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Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellow powder (est) |
| Assay: | 97.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 131.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 350.00 to 353.00 °C. @ 760.00 mm Hg
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| Congealing Point: | 132.00 °C.
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| Vapor Pressure: | 0.000084 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 200.00 °F. TCC ( > 93.33 °C. )
|
| logP (o/w): | 4.839 (est) |
| Soluble in: |
| | 1.05 gms to 100 gms alcohol | | | 16.7 gms to 100 gms benzyl benzoate | | | 4.19 gms to 100 gms methyl carbitol | | | 24.2 gms to 100 gms diethyl phthalate | | | 25.9 gms to 100 gms dimethyl phthalate | | | water, 0.1661 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor Type: musk |
Odor Strength:medium ,
recommend smelling in a 10.00 % solution or less |
| Substantivity:400 hour(s) at 20.00 % |
| sweet musk ambrette powdery dry |
Odor Description:at 10.00 % in benzyl benzoate. sweet musk ambrette ketone powdery dry
Luebke, William tgsc, (1985) |
| Odor sample from: Givaudan Corporation |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| 1,1,3,3,5-PENTAMETHYL-4,6-DINITROINDANE
|
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Musk moskene solution
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| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| 4,6-Dinitro-1,1,3,3,5-pentamethylindane
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Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 885, 1979.
|
| Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 885, 1979.
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| IFRA Critical Effect: | | Insufficient data |
| | View the IFRA Standard |
| Recommendation for moskene (Givaudan) usage levels up to: | | | PROHIBITED: Should not be used as a fragrance ingredient.
|
| |
| Recommendation for moskene (Givaudan) flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1-tert- | butyl-3,5-dinitro-1-isopropyl-4-methylbenzene | | 4,6- | dinitro-1,1,3,3,5-pentamethyl indan | | 4,6- | dinitro-1,1,3,3,5-pentamethylindan | | 4,6- | dinitro-1,1,3,3,5-pentamethylindane | | | indan, 1,1,3,3,5-pentamethyl-4,6-dinitro- | | | indan, 4,6-dinitro-1,1,3,3,5-pentamethyl- | | 1H- | indene, 2,3-dihydro-1,1,3,3,5-pentamethyl-4,6-dinitro- | | | moskene (Givaudan) | | | musk moskene | | 1,1,3,3,5- | pentamethyl-4,6-dinitro-2,3-dihydro-1H-indene | | 1,1,3,3,5- | pentamethyl-4,6-dinitro-2H-indene | | 1,2,3,3,5- | pentamethyl-4,6-dinitro-indan | | 1,1,3,3,5- | pentamethyl-4,6-dinitroindan | | 1,1,3,3,5- | pentamethyl-4,6-dinitroindane | | 1,1,3,3,5- | pentamethyl-4,6-dinitrolindan |
Articles:
| PubMed:Headspace stir bar sorptive extraction followed by thermal desorption and gas chromatography with mass spectrometry to determine musk fragrances in sludge samples without sample pretreatment. |
| PubMed:Analysis of 7 synthetic musks in cream by supported liquid extraction and solid phase extraction followed by GC-MS/MS. |
| PubMed:Determination of polycyclic and nitro musks in environmental water samples by means of microextraction by packed sorbents coupled to large volume injection-gas chromatography-mass spectrometry analysis. |
| PubMed:[Determination of synthetic nitro-musks in cosmetics by gas chromatography coupled with negative chemical ionization-triple quadrupole mass spectrometry]. |
| PubMed:Fully automated ionic liquid-based headspace single drop microextraction coupled to GC-MS/MS to determine musk fragrances in environmental water samples. |
| PubMed:Determination of synthetic musk compounds in indoor house dust by gas chromatography-ion trap mass spectrometry. |
| PubMed:Multicomponent analytical methodology to control phthalates, synthetic musks, fragrance allergens and preservatives in perfumes. |
| PubMed:High-sensitivity analysis of six synthetic musks by ultra-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry. |
| PubMed:Occurrence of synthetic musks in indoor dust from China and implications for human exposure. |
| PubMed:Optimization of a sensitive method for the determination of nitro musk fragrances in waters by solid-phase microextraction and gas chromatography with micro electron capture detection using factorial experimental design. |
| PubMed:Analysis of neutral nitromusks in incenses by capillary electrophoresis in organic solvents and gas chromatography-mass spectrometry. |
| PubMed:Simultaneous congener-specific determination of selected organochlorine compounds and nitro musks in human whole blood samples by solid-phase extraction and capillary gas chromatography with electron capture detection. |
| PubMed:Estrogenic activity of cosmetic components in reporter cell lines: parabens, UV screens, and musks. |
| PubMed:Further solid-phase microextraction-gas chromatography-mass spectrometry applications: "on-fibre" and aqueous photodegradation of nitro musks. |
| PubMed:Determination of musk compounds in sewage treatment plant sludge samples by solid-phase microextraction. |
| PubMed:Nitromusk compounds in women with gynecological and endocrine dysfunction. |
| PubMed:Analysis of nitro musk compounds and their amino metabolites in liquid sewage sludges using NMR and mass spectrometry. |
| PubMed:Kinetics of nitromusk compounds degradation in water by ultraviolet radiation and hydrogen peroxide. |
| PubMed:Nitro musks, nitro musk amino metabolites and polycyclic musks in sewage sludges. Quantitative determination by HRGC-ion-trap-MS/MS and mass spectral characterization of the amino metabolites. |
| PubMed:Interactions of nitromusk parent compounds and their amino-metabolites with the estrogen receptors of rainbow trout (Oncorhynchus mykiss) and the South African clawed frog (Xenopus laevis). |
| PubMed:Toxicity of nitromusks in early lifestages of South African clawed frog (Xenopus laevis) and zebrafish (Danio rerio). |
| PubMed:Contact allergy to musk moskene in a perfumed moisturizing cream. |
| PubMed:Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2. |
| PubMed:Nitro musk compounds genotoxic activity : Genotoxicity testing of nitro musks with the SOS-chromotest and the sister-chromatid exchange test. |
| PubMed:Occurrence of nitro and non-nitro benzenoid musk compounds in human adipose tissue. |
| PubMed:A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity. |
| PubMed:[Mutagenicity, genotoxicity and cogenotoxicity of environmentally relevant nitro musk compounds]. |
| PubMed:[Nitro-musk compounds in breast milk]. |
| PubMed:Pigmented contact dermatitis due to musk moskene. |
| PubMed:90-day dermal toxicity study and neurotoxicity evaluation of nitromusks in the albino rat. |
| PubMed:Photoallergic potential in the guinea-pig of the nitromusk perfume ingredients musk ambrette, musk moskene, musk xylene, musk ketone, and musk tibetene. |
| PubMed:Contact and photocontact allergy to musk ambrette. |
| PubMed:Phototoxicity, photoallergy, and contact sensitization of nitro musk perfume raw materials. |
| PubMed:Contact allergy to photoproducts of musk ambrette. |
| PubMed:Thin layer chromatography and high pressure liquid chromatography of musk ambrette and other nitromusk compounds including photopatch studies. |
| PubMed:Photosensitivity to musk ambrette. |
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3D/inchi