EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

methyl carbitol
ethanol, 2-(2-methoxyethoxy)-

Supplier Sponsors

Name:2-(2-methoxyethoxy)ethanol
CAS Number: 111-77-3Picture of molecule3D/inchi
Other(deleted CASRN):1552323-12-2
ECHA EINECS - REACH Pre-Reg:203-906-6
FDA UNII: 465DDJ8G8K
Nikkaji Web:J5.114D
Beilstein Number:1697812
MDL:MFCD00002871
XlogP3:-0.90 (est)
Molecular Weight:120.14824000
Formula:C5 H12 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:solvents/deluents for cosmetic and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):111-77-3 ; DIETHYLENE GLYCOL MONOMETHYL ETHER
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.02000 to 1.02400 @ 20.00 °C.
Pounds per Gallon - (est).: 8.497 to 8.531
Refractive Index:1.42400 to 1.42700 @ 20.00 °C.
Melting Point: -70.00 °C. @ 760.00 mm Hg
Boiling Point: 191.00 to 198.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.118000 mmHg @ 25.00 °C. (est)
Vapor Density:4.14 ( Air = 1 )
Flash Point: 191.00 °F. TCC ( 88.00 °C. )
logP (o/w): -1.156 (est)
Soluble in:
 alcohol
 water, 1e+006 mg/L @ 25 °C (est)
 water, 1.00E+06 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor Strength:low
Odor Description:at 100.00 %. mild musty
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: not used anymore
 
Suppliers:
BOC Sciences
For experimental / research use only.
2-(2-Methoxyethoxy) ethanol >99.0%(GC)
Eastman Chemical
DM Solvent
sds
99.0 wt % min.
Eastman Chemical
Eastman™ DM Solvent
sds
Odor: characteristic
Use: Eastman™ DM Solvent (Diethylene Glycol Monomethyl Ether) is a slow evaporating glycol ether solvent with a mild odor that is used in brushing lacquers and dye stains. Its low odor and good solubility for spirit-soluble dyes makes it useful in non-grain raising wood stains, printing inks, and dye pastes for textiles. Eastman™ DM Solvent is also used in stamp pad and stencil inks, as a diluent for hydraulic brake fluids, and as a deicer in jet fuel.
Penta International
METHYL CARBITOL
Shiva Chemicals and Pharmaceuticals
Diethylene Glycol Monomethyl Ether
Sigma-Aldrich
For experimental / research use only.
Diethylene glycol monomethyl ether purum, ≥99.0% (GC)
Silver Fern Chemical
Glycol Ether DM
Odor: characteristic
Use: Glycol Ether DM is valuable as a solvent in coating applications such as latex paint and wood stain. It is also used in textile applications such as printing and dyeing processes, and in printing inks.
TCI AMERICA
For experimental / research use only.
Diethylene Glycol Monomethyl Ether (stabilized with BHT) >99.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 63 - Possible risk of harm to the unborn child.
S 01/02 - Keep locked up and out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 53 - Avoid exposure - obtain special instructions before use.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 4 ml/kg
National Technical Information Service. Vol. OTS0520737

oral-guinea pig LD50 4160 mg/kg
GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

intraperitoneal-mouse LD50 2611 mg/kg
AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Naselennykh Mest. Hygiene in Populated Places. Vol. 29, Pg. 37, 1990.

oral-mouse LD50 8222 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: CYANOSIS AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC
Gigiena Naselennykh Mest. Hygiene in Populated Places. Vol. 29, Pg. 37, 1990.

oral-rabbit LD50 7190 mg/kg
National Technical Information Service. Vol. OTS0516797

intraperitoneal-rat LD50 2722 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Gigiena Naselennykh Mest. Hygiene in Populated Places. Vol. 29, Pg. 37, 1990.

Dermal Toxicity:
skin-rabbit LD50 2500 ul/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES
National Technical Information Service. Vol. OTS0516797

Inhalation Toxicity:
inhalation-rat LC > 2000 mg/m3/1H
National Technical Information Service. Vol. OTS0516703
 
Safety in Use Information:
Category:
solvents/deluents for cosmetic and fragrance agents
Recommendation for methyl carbitol usage levels up to:
 not for fragrance use.
 
Recommendation for methyl carbitol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):111-77-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8134
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:1
2-(2-methoxyethoxy)ethanol
Chemidplus:0000111773
EPA/NOAA CAMEO:hazardous materials
RTECS:111-77-3
 
References:
 2-(2-methoxyethoxy)ethanol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:111-77-3
Pubchem (cid):8134
Pubchem (sid):134975349
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2909.44.0110
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•phillips fuel additive 56 mb; active ingredient 99.7% diethylene glycol monomethyl ether •grade: technical
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 diethylene glycol monomethyl ether
 diglycol monomethyl ether
 DM solvent
 ethanol, 2-(2-methoxyethoxy)-
 glycol ether DM
 MECB
 methoxydiglycol
2-(2-methoxyethoxy) ethanol
2-(2-methoxyethoxy)-ethanol
2-(2-methoxyethoxy)ethan-1-ol
2-(2-methoxyethoxy)ethanol
 methyl carbitol
 methyldiglycol
 

Articles:

PubMed:A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: Synthesis and characterization of physical and toxicological properties.
PubMed:Oxidative metalation as a route to size-mismatched macrocyclic complexes: osmium corroles.
PubMed:The effect of amphiphilic polymers on the association, morphology and photophysical properties of hypocrellin coordination polymer/fullerene assemblies.
PubMed:Sensitivity improvement in hydrophilic interaction chromatography negative mode electrospray ionization mass spectrometry using 2-(2-methoxyethoxy)ethanol as a post-column modifier for non-targeted metabolomics.
PubMed:Os(II) phosphors with near-infrared emission induced by ligand-to-ligand charge transfer transition.
PubMed:Peptide hydrogels assembled from nonionic alkyl-polypeptide amphiphiles prepared by ring-opening polymerization.
PubMed:Lanthanum(III) catalysts for highly efficient and chemoselective transesterification.
PubMed:Imaging of lysosomal pH changes with a fluorescent sensor containing a novel lysosome-locating group.
PubMed:Detection of DNA damage in workers exposed to JP-8 jet fuel.
PubMed:(2-methoxyethoxy)acetic acid: a urinary biomarker of exposure for jet fuel JP-8.
PubMed:Lanthanum(III) isopropoxide catalyzed chemoselective transesterification of dimethyl carbonate and methyl carbamates.
PubMed:Ligand-assisted rate acceleration in lanthanum(III) isopropoxide catalyzed transesterification of carboxylic esters.
PubMed:Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes.
PubMed:Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis.
PubMed:Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether.
PubMed:Corrosion of aluminum alloy 2024 by microorganisms isolated from aircraft fuel tanks.
PubMed:Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine.
PubMed:Biomonitoring of 2-(2-alkoxyethoxy)ethanols by analysing urinary 2-(2-alkoxyethoxy)acetic acids.
PubMed:A Test Procedure for the Determination of (2-Methoxyethoxy)acetic Acid in Urine from Jet Fuel-Exposed Mice.
PubMed:Mechanism of the transition between lamellar and gyroid phases formed by a diblock copolymer in aqueous solution.
PubMed:A cohesion/tension mechanism explains the gating of water channels (aquaporins) in Chara internodes by high concentration.
PubMed:Procedure for the quantification of the biomarker (2-methoxyethoxy)acetic acid in human urine samples.
PubMed:Efficacy of two 65% permethrin spot-on formulations against induced infestations of Ctenocephalides felis (Insecta: Siphonaptera) and Amblyomma americanum (Acari: Ixodidae) on beagles.
PubMed:Efficacy of two 65 % permethrin spot-on formulations against canine infestations of Ctenocephalides felis and Rhipicephalus sanguineus.
PubMed:Maternal exposure to diethylene glycol monomethyl ether: a possible role in the etiology of retrocaval ureter.
PubMed:In vitro toxicities of experimental jet fuel system ice-inhibiting agents.
PubMed:Identification of rat urinary and biliary metabolites of esonarimod, a novel antirheumatic drug, using liquid chromatography/electrospray ionization tandem mass spectrometry with postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier.
PubMed:Assessment of skin absorption and penetration of JP-8 jet fuel and its components.
PubMed:Utility of postcolumn addition of 2-(2-methoxyethoxy)ethanol, a signal-enhancing modifier, for metabolite screening with liquid chromatography and negative ion electrospray ionization mass spectrometry.
PubMed:To what extent are biomonitoring data available in chemical risk assessment?
PubMed:Effects of diethylene glycol monomethyl ether on pregnancy and postnatal development in rats.
PubMed:Comparative metabolism of bis(2-methoxyethyl)ether in isolated rat hepatocytes and in the intact rat: effects of ethanol on in vitro metabolism.
PubMed:The effect of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether on hepatic gamma-glutamyl transpeptidase.
PubMed:First practical colorimetric assay of lithium in serum.
PubMed:Comparative immunosuppression of various glycol ethers orally administered to Fischer 344 rats.
PubMed:Induction of r-GTP by ethylene glycol monomethyl ether.
PubMed:Bis(2-methoxyethyl) ether: metabolism and embryonic disposition of a developmental toxicant in the pregnant CD-1 mouse.
PubMed:A numerical procedure for choosing effective, low toxicity plasticizers for glycol methacrylate embedding.
PubMed:Effect of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether on hepatic metabolizing enzymes.
PubMed:Acute oral toxicity of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether.
PubMed:Aspects of biological monitoring of exposure to glycol ethers.
PubMed:Metabolism of bis(2-methoxyethyl) ether in the adult male rat: evaluation of the principal metabolite as a testicular toxicant.
PubMed:Evaluation of 60 chemicals in a preliminary developmental toxicity test.
PubMed:Teratologic evaluation of dermally applied diethylene glycol monomethyl ether in rabbits.
PubMed:Developmental toxicity of diethylene glycol monomethyl ether (diEGME).
PubMed:A subchronic dermal exposure study of diethylene glycol monomethyl ether and ethylene glycol monomethyl ether in the male guinea pig.
PubMed:Diethylene glycol monomethyl ether 13-week vapor inhalation toxicity study in rats.
PubMed:Experimental studies on toxicity of ethylene glycol alkyl ethers in Japan.
PubMed:Further studies on the toxicology of the glycol ethers with emphasis on rapid screening and hazard assessment.
PubMed:Absorption of some glycol ethers through human skin in vitro.
PubMed:Biocidal properties of anti-icing additives for aircraft fuels.
 
Notes:
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