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methyl paraben
methyl 4-hydroxybenzoate

Supplier Sponsors

Name:methyl 4-hydroxybenzoate
CAS Number: 99-76-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-785-7
FDA UNII: A2I8C7HI9T
Nikkaji Web:J3.996I
Beilstein Number:0509801
MDL:MFCD00002352
XlogP3:2.00 (est)
Molecular Weight:152.14936000
Formula:C8 H8 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants and preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1490 Methyl Paraben View - review
EU SANCO p-hydroxybenzoates (PHB) View - review
EU SANCO Methyl p-hydroxybenzoate View - review
JECFA Food Additive: Methyl p-Hydroxybenzoate
GSFA Codex: Methyl para-hydroxybenzoate (218)
DG SANTE Food Additives:methyl p-hydroxybenzoate
DG SANTE Food Contact Materials:methyl p-hydroxybenzoate
FEMA Number:2710 methyl 4-hydroxybenzoate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):99-76-3 ; METHYL P-HYDROXYBENZOATE
FDA Regulation:
FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.23 Antimycotics.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1490 Methylparaben.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: Yes
Melting Point: 125.00 to 128.00 °C. @ 760.00 mm Hg
Boiling Point: 275.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.006000 mmHg @ 25.00 °C. (est)
Flash Point: 241.00 °F. TCC ( 116.11 °C. )
logP (o/w): 1.960
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, 5981 mg/L @ 25 °C (est)
 ether
 propylene glycol
 water, 2500 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Description:odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
Acme-Hardesty
Methyl Paraben
Odor: characteristic
Use: Antimicrobial Preservative Used in Cosmetics and Personal Care.
Alfa Biotechnology
For experimental / research use only.
Methylparaben 98%
BOC Sciences
For experimental / research use only.
Methyl 4-hydroxybenzoate
Charkit Chemical
METHYL PARABEN NF
ECSA Chemicals
METHYL PARABEN
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
EMD Millipore
For experimental / research use only.
Methyl 4-hydroxybenzoate
sds
ExtraSynthese
For experimental / research use only.
Methyl-4-hydroxybenzoate (GC) ≥99%
Foodchem International
Methyl Paraben
Glentham Life Sciences
Methyl 4-hydroxybenzoate, Ph. Eur. grade
HallStar
CoSept(tm) M
Odor: characteristic
Use: CoSept M is an extra fine white powder with faint odor that is non-hygroscopic and generally recognized as safe (GRAS) for use as a preservative in foods. For over 50 years this neutral ester of para-hydroxybenzoic acid has functioned as an excellent bacteriostatic and fungistatic agent at low concentration against a wide range of organisms. It is stable and active from pH 3 to 8, and is often used in conjunction with other additives (e.g., EDTA or its salts, Quaternium-15, Diazolidinyl Urea, Propylparaben) for synergistic effects. In personal care products, CoSept M and CoSept P have typically been used in combination (0.2% Methylparaben and 0.1% Propylparaben, with levels adjusted to specific circumstances). CoSept M has limited solubility in water, so presolubilization can reduce dissolution time and therefore batching time. The preference for parabens continues due to their 50-year history of safety and reliability.
HallStar
METHYL PARABEN
Odor: characteristic
Use: Methyl Paraben is an extra fine white powder with faint odor that is non-hygroscopic and generally recognized as safe (GRAS) for use as a preservative in foods. For over 50 years this neutral ester of para-hydroxybenzoic acid has functioned as an excellent bacteriostatic and fungistatic agent at low concentration against a wide range of organisms. It is stable and active from pH 3 to 8, and is often used in conjunction with other additives (e.g., EDTA or its salts, Quaternium-15, Diazolidinyl Urea, Propylparaben) for synergistic effects. In personal care products, Methylparaben and Propylparaben have typically been used in combination (0.2% Methylparaben and 0.1% Propylparaben, with levels adjusted to specific circumstances). Methyl Paraben has limited solubility in water, so presolubilization can reduce dissolution time and therefore batching time. The preference for parabens continues due to their 50-year history of safety and reliability.
Indis NV
For experimental / research use only.
Methyl Paraben
Kingyoung Bio Technical
Methylparaben
Kraft Chemical
Methyl Paraben
Nanjing Jiancheng Chemical
Methylparaben(Nipagin)
Odor: characteristic
Use: Methylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives. With excellent biological degradation function, it is a highly efficient emulsification stabilizer.
Penta International
METHYL-4-HYDROXYBENZOATE FCC
Penta International
METHYL-P-HYDROXYBENZOATE NF - EP GRADE
Penta International
METHYL-P-HYDROXYBENZOATE NF
Penta International
METHYL-p-HYDROXYBENZOATE
Santa Cruz Biotechnology
For experimental / research use only.
Methyl Paraben
Shiva Chemicals and Pharmaceuticals
Methyl Parabean
Sigma-Aldrich
Methyl 4-hydroxybenzoate, ≥99%, FCC
sds
Certified Food Grade Products
Sinofi Food Ingredients
Methylparaben
Odor: characteristic
Use: Preservative, Cosmetics, Feed, Pharmaceutical, Antimicrobial, Antifungal, Antibacterial, Soft Drink, Alcohol Beverage, Beverage Powder, Fruit Juice, Puddings, Sauces, Baking Food, Sauage, Food Colors, Milk, Wine, Flavoring Agent.
TCI AMERICA
For experimental / research use only.
Methyl 4-Hydroxybenzoate >99.0%(HPLC)(T)
sds
TRI-K Industries
TRIsept M (USP/NF/BP)
Odor: characteristic
Use: A widely used, effectual, cost effective cosmetic preservative.
Zhong Ya Chemical
Methyl Parabens (India)
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 960 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.

oral-guinea pig LD50 3000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.

oral-mouse LD50 > 8000 mg/kg
BEHAVIORAL: ATAXIA PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.

oral-rabbit LD50 6000 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 81, 1974.

Dermal Toxicity:
subcutaneous-mouse LD50 1200 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960.

subcutaneous-rat LD50 > 500 mg/kg
Clinical Toxicology. Vol. 4(2), Pg. 185, 1971.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antioxidants and preservatives
Recommendation for methyl paraben usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 5.000008.00000
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -5.00000
fruit ices: -5.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):99-76-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7456
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
methyl 4-hydroxybenzoate
Chemidplus:0000099763
RTECS:DH2450000 for cas# 99-76-3
 
References:
 methyl 4-hydroxybenzoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:99-76-3
Pubchem (cid):7456
Pubchem (sid):134972055
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):D01400
HMDB (The Human Metabolome Database):HMDB32572
FooDB:FDB010509
Export Tariff Code:2918.29.7500
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•topical antibiotic or corticosteroid preparations usually contain 0.3% parabens; however, ointments of tetracyclines contain 3% and some surgical powders of tetracyclines contain as much as 20% parabens. parabens •methylparaben usp methylparaben and propylparaben solution (preserved water) •grade: united states pharmacopeia, "food chemical codex" •the esters are usually dissolved in boiling water and then added to prepn, but when no water is present in formula they may be dissolved in alcohol, acetone, triethanolamine, glycerin, perfume oils, or melted fats. parabens •a combination of 0.18% methylparaben and 0.02% propylparaben is approved for use as preservative for certain parenteral solutions, eg, aq procaine penicillin suspensions. •trade names: abiol, aseptoform, maseptol, metaben, methaben, methyl butex, methyl chemosept, methyl parasept, methylben, metoxyde, moldex, nipagin, nipagin m, paridol, preserval, septos, solbrol, solbrol m, and tegosept m.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 saffron
Search Trop Picture
 
Synonyms:
 aseptoform
 benzoic acid, 4-hydroxy-, methyl ester
 benzoic acid, p-hydroxy-, methyl ester
4-(carbomethoxy)phenol
p-carbomethoxyphenol
para-carbomethoxyphenol
4-hydroxy methyl benzoate
4-hydroxy-benzoic acid methyl ester
4-hydroxybenzoic acid methyl ester
p-hydroxybenzoic acid methyl ester
para-hydroxybenzoic acid methyl ester
4-hydroxybenzoic acid methylester
4-hydroxybenzoic acid, methyl ester
p-hydroxybenzoic acid, methyl ester
p-hydroxybenzoic methyl ester
 killitol
 maseptol
 mekkings M
 metaben
 metagin
 methaben
p-methoxycarbonyl phenol
para-methoxycarbonyl phenol
4-(methoxycarbonyl) phenol
4-(methoxycarbonyl)phenol
p-methoxycarbonylphenol
 methyl 4-hydroxybenzoate
 methyl butex
 methyl chemosept
 methyl ester of p-hydroxybenzoic acid
 methyl p-hydroxybenzoate
 methyl p-oxybenzoate
 methyl para-hydroxybenzoate
 methyl para-oxybenzoate
 methyl parabens (india)
 methyl parasept
 methyl-4-hydroxybenzoate
 methyl-4-hydroxybenzoate FCC
 methyl-p-hydroxybenzoate
 methyl-p-hydroxybenzoate NF
 methylben
 methylparaben
 metoxyde
 moldex
 nipagin
 para M
 paradol
 paridol
 preserval
 solbrol
 tegosept
 

Articles:

PubMed:Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes.
PubMed:Exposure to the polyester PET precursor--terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells.
PubMed:Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products.
PubMed:Prevalence of sensitivity to food and drug additives in patients with chronic idiopathic urticaria.
PubMed:Antimicrobial and antibiofilm effects of selected food preservatives against Salmonella spp. isolated from chicken samples.
PubMed:Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece.
PubMed:Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure.
PubMed:Solubilization of parabens in aqueous Pluronic solutions: investigating the micellar growth and interaction as a function of paraben composition.
PubMed:[Determination of sixteen food additives in beverage by capillary zone electrophoresis].
PubMed:Occurrence and human exposure of p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE), and their hydrolysis products in indoor dust from the United States and three East Asian countries.
PubMed:p-Hydroxybenzoate esters metabolism in MCF7 breast cancer cells.
PubMed:Evaluation of the occurrence and biodegradation of parabens and halogenated by-products in wastewater by accurate-mass liquid chromatography-quadrupole-time-of-flight-mass spectrometry (LC-QTOF-MS).
PubMed:Fast and sensitive high performance liquid chromatography analysis of cosmetic creams for hydroquinone, phenol and six preservatives.
PubMed:Urinary concentrations of parabens and serum hormone levels, semen quality parameters, and sperm DNA damage.
PubMed:Use of a capillary tube for collecting an extraction solvent lighter than water after dispersive liquid-liquid microextraction and its application in the determination of parabens in different samples by gas chromatography--flame ionization detection.
PubMed:Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006.
PubMed:Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry.
PubMed:Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk.
PubMed:Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels.
PubMed:Contribution to the study of the chemical composition of Verticillium albo-atrum secretions in liquid media.
PubMed:[In vitro susceptibility of a Staphylococcus spp. isolate to food preservatives].
PubMed:Evaluation of the health aspects of methyl paraben: a review of the published literature.
PubMed:Interaction of p-hydroxybenzoic esters with beta-cyclodextrin.
PubMed:Prediction of Listeria spp. growth as affected by various levels of chemicals, pH, temperature and storage time in a model broth.
PubMed:Inhibition of Listeria monocytogenes and Salmonella enteriditis by combinations of plant oils and derivatives of benzoic acid: the development of synergistic antimicrobial combinations.
PubMed:Irreversible paraben inhibition of glycolysis by Streptococcus mutans GS-5.
PubMed:Effects of Sorbic Acid and Methyl Paraben on Susceptibility of Alfalfa Leafcutting Bees (Megachile rotundata) to Chalkbrood (Ascosphaera aggregata)
PubMed:[Preservation and stability of corn tortillas at room temperature].
PubMed:Determination and confirmation of methyl p-hydroxybenzoate in royal jelly and other foods produced by the honey bee.
PubMed:Relationships between the resistance of yeasts to acetic, propanoic and benzoic acids and to methyl paraben and pH.
PubMed:Inhibition by antimicrobial food additives of ochratoxin A production by Aspergillus sulphureus and Penicillium viridicatum.
 
Notes:
used as a preservative in cosmetics but potentiates uv-induced damage of skin. Antimicrobial agent, preservative, flavouring agent. Constit. of cloudberry, yellow passion fruit, white wine, botrytised wine and Bourbon vanilla
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