in shrimp.
PubMed:Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers.
PubMed:Are antibiotic screening approaches sufficiently adequate? A proficiency test.
PubMed:Quantitation of fluoroquinolones in honey using tandem mass spectrometry (LC-MS/MS): nested validation with two mass spectrometers.
PubMed:Quinolones control in milk and eggs samples by liquid chromatography using a surfactant-mediated mobile phase.
PubMed:Depletion of veterinary drugs used in aquaculture after administration in feed to gilthead seabream (Sparus aurata).
PubMed:Simultaneous determination of quinolones in fish by liquid chromatography coupled with fluorescence detection: comparison of sub-2 microm particles and conventional C18 columns.
PubMed:Environmental and human health risk assessment of organic micro-pollutants occurring in a Spanish marine fish farm.
PubMed:Determination of quinolone residues in tilapias (Orechromis niloticus) by HPLC-FLD and LC-MS/MS QToF.
PubMed:Validation of an optical surface plasmon resonance biosensor assay for screening (fluoro)quinolones in egg, fish and poultry.
PubMed:Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry.
PubMed:Evaluation of quinolones for use in detection of determinants of acquired quinolone resistance, including the new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6')Ib-cr, in Escherichia coli and Salmonella enterica and determinations of wild-type distributions.
PubMed:Quantitation and identity confirmation of residues of quinolones in tilapia fillets by LC-ESI-MS-MS QToF.
PubMed:Assessment of antimicrobial usage and residues in commercial chicken eggs from smallholder poultry keepers in Morogoro municipality, Tanzania.
PubMed:[Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry].
PubMed:Simultaneous determination of (fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography-tandem mass spectrometry.
PubMed:Developing and optimizing an immunoaffinity cleanup technique for determination of quinolones from chicken muscle.
PubMed:Selective sample preparation for the analysis of (fluoro)quinolones in baby food: molecularly imprinted polymers versus anion-exchange resins.
PubMed:Development of an optical surface plasmon resonance biosensor assay for (fluoro)quinolones in egg, fish, and poultry meat.
PubMed:Development of an immunochromatography strip for the rapid detection of 12 fluoroquinolones in chicken muscle and liver.
PubMed:In-line solid-phase extraction preconcentration in capillary electrophoresis-tandem mass spectrometry for the multiresidue detection of quinolones in meat by pressurized liquid extraction.
PubMed:[Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry].
PubMed:Oral bioavailability, tissue distribution and depletion of flumequine in the food producing animal, chicken for fattening.
PubMed:Simultaneous determination of different classes of antibiotics in fish and livestock by CE-MS.
PubMed:Development and validation of an HPLC confirmatory method for residue analysis of ten quinolones in tissues of various food-producing animals, according to the European Union Decision 2002/657/EC.
PubMed:Chromatographic determination of flumequine in food samples by post-column derivatisation with terbium(III).
PubMed:Determination of quinolone residues in shrimp using liquid chromatography with fluorescence detection and residue confirmation by mass spectrometry.
PubMed:Improved microbial screening assay for the detection of quinolone residues in poultry and eggs.
PubMed:Development of a monoclonal antibody-based broad-specificity ELISA for fluoroquinolone antibiotics in foods and molecular modeling studies of cross-reactive compounds.
PubMed:Multiresidue determination of quinolone and fluoroquinolone antibiotics in fish and shrimp by liquid chromatography/tandem mass spectrometry.
PubMed:Simultaneous determination of trace levels of 10 quinolones in swine, chicken, and shrimp muscle tissues using HPLC with programmable fluorescence detection.
PubMed:Biosensor immunoassay for flumequine in broiler serum and muscle.
PubMed:Stability of frozen stock solutions of beta-lactam antibiotics, cephalosporins, tetracyclines and quinolones used in antibiotic residue screening and antibiotic susceptibility testing.
PubMed:Dual biosensor immunoassay-directed identification of fluoroquinolones in chicken muscle by liquid chromatography electrospray time-of-flight mass spectrometry.
PubMed:Evaluation of certain veterinary drug residues in food. Sixty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed:Microbiological detection of 10 quinolone antibiotic residues and its application to artificially contaminated poultry samples.
PubMed:Determination of fluoroquinolones in milk samples by postcolumn derivatization liquid chromatography with luminescence detection.
PubMed:Biotransformation of flumequine by the fungus Cunninghamella elegans.
PubMed:Multiresidue method for the determination of quinolone antibiotics in bovine raw milk by capillary electrophoresis-tandem mass spectrometry.
PubMed:Confirmatory and quantitative analysis using experimental design for the extraction and liquid chromatography-UV, liquid chromatography-mass spectrometry and liquid chromatography-mass spectrometry/mass spectrometry determination of quinolones in turkey muscle.
PubMed:Simultaneous determination of (fluoro)quinolone antibiotics in kidney, marine products, eggs, and muscle by enzyme-linked immunosorbent assay (ELISA).
PubMed:Evaluation of the Premi Test and comparison with the One-Plate Test for the detection of antimicrobials in kidney.
PubMed:Flumequine in the goat: pharmacokinetics after intravenous and intramuscular administration.
PubMed:Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: single laboratory validation study.
PubMed:Standardization of a broth microdilution susceptibility testing method to determine minimum inhibitory concentrations of aquatic bacteria.
PubMed:Introduction of the HPLC method for the determination of quinolone residues in various muscle tissues.
PubMed:Evaluation of certain veterinary drug residues in food. Sixty-second report of the Joint FAO/WHO Expert Committee on food additives.
PubMed:Development of an indirect competitive ELISA for flumequine residues in raw milk using chicken egg yolk antibodies.
PubMed:Evaluation of certain veterinary drug residues in food.
PubMed:Susceptibility of Listeria monocytogenes isolated from food in Italy to antibiotics.
PubMed:Simple and sensitive determination of five quinolones in food by liquid chromatography with fluorescence detection.
PubMed:Quantitative LC/MS-MS determination of sulfonamides and some other antibiotics in honey.
PubMed:Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water.
PubMed:Determination of residues of oxolinic acid and flumequine in freeze-dried salmon muscle and skin by HPLC with fluorescence detection.
PubMed:Disposition of 14C-flumequine in eel Anguilla anguilla, turbot Scophthalmus maximus and halibut Hippoglossus hippoglossus after oral and intravenous administration.
PubMed:Antimicrobial susceptibility of potentially pathogenic halophilic vibrios isolated from seafood.
PubMed:Evaluation of certain veterinary drug residues in food.
PubMed:Inhibition tests for detection and presumptive identification of tetracyclines, beta-lactam antibiotics and quinolones in poultry meat.
PubMed:Comparison of extraction techniques for the recovery of veterinary drug residues from animal tissues.
PubMed:Single-dose pharmacokinetics of flumequine in the eel (Anguilla anguilla) after intravascular, oral and bath administration.
PubMed:Single-dose pharmacokinetics of flumequine in cod (Gadus morhua) and goldsinny wrasse (Ctenolabrus rupestris).
PubMed:[Preliminary results of antibiotic resistance monitoring in the Netherlands].
PubMed:Salmonella infections in finishing pigs in The Netherlands: bacteriological herd prevalence, serogroup and antibiotic resistance of isolates and risk factors for infection.
PubMed:Extension of multi-residue methodology to include the determination of quinolones in food.
PubMed:Single-dose pharmacokinetics of flumequine in halibut (Hippoglossus hippoglossus) and turbot (Scophthalmus maximus).
PubMed:Determination of flumequine in channel catfish by liquid chromatography with fluorescence detection.
PubMed:Enumeration and characterization of bacteria in mineral water by improved direct viable count method.
PubMed:Excretion of flumequine in free-swimming Atlantic salmon (Salmo salar), determined by cannulation of the dorsal aorta, gall bladder and urethra.
PubMed:Evaluation of certain veterinary drug residues in food. Forty-eighth report of the Joint FAO/WHO Expert Committee on Food Additives.
PubMed:Liquid chromatographic determination of flumequine, nalidixic acid, oxolinic acid, and piromidic acid residues in catfish (Ictalurus punctatus).
PubMed:Determination of residues of flumequine and 7-hydroxyflumequine in edible sheep tissues by liquid chromatography with fluorimetric and ultraviolet detection.
PubMed:Evaluation of the dorsal aorta cannulation technique for pharmacokinetic studies in Atlantic salmon (Salmo salar) in sea water.
PubMed:Determination and confirmation of identities of flumequine and nalidixic, oxolinic, and piromidic acids in salmon and shrimp.
PubMed:Antibiotic susceptibility of campylobacter isolates from sewage and poultry abattoir drain water.
PubMed:Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin, in Atlantic salmon (Salmo salar) held in seawater at 10 degrees C.
PubMed:Establishment of a microbiologically acceptable daily intake of antimicrobial drug residues.
PubMed:Bioavailability of flumequine after semisimultaneous administration to veal calves.
PubMed:Effect of cooking on residues of the quinolones oxolinic acid and flumequine in fish.
PubMed:Reservoir of quinolone residues in fish.
 
Notes:
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