capsicum oleoresin 8023-77-6

Appearance :	dark red viscous liquid (est)
Assay :	99.00 to 100.00 %
Food Chemicals Codex Listed :	No
Flash Point :	> 200.00 °F. TCC ( > 93.33 °C. )
Shelf Life :	12.00 month(s) or longer if stored properly.

Safety

Safety Information

Oral/Parenteral Toxicity :
	oral-rat LD50 > 3000 mg/kg BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toksikologicheskii Vestnik. Vol. (2), Pg. 14, 1995. intraperitoneal-rat LD50 248 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT Toksikologicheskii Vestnik. Vol. (2), Pg. 14, 1995.
Dermal Toxicity :
	skin-rat LD50 > 2500 mg/kg LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT Toksikologicheskii Vestnik. Vol. (2), Pg. 14, 1995.
Inhalation Toxicity :
	inhalation-rat LC50 > 10000 mg/m3/4H LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Toksikologicheskii Vestnik. Vol. (2), Pg. 14, 1995.

Safety in Use

Safety in Use Information

Category :	cosmetic and flavor agents
Recommendation for capsicum oleoresin fragrance usage levels up to :
	not for fragrance use.

Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA on the "Resources" link.
publication number : 3. Update in publication number(s) : 25
		average usual ppm	average maximum ppm
baked goods :		50.00000	85.00000
beverages(nonalcoholic) :		920.00000	105.00000
beverages(alcoholic) :		800.00000	900.00000
breakfast cereal :		25.00000	50.00000
cheese :		-	-
chewing gum :		450.00000	500.00000
condiments / relishes :		250.00000	330.00000
confectionery froastings :		20.00000	50.00000
egg products :		-	-
fats / oils :		100.00000	125.00000
fish products :		-	-
frozen dairy :		25.00000	28.00000
fruit ices :		-	-
gelatins / puddings :		18.00000	20.00000
granulated sugar :		-	-
gravies :		49.00000	50.00000
hard candy :		100.00000	150.00000
imitation dairy :		15.00000	25.00000
instant coffee / tea :		10.00000	0.15000
jams / jellies :		15.00000	25.00000
meat products :		75.00000	145.00000
milk products :		15.00000	25.00000
nut products :		50.00000	100.00000
other grains :		25.00000	40.00000
poultry :		-	-
processed fruits :		15.00000	50.00000
processed vegetables :		20.00000	25.00000
reconstituted vegetables :		-	-
seasonings / flavors :		100.00000	200.00000
snack foods :		50.00000	100.00000
soft candy :		100.00000	200.00000
soups :		25.00000	50.00000
sugar substitutes :		-	-
sweet sauces :		50.00000	75.00000

Safety References

European Food Safety Authority (EFSA) reference(s) :
Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy:page or pdf
ClinicalTrials.gov :	search
Daily Med :	search
EPA Substance Registry Services (TSCA) :	8023-77-6
EPA ACToR :	Toxicology Data
National Institute of Allergy and Infectious Diseases :	Data
WGK Germany :	3
	capsicum frutescens oleoresin
Chemidplus :	0008023776

Articles

Articles for the Flavor and Fragrance Industries

PubMed :	Formulation of a functional fat spread stabilised by natural antioxidants and emulsifiers.
PubMed :	Dietary plant extracts modulate gene expression profiles in ileal mucosa of weaned pigs after an Escherichia coli infection.
PubMed :	Dietary essential oils improve the hepatic antioxidative status of broiler chickens.
PubMed :	A mixture of carvacrol, cinnamaldehyde, and capsicum oleoresin improves energy utilization and growth performance of broiler chickens fed maize-based diet.
PubMed :	Immune and production responses of dairy cows to postruminal supplementation with phytonutrients.
PubMed :	Dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus.
PubMed :	Dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic Escherichia coli.
PubMed :	Dietary supplementation of young broiler chickens with Capsicum and turmeric oleoresins increases resistance to necrotic enteritis.
PubMed :	[On the stability of the irritant dibenz-[b,f]-[1,4]-oxazepine (substance CR)].
PubMed :	Effects of dietary addition of capsicum extract on intake, water consumption, and rumen fermentation of fattening heifers fed a high-concentrate diet.
PubMed :	Anti-inflammatory effects of several plant extracts on porcine alveolar macrophages in vitro.
PubMed :	Changes in carotenoids, ascorbic acids, and quality characteristics by the pickling of paprika (Capsicum annuum l.) cultivated in Korea.
PubMed :	Effects of dietary supplementation with phytonutrients on vaccine-stimulated immunity against infection with Eimeria tenella.
PubMed :	Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens.
PubMed :	Efficacy of capsicum oleoresin nanocapsules formulation by the modified emulsion-diffusion method.
PubMed :	The effect of vitamin E and plant extract mixture composed of carvacrol, cinnamaldehyde and capsaicin on oxidative stress induced by high PUFA load in young pigs.
PubMed :	Long-chain N-vanillyl-acylamides from Capsicum oleoresin.
PubMed :	High-throughput gene expression analysis of intestinal intraepithelial lymphocytes after oral feeding of carvacrol, cinnamaldehyde, or Capsicum oleoresin.
PubMed :	Dietary protein modifies effect of plant extracts in the intestinal ecosystem of the pig at weaning.
PubMed :	Separation of capsaicin from capsaicinoids by simulated moving bed chromatography.
PubMed :	Use of spray-cooling technology for development of microencapsulated capsicum oleoresin for the growing pig as an alternative to in-feed antibiotics: a study of release using in vitro models.
PubMed :	Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.
PubMed :	Effects of butyrate, avilamycin, and a plant extract combination on the intestinal equilibrium of early-weaned pigs.
PubMed :	Effects of spray-dried porcine plasma and plant extracts on intestinal morphology and on leukocyte cell subsets of weaned pigs.
PubMed :	The response of gastrointestinal microbiota to avilamycin, butyrate, and plant extracts in early-weaned pigs.
PubMed :	Influence of diet type on the inclusion of plant origin active substances on morphological and histochemical characteristics of the stomach and jejunum walls in chicken.
PubMed :	Capsicum oleoresin: development of an in-soil repellent for pocket gophers.
PubMed :	Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs.
PubMed :	[Inhibition of oxidation of human blood low density lipoproteins by carotenoids from paprika].
PubMed :	A 13-week subchronic toxicity study of paprika color in F344 rats.
PubMed :	Incorporation of carotenoids from paprika oleoresin into human chylomicrons.
PubMed :	Hypocholesterolaemic effect of the oleoresin of Capsicum annum L. in gerbils (Meriones hurrianae Jerdon).
PubMed :	Supercritical CO(2) and subcritical propane extraction of pungent paprika and quantification of carotenoids, tocopherols, and capsaicinoids.
PubMed :	Paprika (Capsicum annuum) oleoresin extraction with supercritical carbon dioxide.
PubMed :	Capsicum-laden soils decrease contact time by northern pocket gophers.
PubMed :	Unexpected death related to restraint for excited delirium: a retrospective study of deaths in police custody and in the community.
PubMed :	Isocratic non-aqueous reversed-phase high-performance liquid chromatographic separation of capsanthin and capsorubin in red peppers (Capsicum annuum L.), paprika and oleoresin.
PubMed :	Effects of oral chemical irritation on taste.