| Name: | lithospermum erythrorhizon root extract |
| CAS Number: | 223749-76-6 |
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| FDA UNII: | Search |
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | dark red liquid (est) |
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for lithospermum erythrorhizon root extract usage levels up to: | | | not for fragrance use.
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| Recommendation for lithospermum erythrorhizon root extract flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| National Institute of Allergy and Infectious Diseases:Data |
| lithospermum erythrorhizon root extract |
References:
| | lithospermum erythrorhizon root extract |
| Pubchem (cas): | 223749-76-6 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | extract of the dried roots of lithospermum erythrorhizon, boraginaceae | | purple | gromwell root extract | | red-root | gromwell root extract | | | lithospermum officinale var. erythrorhizon root extract |
Articles:
| PubMed:Pharmacological properties of shikonin - a review of literature since 2002. |
| PubMed:Topical herbal formulae in the management of psoriasis: systematic review with meta-analysis of clinical studies and investigation of the pharmacological actions of the main herbs. |
| PubMed:Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells. |
| PubMed:Traditional chinese medicine remedy to jury: the pharmacological basis for the use of shikonin as an anticancer therapy. |
| PubMed:Shikonin, a natural product from the root of Lithospermum erythrorhizon, is a cytotoxic DNA-binding agent. |
| PubMed:Beneficial effect of shikonin on experimental colitis induced by dextran sulfate sodium in BALB/c mice. |
| PubMed:Shikonin attenuates lipopolysaccharide-induced acute lung injury in mice. |
| PubMed:β,β-Dimethylacrylshikonin induces mitochondria dependent apoptosis through ERK pathway in human gastric cancer SGC-7901 cells. |
| PubMed:Novel multiple apoptotic mechanism of shikonin in human glioma cells. |
| PubMed:Inhibitory effects of β,β-dimethylacrylshikonin on hepatocellular carcinoma in vitro and in vivo. |
| PubMed:Dermocosmetics for dry skin: a new role for botanical extracts. |
| PubMed:Tigloylshikonin, a new minor Shikonin derivative, from the roots and the commercial root extract of lithospermum erythrorhizon. |
| PubMed:In vitro screening of tumoricidal properties of international medicinal herbs: part II. |
| PubMed:Lithospermic acid derivatives from Lithospermum erythrorhizon increased expression of serine palmitoyltransferase in human HaCaT cells. |
| PubMed:Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling. |
| PubMed:Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications. |
| PubMed:Cosmetic formulations containing Lithospermum erythrorhizon root extract show moisturizing effects on human skin. |
| PubMed:Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells. |
| PubMed:Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. |
| PubMed:Protection of human keratinocytes from UVB-induced inflammation using root extract of Lithospermum erythrorhizon. |
| PubMed:Non-radioactive and colorimetric quantification of monocyte adhesion to endothelial cells in early atherogenesis. |
| PubMed:Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages. |
| PubMed:Caffeic acid metabolites from Eritrichium sericeum cell cultures. |
| PubMed:Enhancement of natural pigment extraction using Bacillus species xylanase. |
| PubMed:Inhibitory effect of the Agrobacterium rhizogenes rolC gene on rabdosiin and rosmarinic acid production in Eritrichium sericeum and Lithospermum erythrorhizon transformed cell cultures. |
| PubMed:Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo. |
| PubMed:Shikonin, a component of chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type 1. |
| PubMed:High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon. |
| PubMed:Cellular pharmacology studies of shikonin derivatives. |
| PubMed:A novel dark-inducible protein, LeDI-2, and its involvement in root-specific secondary metabolism in Lithospermum erythrorhizon. |
| PubMed:Reaction of beta-alkannin (shikonin) with reactive oxygen species: detection of beta-alkannin free radicals. |
| PubMed:Genetic engineering on shikonin biosynthesis: expression of the bacterial ubiA gene in Lithospermum erythrorhizon. |
| PubMed:Simultaneous analysis of shikimate-derived secondary metabolites in Lithospermum erythrorhizon cell suspension cultures by high-performance liquid chromatography. |
| PubMed:Caffeic acid oligomers in Lithospermum erythrorhizon cell suspension cultures. |
| PubMed:Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene. |
| PubMed:Cell-specific production and antimicrobial activity of naphthoquinones in roots of lithospermum erythrorhizon |
| PubMed:Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro. |
| PubMed:cDNA cloning and gene expression of phenylalanine ammonia-lyase in Lithospermum erythrorhizon. |
| PubMed:Acylshikonin analogues: synthesis and inhibition of DNA topoisomerase-I. |
| PubMed:Shikonin production by extractive cultivation in transformed-suspension and hairy root cultures of Lithospermum erythrorhizon. |
| PubMed:[Screening test of crude drug extract on anti-HIV activity]. |
| PubMed:Shikonin production and secretion by hairy root cultures of Lithospermum erythrorhizon. |
| PubMed:Betanin Production and Release In Vitro from Suspension Cultures of Beta vulgaris. |
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