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R-clostridium histolyticum collagenase

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Category:cosmetic ingredient for skin conditioning

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	skin conditioning

Suppliers:

None found

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
cosmetic ingredient for skin conditioning
Recommendation for R-clostridium histolyticum collagenase usage levels up to:
	not for fragrance use.

Recommendation for R-clostridium histolyticum collagenase flavor usage levels up to:
	not for flavor use.

Safety References:

None found

References:

None found

Other Information:

Wikipedia:

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

clostridium histolyticum
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Synonyms:

R-	clostridium histolyticum collagenase

Articles:

PubMed:Peyronie's disease: What's around the bend?

PubMed:Role of collagenase clostridium histolyticum in Peyronie's disease.

PubMed:The Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis after Silicone Implants.

PubMed:Intralesional Injection of Interferon-α2b Improves Penile Curvature in Men with Peyronie's Disease Independent of Plaque Location.

PubMed:Therapeutic advances in the treatment of Peyronie's disease.

PubMed:Inhibitory effects of polyphenols from grape pomace extract on collagenase and elastase activity.

PubMed:Clinical safety and effectiveness of collagenase clostridium histolyticum injection in patients with Peyronie's disease: a phase 3 open-label study.

PubMed:Surgical correction of persistent Peyronie's disease following collagenase clostridium histolyticum treatment.

PubMed:Injectable Clostridium histolyticum collagenase as a potential treatment for uterine fibroids.

PubMed:Experience in the use of collagenase clostridium histolyticum in the management of Peyronie's disease: current data and future prospects.

PubMed:Technical tips for collagenase injection treatment for Dupuytren contracture.

PubMed:Early outcomes of a sequential series of 144 patients with Dupuytren's contracture treated by collagenase injection using an increased dose, multi-cord technique.

PubMed:Collagenase clostridium histolyticum for dupuytren contracture: patterns of use and effectiveness in clinical practice.

PubMed:Nonsurgical treatment of Dupuytren's contracture: 1-year US post-marketing safety data for collagenase clostridium histolyticum.

PubMed:Collagenase clostridium histolyticum injection for the treatment of Dupuytren's contracture.

PubMed:High molecular weight coffee melanoidins are inhibitors for matrix metalloproteases.

PubMed:Injectable collagenase Clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease.

PubMed:Tissue dissociation enzymes for isolating human islets for transplantation: factors to consider in setting enzyme acceptance criteria.

PubMed:The 105-kDa protein component of Bacillus cereus non-haemolytic enterotoxin (Nhe) is a metalloprotease with gelatinolytic and collagenolytic activity.

PubMed:Tenderization of beef with bacterial collagenase.

Notes:

a single chain recombinant Clostridium histolyticum protein, with one mutation, produced by fermentation in E. coli. The starting gene is directly isolated from Clostridium histolyticum which codes for the enzyme collagenase. The protein contains 925 amino acids and consists of the proper sequence of the 20 standard amino acids

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