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Category:cosmetic ingredient for skin and hair care
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 98.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.92400 @ 25.00 °C.
|
| Melting Point: | -40.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 197.00 to 199.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.096000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.1 ( Air = 1 ) |
| Flash Point: | > 200.00 °F. TCC ( > 93.33 °C. )
|
| logP (o/w): | 0.004 (est) |
| Soluble in: |
| | alcohol | | | water, 3.256e+004 mg/L @ 25 °C (est) | | | water, 1.00E+06 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor Strength:none |
| Substantivity:400 Hour(s) |
Odor Description:at 100.00 %. odorless very mild green
Luebke, William tgsc, (1985) |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Arkema |
| Hexylene Glycol
Odor: characteristic Use: It is mainly used as a solvent or coupling agent. It is a potential substitute for glycol ethers. It is also an effective shrinkage reduction admixture or SRA for concrete and mortar. Hexylene glycol can also be used as a building block in chemical synthesis. |
| BOC Sciences |
| For experimental / research use only. |
| 2-Methyl-2,4-pentanediol >98%
Odor: characteristic Use: 2-Methyl-2,4-pentanediol, an analog of hexylene glycol, is a small molecular surfactant which could be useful as an environmentally friendly industrial coating solvent.
2-Methyl-2,4-pentanediol, an analog of hexylene glycol, is a small molecular surfactant which could be useful as an |
| Charkit Chemical |
| HEXYLENE GLYCOL
|
| ECSA Chemicals |
| HEXYLENE GLYCOL
|
| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| Indukern F&F |
| HEXYLENE GLYCOL
|
| Inoue Perfumery |
| HEXYLENE GLYCOL
|
| Lluch Essence |
| HEXYLENE GLYCOL
|
| Moellhausen |
| HEXYLEN GLYCOL
Odor: virtually odourless, mild oily, ethereal Flavor: mild, soft, slightly ethereal |
| Penta International |
| HEXYLENE GLYCOL NF
|
| Penta International |
| HEXYLENE GLYCOL
|
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| hexylene glycol 99%
|
| Silver Fern Chemical |
| Hexylene Glycol (HG)
Odor: characteristic Use: Hexylene glycol has many uses including hydraulic brake fluids, printing inks, a coupling agent for textiles, fuels and lubricants, emulsifying agent, cosmetics, and cleaners. |
| Wedor Corporation |
| HEXYLENE GLYCOL
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 3700 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 68, 1974.
oral-rabbit LD50 3200 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
LIVER: OTHER CHANGES
BEHAVIORAL: MUSCLE WEAKNESS
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.
oral-mouse LD50 3097 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 669, 1956.
intraperitoneal-mouse LD50 1299 mg/kg
Shell Chemical Company. Unpublished Report. Vol. -, Pg. 5, 1961.
oral-guinea pig LD50 2800 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: MUSCLE WEAKNESS
LIVER: OTHER CHANGES
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 4, Pg. 142, 1945.
intraperitoneal-rat LDLo 1500 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC
GASTROINTESTINAL: OTHER CHANGES
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED
Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.
|
| Dermal Toxicity: |
skin-rabbit LD50 8560 ul/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 731, 1969.
subcutaneous-rabbit LD50 13000 mg/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Food and Cosmetics Toxicology. Vol. 16, Pg. 777, 1978.
|
| Inhalation Toxicity: |
inhalation-rat LC50 > 310 mg/m3/1H
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 12-4/1970
inhalation-human TCLo 50 ppm/15M
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 312, 1969.
inhalation-mammal (species unspecified) TCLo 50 ppm
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 28, Pg. 262, 1946.
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Safety in Use Information:
| Category: | | cosmetic ingredient for skin and hair care |
| Recommendation for hexylene glycol usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for hexylene glycol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | blender |
| | emulsifying agents |
| | skin conditioning |
| | solvents |
| | surfactants |
Occurrence (nature, food, other): note
Synonyms:
| 2,4- | dihydroxy-2-methyl pentane | | 2,4- | dihydroxy-2-methylpentane | | 1,3- | dimethyl-3-hydroxybutanol | | | diolane | | | hexylen glycol | | (±)- | hexylene glycol | | | isol | | 2- | methyl pentane-2,4-diol | | 2- | methyl-2,4-pentandiol | | 4- | methyl-2,4-pentane diol | | 2- | methyl-2,4-pentanediol | | 2- | methylpentane-2,4-diol | | 2,4- | pentanediol, 2-methyl- | | | pinakon | | 1,1,3- | trimethyl trimethylene diol | | alpha,alpha,alpha'- | trimethyl trimethylene glycol | | 1,1,3- | trimethyl-1,3-propanediol | | 1,3,3- | trimethyl-1,3-propanediol | | 1,1,3- | trimethyltrimethylenediol |
Articles:
| PubMed:Refolding of SDS-denatured proteins using amphipathic cosolvents and osmolytes. |
| PubMed:Crystallization and preliminary X-ray analysis of peptidyl-tRNA hydrolase from Thermus thermophilus HB8. |
| PubMed:Crystal structure of silkworm Bombyx mori JHBP in complex with 2-methyl-2,4-pentanediol: plasticity of JH-binding pocket and ligand-induced conformational change of the second cavity in JHBP. |
| PubMed:Nanolitre-scale crystallization using acoustic liquid-transfer technology. |
| PubMed:Sequence-dependent effects of cryoprotectants on the active sites of the human ABO(H) blood group A and B glycosyltransferases. |
| PubMed:Structure-property relationship in new photo-cured dimethacrylate-based dental resins. |
| PubMed:A strategy for purifying glutathione S-transferase in the presence of sodium dodecyl sulfate. |
| PubMed:Atomic force microscopy imaging of human metaphase chromosomes in liquid. |
| PubMed:The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. |
| PubMed:2-Methyl-2,4-pentanediol induces spontaneous assembly of staphylococcal α-hemolysin into heptameric pore structure. |
| PubMed:Diffusion in ternary aqueous systems containing human serum albumin and precipitants of different classes. |
| PubMed:Properties of a new mouthrinse for patients receiving radiation therapy. |
| PubMed:PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler. |
| PubMed:Formulation of creams with betamethasone dipropionate: evaluation of chemical stability. |
| PubMed:Contact urticaria with systemic symptoms due to hexylene glycol in a topical corticosteroid: case report and review of hypersensitivity to glycols. |
| PubMed:Tryptophan as a three-way switch in regulating the function of the secretory signalling glycoprotein (SPS-40) from mammary glands: structure of SPS-40 complexed with 2-methylpentane-2,4-diol at 1.6 A resolution. |
| PubMed:Protecting role of cosolvents in protein denaturation by SDS: a structural study. |
| PubMed:Efficient low-power heteronuclear decoupling in 13C high-resolution solid-state NMR under fast magic angle spinning. |
| PubMed:Refolding SDS-denatured proteins by the addition of amphipathic cosolvents. |
| PubMed:High-resolution solid-state MAS NMR of proteins-Crh as an example. |
| PubMed:The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: a novel homodimer assembling and the implication for effector-binding mode. |
| PubMed:Aqueous self-assembly of phytantriol in ternary systems: effect of monoolein, distearoylphosphatidylglycerol and three water-miscible solvents. |
| PubMed:Isolation of Arabidopsis nuclei and measurement of gene transcription rates using nuclear run-on assays. |
| PubMed:A family of nanoporous materials based on an amino acid backbone. |
| PubMed:Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. |
| PubMed:Preferential hydration of DNA: the magnitude and distance dependence of alcohol and polyol interactions. |
| PubMed:Effect of organic cosolvents on the free solution mobility of curved and normal DNA molecules. |
| PubMed:Atomic force microscopy of native human metaphase chromosomes in a liquid. |
| PubMed:Effect of the solvent on the conformation of a depsipeptide: NMR-derived solution structure of hormaomycin in DMSO from residual dipolar couplings in a novel DMSO-compatible alignment medium. |
| PubMed:Pentane-1,5-diol as a percutaneous absorption enhancer. |
| PubMed:Polar body formation in Spisula oocytes: function of the peripheral aster. |
| PubMed:Induction of cytokinesis is independent of precisely regulated microtubule dynamics. |
| PubMed:A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase. |
| PubMed:Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. |
| PubMed:Crystalization and preliminary X-ray crystallographic analysis of the laminarinase endo-beta-1,3-glucanase from Pyrococcus furiosus. |
| PubMed:A redetermination of the structure of the triple mutant (K53,56,120M) of phospholipase A2 at 1.6 A resolution using sulfur-SAS at 1.54 A wavelength. |
| PubMed:Exclusion of alcohols from spermidine-DNA assemblies: probing the physical basis of preferential hydration. |
| PubMed:Characteristics of migration patterns of DNA oligomers in gels and the relationship to the question of intrinsic DNA bending. |
| PubMed:Microtubule plus-end dynamics in Xenopus egg extract spindles. |
| PubMed:The OH-initiated oxidation of hexylene glycol and diacetone alcohol. |
| PubMed:Increased temperature and 2-methyl-2,4-pentanediol change the DNA structure of both curved and uncurved adenine/thymine-rich sequences. |
| PubMed:Development of indomethacin Carbopol ETD 2001 gels and the influence of storage time and temperature on their stability. |
| PubMed:The crystal structure and stereospecificity of levodione reductase from Corynebacterium aquaticum M-13. |
| PubMed:Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2. |
| PubMed:Influence of storage time and temperature on the stability of indomethacin Pluronic F-127 gels. |
| PubMed:An overview on 2-methyl-2,4-pentanediol in crystallization and in crystals of biological macromolecules. |
| PubMed:Determination of glycols in biological specimens by gas chromatography-mass spectrometry. |
| PubMed:Pluronic F-127 gels as a vehicle for topical formulations of indomethacin and rheological behaviour of these formulations. |
| PubMed:KNI-272, a highly selective and potent peptidic HIV protease inhibitor. |
| PubMed:The 1.19 A X-ray structure of 2'-O-Me(CGCGCG)(2) duplex shows dehydrated RNA with 2-methyl-2,4-pentanediol in the minor groove. |
| PubMed:An open study of efficacy and safety of long-term treatment with mometasone furoate fatty cream in the treatment of adult patients with atopic dermatitis. |
| PubMed:Crystallization, structure solution and refinement of hen egg-white lysozyme at pH 8.0 in the presence of MPD. |
| PubMed:Bivariate flow cytometry DNA/BrdUrd analysis of plant cell cycle. |
| PubMed:Crystallographic studies on a family B DNA polymerase from hyperthermophilic archaeon Pyrococcus kodakaraensis strain KOD1. |
| PubMed:Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure. |
| PubMed:Non-flammable preparative reversed-phase liquid chromatography of recombinant human insulin-like growth factor-I. |
| PubMed:Division of polar bodies induced by their enlargement in the starfish Asterina pectinifera. |
| PubMed:Effects of neutral salts on RNA chain elongation and pausing by Escherichia coli RNA polymerase. |
| PubMed:Effect of the crystallizing agent 2-methyl-2,4-pentanediol on the structure of adenine tract DNA in solution. |
| PubMed:Comparison of the solution and crystal conformations of (G + C)-rich fragments of DNA. |
| PubMed:The organic crystallizing agent 2-methyl-2,4-pentanediol reduces DNA curvature by means of structural changes in A-tracts. |
| PubMed:Cosolvent-induced adsorption and desorption of serum proteins on an amphiphilic mercaptomethylene pyridine-derivatized agarose gel. |
| PubMed:MPD and DNA bending in crystals and in solution. |
| PubMed:What is the basis of sequence-directed curvature in DNAs containing A tracts? |
| PubMed:Dehydrating agents sharply reduce curvature in DNAs containing A tracts. |
| PubMed:Contribution of the surface free energy perturbation to protein-solvent interactions. |
| PubMed:High resolution structures of the 4-4-20 Fab-fluorescein complex in two solvent systems: effects of solvent on structure and antigen-binding affinity. |
| PubMed:High resolution detection of uncoated metaphase chromosomes by means of field emission scanning electron microscopy. |
| PubMed:Effect of hexylene glycol-altered microtubule distributions on cytokinesis and polar lobe formation in fertilized eggs of Ilyanassa obsoleta. |
| PubMed:Cosolvent modulation of the tubulin-colchicine GTPase-activating conformational change: strength of the enzymatic activity. |
| PubMed:Further evaluation of a new penetration enhancer, HPE-101. |
| PubMed:The alpha-helical content of calmodulin is increased by solution conditions favouring protein crystallisation. |
| PubMed:A high-yield procedure for isolation of metaphase chromosomes from root tips of Vicia faba L. |
| PubMed:Conditions for assembly of tubulin-based structures in unfertilized sea urchin eggs. Spirals, monasters and cytasters. |
| PubMed:The ultrastructure of Pityrosporum pachydermatis. |
| PubMed:Preparation and flow cytometric analysis of metaphase chromosomes of tomato. |
| PubMed:Change in the heterogeneous distribution of tubulin isotypes in mitotic microtubules of the sea urchin egg by treatment with microtubule depolymerizing or stabilizing drugs. |
| PubMed:Antibacterial and antifungal properties of propylene glycol, hexylene glycol, and 1,3-butylene glycol in vitro. |
| PubMed:Crystal structure of thioredoxin from Escherichia coli at 1.68 A resolution. |
| PubMed:[Effect of hexylene glycol on microtubular structures in starfish oocytes and sea urchin eggs]. |
| PubMed:Skin reactions to hexylene glycol. |
| PubMed:Three-dimensional structure of a fluorescein-Fab complex crystallized in 2-methyl-2,4-pentanediol. |
| PubMed:The genetic toxicology of some hydrocarbon and oxygenated solvents. |
| PubMed:Differences in crystal properties and ligand affinities of an antifluorescyl Fab (4-4-20) in two solvent systems. |
| PubMed:Phase diagrams for DNA crystallization systems. |
| PubMed:[The use of phase diagrams in the crystallization of oligonucleotide duplexes. I. A model of crystallization of the (pGpT)n.(pApC)n + spermine system]. |
| PubMed:Single crystals of hydrogenase from Desulfovibrio vulgaris Miyazaki F. |
| PubMed:Cytoskeleton of the unfertilized sea urchin egg. |
| PubMed:Oxygen consumption by tumor cells during membrane vesicle shedding. |
| PubMed:Dual effect of procaine in sea urchin eggs. Inducer and inhibitor of microtubule assembly. |
| PubMed:Effect of a nonsteroidal antiandrogen, flutamide, on androgen receptor dynamics and ornithine decarboxylase gene expression in mouse kidney. |
| PubMed:Nuclear androgen receptors in different stages of the seminiferous epithelial cycle and the interstitial tissue of rat testis. |
| PubMed:Nonaqueous fractionation of HeLa cells in glycols. |
| PubMed:Composition of the isolated mitotic apparatus: analysis by polyacrylamide gel electrophoresis. |
| PubMed:[Study of a lysis medium stabilizing microfilaments and microtubules in vitro and in vivo]. |
| PubMed:Structure of variant-3 scorpion neurotoxin from Centruroides sculpturatus Ewing, refined at 1.8 A resolution. |
| PubMed:Localization of estrogen receptor regulatory factor in the uterine nucleus. |
| PubMed:Selective crystallization of horse isoferritins. |
| PubMed:Chinese hamster metaphase chromosomes isolated under physiological conditions. A partial characterization of associated non-histone proteins and protein cores. |
| PubMed:Possible role of microtubules in tumor cell surface membrane shedding, permeability, and lympholysis. |
| PubMed:Preparation of calmodulin crystals. |
| PubMed:Stereo electron microscope studies of mitotic chromosomes from Chinese hamster ovary cells. |
| PubMed:Safety evaluation of some humectants and moisturizers used in cosmetic formulations. |
| PubMed:Parthenogenetic activation of sea urchin egg induces a cyclical variation of the cytoplasmic resistance to hexylene glycol-Triton X-100 treatment. |
| PubMed:Six polymorphic crystal forms of alpha-cobratoxin. |
| PubMed:A new method for the preparation of metaphase chromosomes for flow analysis. |
| PubMed:Packing DNA into chromosomes. |
| PubMed:Experimental determinations of tubulin in the in vivo mitotic apparatus of sea urchin zygotes. |
| PubMed:An analysis of spindle ultrastructure during prometaphase and metaphase of micronuclear division in Tetrahymena. |
| PubMed:Induction of cleavage in nucleated and enucleated frog eggs by injection of isolated sea-urchin mitotic apparatus. |
| PubMed:Studies on the de novo formation of centrioles: aster formation in the activated eggs of sea urchin. |
| PubMed:Cytochemical and ultrastructural studies on the synaptonemal complex of rat spermatocytes. |
| PubMed:Isolation of nuclei using hexylene glycol. |
| PubMed:Spindle birefringence of isolated mitotic apparatus: further evidence for two birefringent spindle components. |
| PubMed:The effect of vinblastine, colchicine and hexylene glycol on migration of human monocytes. |
| PubMed:Spindle birefringence of isolated mitotic apparatus analysed by pressure treatment. |
| PubMed:Studies on intracellular transport of secretory proteins in the rat exocrine pancreas. II. Inhibition of antimicrotubular agents. |
| PubMed:The avian erythrocyte: a study of fixation for electron microscopy. |
| PubMed:Colchicine-binding protein and the secretion of thyroid hormone. |
| PubMed:Electron probe analysis of freeze-substituted, epoxy resin embedded tissue for ion transport studies in plants. |
| PubMed:Purification of intact microtubules from brain. |
| PubMed:The mitotic apparatus. Physical chemical characterization of the 22S protein component and its subunits. |
| PubMed:The mitotic apparatus. Identification of the major soluble component of the glycol-isolated mitotic apparatus. |
| PubMed:The toxicity of 2-methylpentan-2, 4-diol (hexylene glycol) by chronic oral administration to rats and mice. |
| PubMed:The excretion of hexylene glycol (2-methyl-2,4-pentane diol) in man. |
| PubMed:Determination of 2-methyl-2,4-pentane diol (hexylene glycol) in the urine of man and rats. |
| PubMed:Local and systemic effects of 2-methyl 2,4 pentanediol (hexylene glycol). |
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3D/inchi