| Flavor Demo Formulas |
| Name: | [2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate |
| CAS Number: | 1401-55-4 |  3D/inchi
|
| Other(deleted CASRN): | 61790-06-5 |
| ECHA EINECS - REACH Pre-Reg: | 215-753-2 |
| FDA UNII: | 28F9E0DJY6 |
| Nikkaji Web: | J1.666.475H |
| Beilstein Number: | 8186396 |
| MDL: | MFCD00066397 |
| CoE Number: | 746 |
| XlogP3-AA: | 6.20 (est) |
| Molecular Weight: | 1701.21364000 |
| Formula: | C76 H52 O46 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:flavoring agents and adjuvants, curing and pickling agents, flavor enhancers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | tan to brown powder (est) |
| Assay: | 98.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 218.00 °C. @ 760.00 mm Hg
|
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
|
| logP (o/w): | 13.327 (est) |
| Soluble in: |
| | water, 512.4 mg/L @ 25 °C (est) | | | acetone | | | alcohol |
| Insoluble in: |
| | ether |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 5000 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 138, Pg. 65, 1928.
intravenous-mouse LD50 130 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intravenous-mouse LD50 50 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intraperitoneal-mouse LD50 360 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intraperitoneal-mouse LD50 320 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intraperitoneal-mouse LD50 150 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intraperitoneal-mouse LD50 120 mg/kg
Planta Medica. Vol. 52, Pg. 272, 1986.
intravenous-guinea pig LDLo 40 mg/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 571, 1969.
intramuscular-mouse LD50 120 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intramuscular-mouse LD50 350 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intramuscular-mouse LD50 > 1600 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
intravenous-mouse LDLo 10 mg/kg
SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 63, 1943.
oral-mouse LDLo 2000 mg/kg
SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 63, 1943.
oral-rabbit LD50 5000 mg/kg
LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
GASTROINTESTINAL: GASTRITIS
American Journal of Veterinary Research. Vol. 23, Pg. 1264, 1962.
oral-rat LD50 2260 mg/kg
GASTROINTESTINAL: OTHER CHANGES
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 571, 1969.
parenteral-rat LDLo 1400 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 565, 1976.
|
| Dermal Toxicity: |
subcutaneous-mouse LD50 140 mg/kg
Food and Cosmetics Toxicology. Vol. 14, Pg. 565, 1976.
subcutaneous-mouse LD50 140 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
subcutaneous-mouse LD50 > 1600 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 9, Pg. 98, 1957.
subcutaneous-mouse LDLo 75 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
SENSE ORGANS AND SPECIAL SENSES: HEMORRHAGE: EYE
Journal of Pharmacology and Experimental Therapeutics. Vol. 77, Pg. 63, 1943.
subcutaneous-rat LDLo 200 mg/kg
Wiener Klinische Wochenschrift. Vol. 62, Pg. 270, 1950.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | flavoring agents and adjuvants, curing and pickling agents, flavor enhancers |
| Recommendation for tannic acid usage levels up to: | | | not for fragrance use.
|
| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 40.00000 |
| beverages(nonalcoholic): | 1.10000 | 45.00000 |
| beverages(alcoholic): | 6.00000 | 1000.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 160.00000 |
| fruit ices: | - | 160.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | 0.20000 | 100.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf
|
Scientific Opinion on the safety and efficacy of tannic acid when used as feed flavouring for all animal species
View page or View pdf
|
Outcome of the consultation with Member States and EFSA on the basic substance application for Castanea and Schinopsis tannins for use in plant protection as bactericide, fungicide and nematicide
View page or View pdf
|
| EPI System: View |
| ClinicalTrials.gov:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA GENetic TOXicology:Search |
| EPA Substance Registry Services (TSCA):1401-55-4 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :16129878 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| [2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate |
| Chemidplus:0001401554 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:WW5075000 for cas# 1401-55-4 |
References:
| | [2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 1401-55-4 |
| Pubchem (cid): | 16129878 |
| Pubchem (sid): | 135262200 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acacia mollissima tannin | | | castanea sativa mill tannin | | | gallotannic acid | | D- | glucopyranose,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]benzoate] | | | glycerite | | sweet | gum | | [2,3- | ihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate | | | quebracho wood extract | | | quercus spp. | | | quercus spp. philippines | | | schinopsis lorentzii tannin | | | tannic acid 80% | | | tannic acid 90% | | | tannic acid food grade natural | | | tannic acid food grade synthetic | | | tannic acid natural | | | tannic acid USP | | | tannin from chestnut | | | tannin from mimosa | | | tannin from quebracho | | | tannin from sweet gum | | | tannins | | | tannins. gallic acid derivatives found in nutgalls, bark and other plant parts, especially oak bark |
Articles:
| PubMed:Flavor characteristics of seven grades of black tea produced in Turkey. |
| PubMed:Food color, flavor, and conditioned avoidance among red-winged blackbirds. |
| PubMed:Tannins and human health: a review. |
| PubMed:Taste and olfactory processing in the brain and its relation to the control of eating. |
| PubMed:A novel calcium supplement prepared by phytoferritin nanocages protects against absorption inhibitors through a unique pathway. |
| PubMed:Tannic acid functionalized N-doped graphene modified glassy carbon electrode for the determination of bisphenol A in food package. |
| PubMed:NOVEL TRENDS FOR USE OF MICROBIAL TANNASES. |
| PubMed:Carotenoids, but not vitamin A, improve iron uptake and ferritin synthesis by Caco-2 cells from ferrous fumarate and NaFe-EDTA. |
| PubMed:Analysis of interaction of phenolic compounds with the cholecystokinin signaling pathway to explain effects on reducing food intake. |
| PubMed:Binary solvent extraction system and extraction time effects on phenolic antioxidants from kenaf seeds (Hibiscus cannabinus L.) extracted by a pulsed ultrasonic-assisted extraction. |
| PubMed:Response of multiple generations of semilooper, Achaea janata feeding on castor to elevated CO2. |
| PubMed:Effect of calcium, tannic acid, phytic acid and pectin over iron uptake in an in vitro Caco-2 cell model. |
| PubMed:A comparative study of the antioxidant scavenging activity of green tea, black tea and coffee extracts: a kinetic approach. |
| PubMed:Some factors affecting tannase production by Aspergillus niger Van Tieghem. |
| PubMed:Tannic Acid influence on lead and cadmium accumulation in the hearts and lungs of rats. |
| PubMed:Production of tannase under solid-state fermentation and its application in detannification of guava juice. |
| PubMed:Devices for the endoscopic treatment of hemorrhoids. |
| PubMed:Angiotensin-converting enzyme inhibitory effects by plant phenolic compounds: a study of structure activity relationships. |
| PubMed:Acorn selection by the wood mouse Apodemus sylvaticus: a semi-controlled experiment in a Mediterranean environment. |
| PubMed:Dietary antioxidant activities in different germplasms of Mucuna. |
| PubMed:Compositional, nutritional, and functional characteristics of instant teas produced from low- and high-quality black teas. |
| PubMed:Effects of elevated atmospheric CO2 on competition between the mosquitoes Aedes albopictus and Ae. triseriatus via changes in litter quality and production. |
| PubMed:Crystal structure of tannase from Lactobacillus plantarum. |
| PubMed:Microencapsulation of tannic acid for oral administration to inhibit carbohydrate digestion in the gastrointestinal tract. |
| PubMed:Non-covalent crosslinkers for electrospun chitosan fibers. |
| PubMed:Protective effect of tannic acid on the brain of adult rats exposed to cadmium and lead. |
| PubMed:Study of the adsorption of Cr(VI) by tannic acid immobilised powdered activated carbon from micro-polluted water in the presence of dissolved humic acid. |
| PubMed:Impact of elevated CO₂ on tobacco caterpillar, Spodoptera litura on peanut, Arachis hypogea. |
| PubMed:Development of a portable taste sensor with a lipid/polymer membrane. |
| PubMed:Combination of quercetin and tannic acid in inhibiting 26S proteasome affects S5a and 20S expression, and accumulation of ubiquitin resulted in apoptosis in cancer chemoprevention. |
| PubMed:Retardation of myoglobin and haemoglobin-mediated lipid oxidation in washed bighead carp by phenolic compounds. |
| PubMed:Evidence for an enhancing effect of alginate on iron availability in Caco-2 cells. |
| PubMed:Evaluating cell specific cytotoxicity of differentially charged silver nanoparticles. |
| PubMed:Measurements of thermodynamic and optical properties of selected aqueous organic and organic-inorganic mixtures of atmospheric relevance. |
| PubMed:Inactivation of human norovirus surrogates by benzalkonium chloride, potassium peroxymonosulfate, tannic acid, and gallic acid. |
| PubMed:Cholorpheniramine tannate complexes: physicochemical, chemometric, and taste masking evaluation. |
| PubMed:Rapid assessment of endpoint antioxidant capacity of red wines through microchemical methods using a kinetic matching approach. |
| PubMed:Characterization of taste-active compounds of various cherry wines and their correlation with sensory attributes. |
| PubMed:Tolerance to dietary phenolics and diet breadth in three seed-eating birds: implications for Graminivory. |
| PubMed:Influence of gallic acid and tannic acid on the mechanical and barrier properties of wheat gluten films. |
| PubMed:Flavor characteristics of seven grades of black tea produced in Turkey. |
| PubMed:Total phenolic content, consumer acceptance, and instrumental analysis of bread made with grape seed flour. |
| PubMed:Removal of Cr(VI) from low-temperature micro-polluted surface water by tannic acid immobilized powdered activated carbon. |
| PubMed:Phytochemical Composition, Antioxidant and Xanthine Oxidase Inhibitory Activities of Amaranthus cruentus L. and Amaranthus hybridus L. Extracts. |
| PubMed:Interspecific differences in tannin intakes of forest-dwelling rodents in the wild revealed by a new method using fecal proline content. |
| PubMed:Heat treatment to modify the structural and physical properties of chitosan-based films. |
| PubMed:Reutilization of mango byproducts: study of the effect of extraction solvent and temperature on their antioxidant properties. |
| PubMed:FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. |
| PubMed:Characterization of a Basidiomycete fungus from stored sugar beet roots. |
| PubMed:Tannate complexes of antihistaminic drug: sustained release and taste masking approaches. |
| PubMed:Aversive effect of tannic acid on drinking behavior in mice of an inbred strain: potential animal model for assessing astringency. |
| PubMed:Optimization of tannase production by Aspergillus niger in solid-state packed-bed bioreactor. |
| PubMed:Catalytical Properties of Free and Immobilized Aspergillus niger Tannase. |
| PubMed:A new process for simultaneous production of tannase and phytase by Paecilomyces variotii in solid-state fermentation of orange pomace. |
| PubMed:Catalytic and thermodynamic properties of a tannase produced by Aspergillus niger GH1 grown on polyurethane foam. |
| PubMed:A tannic acid-based medical food, Cesinex(®), exhibits broad-spectrum antidiarrheal properties: a mechanistic and clinical study. |
| PubMed:Tannic acid is more effective than clofibrate for the elevation of hepatic β-oxidation and the inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and aortic lesion formation in apo E-deficient mice. |
| PubMed:Response of a Lactobacillus plantarum human isolate to tannic acid challenge assessed by proteomic analyses. |
| PubMed:Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells. |
| PubMed:Influence of combinations of promoter and inhibitor on the bioaccessibility of iron and zinc from food grains. |
| PubMed:Ascorbic acid degradation in a model apple juice system and in apple juice during ultraviolet processing and storage. |
| PubMed:Dietary ligands as determinants of iron-zinc interactions at the absorptive enterocyte. |
| PubMed:First identification of tannin-binding proteins in saliva of Papio hamadryas using MS/MS mass spectrometry. |
| PubMed:Differential properties of Aspergillus niger tannase produced under solid-state and submerged fermentations. |
| PubMed:Immobilization of Paecilomyces variotii tannase and properties of the immobilized enzyme. |
| PubMed:Isolation and characterization of a novel tannase from a metagenomic library. |
| PubMed:Individual astringency responsiveness affects the acceptance of phenol-rich foods. |
| PubMed:Propyl gallate synthesis using acidophilic tannase and simultaneous production of tannase and gallic acid by marine Aspergillus awamori BTMFW032. |
| PubMed:Damage to the intestinal epithelial barrier by antibiotic pretreatment of salmonella-infected rats is lessened by dietary calcium or tannic acid. |
| PubMed:Evaluation of certain food additives. Seventy-first report of the Joint FAO/WHO Expert Committee on Food Additives. |
| PubMed:Effects of tannic acid on gluten protein structure, dough properties and bread quality of Chinese wheat. |
| PubMed:Quantitative determination of interactions between tannic acid and a model protein using diffusion and precipitation assays on cellulose membranes. |
| PubMed:Antioxidant activity and hepatoprotective property of leaf extracts of Boerhaavia diffusa Linn against acetaminophen-induced liver damage in rats. |
| PubMed:Polyphenol-rich beverages enhance zinc uptake and metallothionein expression in Caco-2 cells. |
| PubMed:Identification of natural antimicrobial substances in red muscadine juice against Cronobacter sakazakii. |
| PubMed:Chemical modification of gelatin by a natural phenolic cross-linker, tannic acid. |
| PubMed:Hydrolysis of tannic acid catalyzed by immobilized-stabilized derivatives of Tannase from Lactobacillus plantarum. |
| PubMed:Antioxidant activity and chemical difference in fruit of different Actinidia sp. |
| PubMed:Screening of phenolic antioxidants for their inhibitory activity against foodborne Staphylococcus aureus strains. |
| PubMed:Enhanced antimicrobial activity of starch-based film impregnated with thermally processed tannic acid, a strong antioxidant. |
| PubMed:Iron absorption from brown rice/brown rice-based meal and milled rice/milled rice-based meal. |
| PubMed:Ogataea pignaliae sp. nov., the teleomorph of Candida pignaliae. |
| PubMed:Analysis of the polyphenols content in medicinal plants based on the reduction of Cu(II)/bicinchoninic complexes. |
| PubMed:Stimulatory role of grape pomace polyphenols on Lactobacillus acidophilus growth. |
| PubMed:The potential health benefits of legumes as a good source of dietary fibre. |
| PubMed:Characterization And Application Of Tannase Produced By Aspergillus Niger ITCC 6514.07 On Pomegranate Rind. |
| PubMed:Production and physicochemical properties of recombinant Lactobacillus plantarum tannase. |
| PubMed:Limitations of the tetramethylmurexide assay for investigating the Fe(II) chelation activity of phenolic compounds. |
| PubMed:Comparing soluble ferric pyrophosphate to common iron salts and chelates as sources of bioavailable iron in a Caco-2 cell culture model. |
| PubMed:Influence of dissolved organic matter and invertebrates on the function of microbial films in groundwater. |
| PubMed:Antibacterial activity of fresh and processed red muscadine juice and the role of their polar compounds on Escherichia coli O157:H7. |
| PubMed:Saliva characteristics and individual sensitivity to phenolic astringent stimuli. |
| PubMed:Inactivation of Enterobacter sakazakii by water-soluble muscadine seed extracts. |
| PubMed:Development of feeding selectivity and consistency in food choice over 5 years in fallow deer. |
| PubMed:Studies on Indian green leafy vegetables for their antioxidant activity. |
| PubMed:Effect of dietary ligands and food matrices on zinc uptake in Caco-2 cells: implications in assessing zinc bioavailability. |
| PubMed:Effects of ascorbic acid, phytic acid and tannic acid on iron bioavailability from reconstituted ferritin measured by an in vitro digestion-Caco-2 cell model. |
| PubMed:Antimicrobial effect of water-soluble muscadine seed extracts on Escherichia coli O157:H7. |
| PubMed:Very rapid quantification of malondialdehyde (MDA) in rat brain exposed to lead, aluminium and phenolic antioxidants by high-performance liquid chromatography-fluorescence detection. |
| PubMed:Dietary and nutritional biomarkers of lens degeneration, oxidative stress and micronutrient inadequacies in Indian cataract patients. |
| PubMed:Inhibition of Arcobacter butzleri, Arcobacter cryaerophilus, and Arcobacter skirrowii by plant oil aromatics. |
| PubMed:Effect of naturally occurring phenolic acids on the expression of glutathione S-transferase isozymes in the rat. |
| PubMed:Characterization of tannase activity in cell-free extracts of Lactobacillus plantarum CECT 748T. |
| PubMed:The influence of dietary tannin supplementation on digestive performance in captive black rhinoceros (Diceros bicornis). |
| PubMed:Safety tests and antinutrient analyses of noni (Morinda citrifolia L.) leaf. |
| PubMed:Assay-guided fractionation study of alpha-amylase inhibitors from Garcinia mangostana pericarp. |
| PubMed:The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. |
| PubMed:Cytotoxic effect of gallic acid on testicular cell lines with increasing H2O2 level in GC-1 spg cells. |
| PubMed:Food color, flavor, and conditioned avoidance among red-winged blackbirds. |
| PubMed:Abrogation of thioacetamide-induced biochemical events of hepatic tumor promotion stage by tannic acid in Wistar rats. |
| PubMed:Mycotoxins in edible tree nuts. |
| PubMed:Development of alcoholic and malolactic fermentations in highly acidic and phenolic apple musts. |
| PubMed:Lipid-lowering effect of hot water-soluble extracts of Saururus chinensis Bail on rats fed high fat diets. |
| PubMed:Interaction of different polyphenols with bovine serum albumin (BSA) and human salivary alpha-amylase (HSA) by fluorescence quenching. |
| PubMed:The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells. |
| PubMed:Tannic acid induces in vitro acantholysis of keratinocytes via IL-1alpha and TNF-alpha. |
| PubMed:Flow field-flow fractionation-inductively coupled optical emission spectrometric investigation of the size-based distribution of iron complexed to phytic and tannic acids in a food suspension: implications for iron availability. |
| PubMed:Effects of dietary factors on iron uptake from ferritin by Caco-2 cells. |
| PubMed:Profiling and characterization by LC-MSn of the galloylquinic acids of green tea, tara tannin, and tannic acid. |
| PubMed:Effect of tannic acid on Lactobacillus hilgardii analysed by a proteomic approach. |
| PubMed:Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. |
| PubMed:Hydrolyzable tannins with the hexahydroxydiphenoyl unit and the m-depsidic link: HPLC-DAD-MS identification and model synthesis. |
| PubMed:Antioxidant activity of indigenous edible mushrooms. |
| PubMed:Comparative analysis of influence of promoters and inhibitors on in vitro available iron using two methods. |
| PubMed:Statistical model for predicting non-heme iron bioavailability from vegetarian meals. |
| PubMed:Nutritional quality of leaves of some genotypes of mulberry (Morus alba). |
| PubMed:Tannase production by Paecilomyces variotii. |
| PubMed:Compartmentalization of oxidative stress and antioxidant defense in the larval gut of Spodoptera littoralis. |
| PubMed:Alteration of kafirin and kafirin film structure by heating with microwave energy and tannin complexation. |
| PubMed:Monitoring and estimation of the kinetics parameters in the binding process of tannic acid to bovine serum albumin with electrochemical quartz crystal impedance system. |
| PubMed:Preventive effect of tannic acid on 2-acetylaminofluorene induced antioxidant level, tumor promotion and hepatotoxicity: a chemopreventive study. |
| PubMed:Biodegradation of gallotannins and ellagitannins. |
| PubMed:Isolation and evaluation of tannin-degrading fungal strains from the Mexican desert. |
| PubMed:Production, properties and application to biocatalysis of a novel extracellular alkaline phenol oxidase from the thermophilic fungus Scytalidium thermophilum. |
| PubMed:Meat and ascorbic acid can promote Fe availability from Fe-phytate but not from Fe-tannic acid complexes. |
| PubMed:Haze formation in model beer systems. |
| PubMed:Plant phenolics behave as radical scavengers in the context of insect (Manduca sexta) hemolymph and midgut fluid. |
| PubMed:Determination of tannin in green tea infusion by flow-injection analysis based on quenching the fluorescence of 3-aminophthalate. |
| PubMed:The role of taste in food selection by African apes: implications for niche separation and overlap in tropical forests. |
| PubMed:Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts. |
| PubMed:Effects of dissolved organic carbon on phosphate retention on two calcareous soils. |
| PubMed:Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease. |
| PubMed:Effects of tannic acid and its related compounds on food mutagens or hydrogen peroxide-induced DNA strands breaks in human lymphocytes. |
| PubMed:Antioxidant defense of the midgut epithelium by the peritrophic envelope in caterpillars. |
| PubMed:Changes in midgut and brain proteins in Morimus funereus larvae depending on nutritive substrate. |
| PubMed:Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro. |
| PubMed:Inhibitory effects of polyphenols in leaves of Artemisia princeps PAMP on protein fragmentation by Cu(II)-H2O2 in vitro. |
| PubMed:Efficacy of animal anti-fertility compounds against sea lamprey (Petromyzon marinus) spermatozoa. |
| PubMed:Characterization of phenolic compounds in some Indian mango cultivars. |
| PubMed:New method for evaluating astringency in red wine. |
| PubMed:Captive roe deer (Capreolus capreolus) select for low amounts of tannic acid but not quebracho: fluctuation of preferences and potential benefits. |
| PubMed:Impact of dietary allelochemicals on gypsy moth (Lymantria dispar) caterpillars: importance of midgut alkalinity. |
| PubMed:Synthesis of antioxidant propyl gallate using tannase from Aspergillus niger van Teighem in nonaqueous media. |
| PubMed:Method for analysis of tannic acid and its metabolites in biological samples: application to tannic acid metabolism in the rat. |
| PubMed:Culture conditions dictate protease and tannase production in submerged and solid-state cultures of Aspergillus niger Aa-20. |
| PubMed:Relationships between threshold-based PROP sensitivity and food preferences of Tunisians. |
| PubMed:Turbidity as a measure of salivary protein reactions with astringent substances. |
| PubMed:Gut-based antioxidant enzymes in a polyphagous and a graminivorous grasshopper. |
| PubMed:Polyphenol-induced inhibition of the response of na(+)/glucose cotransporter expressed in Xenopus oocytes. |
| PubMed:Transaminase and alkaline phosphatase activity in the serum of burn patients treated with highly purified tannic acid. |
| PubMed:Melanoidins exert a weak antiradical activity in watery fluids. |
| PubMed:Deterioration of natural antioxidant species of vegetable edible oils during the domestic deep-frying and pan-frying of potatoes. |
| PubMed:Characterization of haze-active proteins in apple juice. |
| PubMed:Inhibition of iron uptake by phytic acid, tannic acid, and ZnCl2: studies using an in vitro digestion/Caco-2 cell model. |
| PubMed:The historical aspects of sunscreens. |
| PubMed:Effects of tannic acid on cecal volatile fatty acids and susceptibility to Salmonella typhimurium colonization in broiler chicks. |
| PubMed:Differential long-term effects of tannic acid on adenyl cyclase activity and lipolysis in rat adipocytes. |
| PubMed:Production of tannase by Aspergillus niger Aa-20 in submerged and solid-state fermentation: influence of glucose and tannic acid. |
| PubMed:Palatability of bird repellents to Rattus norvegicus. |
| PubMed:The effects of tannins on nutrient utilisation in the White Pekin duck. |
| PubMed:Gustatory responsiveness to food-associated sugars and acids in pigtail macaques, Macaca nemestrina. |
| PubMed:Saliva tannin interactions. |
| PubMed:Inhibitory effects of apple polyphenols and related compounds on cariogenic factors of mutans streptococci. |
| PubMed:Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. |
| PubMed:Anti-oxidant, pro-oxidant properties of tannic acid and its binding to DNA. |
| PubMed:Mutagenicity and antimutagenicity studies of tannic acid and its related compounds. |
| PubMed:Free radical scavenging capacity in the aging of selected red Spanish wines. |
| PubMed:Chemopreventive activity of very low dose dietary tannic acid administration in hepatoma bearing C3H male mice. |
| PubMed:Molecular cloning, expression and characterization of a phenol sulfotransferase cDNA from mouse intestine. |
| PubMed:Effect of gelatin (a model for salivary PRP) on the sensory astringency of 5-O-caffeoylquinic acid and tannic acid. |
| PubMed:Tannins and human health: a review. |
| PubMed:Structural features of tannic acid important for DNA degradation in the presence of Cu(II). |
| PubMed:Adherence of two film-forming medications to the oral mucosa. |
| PubMed:Feeding and digesting fiber and tannins by an herbivorous rodent, Octodon degus (Rodentia:Caviomorpha). |
| PubMed:Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. |
| PubMed:Taste and olfactory processing in the brain and its relation to the control of eating. |
| PubMed:In vitro anticancer activity of fruit extracts from Vaccinium species. |
| PubMed:A quantitative model for prediction of iron bioavailability from Indian meals: an experimental study. |
| PubMed:Effect of blanching on the content of antinutritional factors in selected vegetables. |
| PubMed:[Factors which modify the nutritional state of iron: tannin content of herbal teas]. |
| PubMed:Study on the carcinogenicity of tannic acid in F344 rats. |
| PubMed:Tannic acid content in sorghum (Sorghum bicolour M.): effects of processing. |
| PubMed:DNA breakage by tannic acid and Cu(II): sequence specificity of the reaction and involvement of active oxygen species. |
| PubMed:Degradation of polyphenols (catechin and tannic acid) in the rat intestinal tract. Effect on colonic fermentation and faecal output. |
| PubMed:The blocking effect of phenolic acid on N-nitrosomorpholine formation in vitro. |
| PubMed:Tannins in treehole habitats and their effects on Aedes sierrensis (Diptera: Culicidae) production and parasitism by Lambornella clarki (Ciliophora: Tetrahymenidae). |
| PubMed:Preference and aversion for deterrent chemicals in two species of Peromyscus mouse. |
| PubMed:[Study and preparation of Vi-PHA reagent and its application for detection of Salmonella typhi carriers]. |
| PubMed:The nutritive quality of sorghum-commonbean tempe. |
| PubMed:Green tea composition, consumption, and polyphenol chemistry. |
| PubMed:Role of antioxidants and scavengers on argemone oil-induced toxicity in rats. |
| PubMed:DNA damage by smoke: protection by turmeric and other inhibitors of ROS. |
| PubMed:Changes in some antinutrients of cowpeas (Vigna unguiculata) processed with 'kanwa' alkaline salt. |
| PubMed:[Subchronic oral toxicity study of tannic acid in F344 rats]. |
| PubMed:Effects of native and oxidized phenolic compounds on sucrase activity in rat brush border membrane vesicles. |
| PubMed:Dietary phenolic compounds: inhibition of Na+-dependent D-glucose uptake in rat intestinal brush border membrane vesicles. |
| PubMed:[Effect of the seed coat on the hardening of common beans (Phaseolus vulgaris)]. |
| PubMed:Failure of tannic acid to inhibit digestion or reduce digestibility of plant protein in gut fluids of insect herbivores : Implications for theories of plant defense. |
| PubMed:[Dehulling of sorghum in grinding mills]. |
| PubMed:Tannin analysis of food products. |
| PubMed:Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities. |
| PubMed:Inhibitory effects of phenolics, teas and saliva on the formation of mutagenic nitrosation products of salted fish. |
| PubMed:Drug-nitrite interactions in human saliva: effects of food constituents on carcinogenic N-nitrosamine formation. |
| PubMed:Modes of action of gallic acid in suppressing food intake of rats. |
| PubMed:A mutagenicity methodology for assessing the formation of N-dimethylnitrosamine in vivo. |
| PubMed:[Digestive and metabolic utilization of dietary nitrogen in rats receiving tannic acid, sulfite and ethanol, administrated singly or in combination]. |
| PubMed:Chemical interactions between thiamin and tannic acid. I. Kinetics, oxygen dependence and inhibition by ascorbic acid. |
| PubMed:Tannic acid: acute hepatotoxicity following administration by feeding tube. |
| PubMed:[Effects of tannic acid and potassium metabisulfite in combination with ethanol on some enzymatic detoxication activities of rat liver microsomes]. |
| PubMed:Effect of various agents in alleviating the toxicity of tannic acid for chickens. |
| PubMed:Food intake depression and other metabolic effects of tannic acid in the rat. |
| PubMed:[Effect of tannic acid on intestinal absorption in the mouse]. |
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tsca definition 2008: gallic acid derivatives found in nutgalls, bark and other plant parts, especially oak bark. Clarifying agent for beer and wine; flavour enhancer, colour modifier, pH control agent. Permitted boiler water additive in generation of steam for use in food contact processes
Tannins are astringent, bitter-tasting plant polyphenols that bind and precipitate proteins. The term tannin refers to the source of tannins used in tanning animal hides into leather; however, the term is widely applied to any large polyphenolic compound containing sufficient hydroxyls and other suitable groups (such as carboxyls) to form strong complexes with proteins and other macromolecules. Tannins have molecular weights ranging from 500 to over 3,000. Tannins are usually divided into hydrolyzable tannins and condensed tannins (proanthocyanidins). At the center of a hydrolyzable tannin molecule, there is a polyol carbohydrate (usually D-glucose). The hydroxyl groups of the carbohydrate are partially or totally esterified with phenolic groups such as gallic acid (in gallotannins) or ellagic acid (in ellagitannins). Hydrolyzable tannins are hydrolyzed by weak acids or weak bases to produce carbohydrate and phenolic acids. Condensed tannins, also known as proanthocyanidins, are polymers of 2 to 50 (or more) flavonoid units that are joined by carbon-carbon bonds, which are not susceptible to being cleaved by hydrolysis. While hydrolyzable tannins and most condensed tannins are water soluble, some very large condensed tannins are insoluble. Tannins may be employed medicinally in antidiarrheal, hemostatic, and antihemorrhoidal compounds. Also, they produce different colors with ferric chloride (either blue, blue black, or green to greenish black) according to the type of tannin. Examples of gallotannins are the gallic acid esters of glucose in tannic acid (C76H52O46), found in the leaves and bark of many plant species. Foods with tannins include tea, wine and some fruits (Wikipedia). [HMDB]
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