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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white to pale yellow crystalline powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 145.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 311.89 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 288.00 °F. TCC ( 142.40 °C. ) (est)
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| logP (o/w): | 1.210 |
| Soluble in: |
| | water, 3500 mg/L @ 20 °C (exp) | | | water, 7970 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-bird - wild LD50 750 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
unreported-mammal (species unspecified) LD50 6310 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(6), Pg. 22, 1983.
intraperitoneal-mouse LD50 2500 mg/kg
Russian Pharmacology and Toxicology Vol. 37, Pg. 105, 1974.
intravenous-mouse LD50 > 500 mg/kg
Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1392, 1990.
oral-mouse LD50 1400 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 483, 1946.
oral-rat LD50 5410 mg/kg
BEHAVIORAL: EXCITEMENT
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 27(3), Pg. 52, 1983.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for ortho-anthranilic acid usage levels up to: | | | not for fragrance use.
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| Recommendation for ortho-anthranilic acid flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| ortho- | amidobenzoic acid | | 2- | amino benzoic acid | | 1- | amino-2-carboxybenzene | | 2- | amino-benzoic acid | | o- | amino-benzoic acid | | 2- | aminobenzoic acid | | o- | aminobenzoic acid | | ortho- | aminobenzoic acid | | | anthranic acid | | | anthranilic acid | | o- | anthranilic acid | | | benzoic acid, 2-amino- | | | benzoic acid, o-amino- | | | carboxyaniline | | 2- | carboxyaniline | | | vitamin L |
Articles:
| Google Patents:Manufacture of anthranilic acid |
| PubMed:Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. |
| PubMed:A fluorescence-based method for cyanate analysis in ethanol/water media: correlation between cyanate presence and ethyl carbamate formation in sugar cane spirit. |
| PubMed:Inhibition of proliferative responses of lymphocytes to food antigens by an anti-allergic drug, N(3',4'-dimethoxycinnamoyl) anthranilic acid (Tranilast) in children with atopic dermatitis. |
| PubMed:Characterisation of odorant compounds and their biochemical formation in green tea with a low temperature storage process. |
| PubMed:Accumulation of anthranilic acid and N-glucosylanthranilic acid by a Corynebacterium glutamicum mutant resistant to DL-serine hydroxamate. |
| PubMed:Large amounts of picolinic acid are lethal but small amounts increase the conversion of tryptophan-nicotinamide in rats. |
| PubMed:Improved determination of milk oligosaccharides using a single derivatization with anthranilic acid and separation by reversed-phase high-performance liquid chromatography. |
| PubMed:Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects. |
| PubMed:Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. |
| PubMed:Associations between intake of fish and n-3 long-chain polyunsaturated fatty acids and plasma metabolites related to the kynurenine pathway in patients with coronary artery disease. |
| PubMed:A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites. |
| PubMed:2-Pyridylfuran: a new fluorescent tag for the analysis of carbohydrates. |
| PubMed:Urinary excretory ratio of anthranilic acid/kynurenic acid as an index of the tolerable amount of tryptophan. |
| PubMed:Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users. |
| PubMed:The metabolites in the tryptophan degradation pathway might be useful to determine the tolerable upper intake level of tryptophan intake in rats. |
| PubMed:Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats. |
| PubMed:Fate of dietary tryptophan in young Japanese women. |
| PubMed:Quantification and characterization of enzymatically produced hyaluronan with fluorophore-assisted carbohydrate electrophoresis. |
| PubMed:Inhibition of interferon-gamma and interleukin-2 production from lymphocytes stimulated with food antigens by an anti-allergic drug, Tranilast, in patients with food-sensitive atopic dermatitis. |
| PubMed:Determination of methyl anthranilate in food samples by coupling stopped-flow mixing technique and time-resolved luminescence detection. |
| PubMed:Microwave assisted synthesis of 2,2'-arylene-substituted bis(4H-3,1-benzoxazin-4-one) derivatives using the complex cyanuric chloride/N,N-dimethylformamide. |
| PubMed:Evidence for significantly enhancing reduction of Azo dyes in Escherichia coli by expressed cytoplasmic Azoreductase (AzoA) of Enterococcus faecalis. |
| PubMed:Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea. |
| PubMed:Metabolism of azo dyes by human skin microbiota. |
| PubMed:Determination of sialyl and neutral oligosaccharide levels in transition and mature milks of Samoan women, using anthranilic derivatization followed by reverse phase high performance liquid chromatography. |
| PubMed:Effects of commercial processing on levels of antioxidants in oats (Avena sativa L.). |
| PubMed:Tryptophan catabolism in Brevibacterium linens as a potential cheese flavor adjunct. |
| PubMed:Structural characterization of N-linked oligosaccharides of laminin from rat kidney: changes during diabetes and modulation by dietary fiber and butyric acid. |
| PubMed:[Etiology of bladder cancer]. |
| PubMed:Non-steroidal anti-inflammatory analgesics other than salicylates. |
| PubMed:In vitro antioxidant activity and antigenotoxic effects of avenanthramides and related compounds. |
| PubMed:Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans. |
| PubMed:Influence of dose and sex on the disposition and hepatic effects of cinnamyl anthranilate in the B6C3F1 mouse. |
| PubMed:New potent DPPH radical scavengers from a marine-derived actinomycete strain USF-TC31. |
| PubMed:The historical aspects of sunscreens. |
| PubMed:Cinnamyl anthranilate causes coinduction of hepatic microsomal and peroxisomal enzymes in mouse but not rat. |
| PubMed:Cell action mechanism of tranilast--effect on the expression of HLA-class II antigen. |
| PubMed:Structural determination of hypnosin, a spore germination inhibitor of phytopathogenic Streptomyces sp. causing root tumor in melon (Cucumis sp.). |
| PubMed:FaGT2: a multifunctional enzyme from strawberry (Fragaria x ananassa) fruits involved in the metabolism of natural and xenobiotic compounds. |
| PubMed:The effects of phthalate esters on the tryptophan-niacin metabolism. |
| PubMed:Increase in conversion of tryptophan to niacin in pregnant rats. |
| PubMed:Avenanthramides in oats (Avena sativa L.) and structure-antioxidant activity relationships. |
| PubMed:Tryptanthrins and other tryptophan-derived agonists of the dioxin receptor. |
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3D/inchi