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costic acid
2-[(2R,4aR,8aS)-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid

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Name:2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
CAS Number: 3650-43-9Picture of molecule3D/inchi
FDA UNII: 6109CN8DDD
Nikkaji Web:J22.564I
XlogP3-AA:4.10 (est)
Molecular Weight:234.33874000
Formula:C15 H22 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.05010 @ 25.00 °C.
Boiling Point: 170.00 to 175.00 °C. @ 11.00 mm Hg
Flash Point: 507.00 °F. TCC ( 263.80 °C. ) (est)
logP (o/w): 4.930 (est)
Soluble in:
 water, 2.899 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
b-Costic acid 0.96
Odor: characteristic
Use: b-Costic acid isolated from the herb of Dittrichia graveolens.
Coompo
For experimental / research use only.
beta-Costic Acid from Plants ≥96%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for costic acid usage levels up to:
 not for fragrance use.
 
Recommendation for costic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6451579
National Institute of Allergy and Infectious Diseases:Data
2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
Chemidplus:0003650439
 
References:
 2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6451579
Pubchem (sid):135251604
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB35794
FooDB:FDB014544
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 burdock root
Search Trop Picture
 costus root oil
Search Trop Picture
 
Synonyms:
b-costic acid
beta-costic acid
(2R-(2alpha,4aalpha,8abeta))-decahydro-4a-methyl-alpha,8-bis(methylene)-2-naphthalene acetic acid
2-[(2R,4aR,8aS)-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid
2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
2-[(2R,4aR,8aS)-4a-methyl-8-methylidenedecahydronaphthalen-2-yl]prop-2-enoic acid
2-naphthaleneacetic acid, decahydro-4a-methyl-a,8-bis(methylene)-, (2R,4aR,8aS)-
 

Articles:

Google Patents:Use of costic acid or extracts of dittrichia viscosa against varroa destructor
PubMed:[Network pharmacology study on major active compounds of siwu decoction analogous formulae for treating primary dysmenorrhea of gynecology blood stasis syndrome].
PubMed:Inuloxins A-D, phytotoxic bi-and tri-cyclic sesquiterpene lactones produced by Inula viscosa: potential for broomrapes and field dodder management.
PubMed:[Chemical constituents of Dolomiaea souliei].
PubMed:[Study on chemical constituents from the roots of Saussurea lappa].
PubMed:Chemical composition and in vitro activity of plant extracts from Ferula communis and Dittrichia viscosa against postharvest fungi.
PubMed:Extracts of Inula viscosa Control Downy Mildew of Grapes Caused by Plasmopara viticola.
PubMed:PTP1B inhibitors from Saussrurea lappa.
PubMed:Antifeedant/insecticidal terpenes from asteraceae and labiatae species native to Argentinean semi-arid lands.
PubMed:Identification and quantitative determination of eudesmane-type acids from the essential oil of Dittrichia viscosa sp. viscosa using 13C-NMR spectroscopy.
PubMed:Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones.
PubMed:Eudesmane derivatives from Laggera pterodonta.
PubMed:Allelochemical effects of eudesmane and eremophilane sesquiterpenes on Tribolium castaneum larvae.
PubMed:Germacrenes from fresh costus roots.
PubMed:Mass spectral study of a sesquiterpene: gamma-costic acid.
PubMed:Sesquiterpenlactone aus berkheya-arten.
PubMed:Antibiotic principle of Eupatorium capillifolium.
 
Notes:
Constit. of the root of costus (Saussurea lappa)
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