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Category:cosmetic, flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mammal (species unspecified) LD50 975 mg/kg
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988.
oral-mammal (species unspecified) LD50 2250 mg/kg
Zhongcaoyao. Chinese Traditional and Herbal Medicine. Vol. 19, Pg. 403, 1988.
intraperitoneal-mouse LD50 3300 mg/kg
KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Journal of Pharmaceutical Sciences. Vol. 50, Pg. 240, 1961.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic, flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
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| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 69.00000 |
| beverages(nonalcoholic): | - | 25.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | 24.00000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 35.00000 |
| fruit ices: | - | 35.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 65.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
| | valeriana officinalis l. rhizome/root extract |
| Pubchem (sid): | 135331255 |
Other Information:
| FDA Substances Added to Food (formerly EAFUS): | View |
| MedlinePlusSupp: | View |
| Wikipedia: | View |
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | extract of the rhizomes and roots of the valerian, valeriana officinalis l., valerianaceae | | | valerian rhizome/root extract |
Articles:
| PubMed:Valerenic Acid Protects Against Physical and Psychological Stress by Reducing the Turnover of Serotonin and Norepinephrine in Mouse Hippocampus-Amygdala Region. |
| PubMed:Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). |
| PubMed:Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. |
| PubMed:The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model. |
| PubMed:Can Valeriana officinalis root extract prevent early postoperative cognitive dysfunction after CABG surgery? A randomized, double-blind, placebo-controlled trial. |
| PubMed:The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats. |
| PubMed:Three new germacrane-type sesquiterpenes with NGF-potentiating activity from Valeriana officinalis var. latiofolia. |
| PubMed:Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. |
| PubMed:Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster. |
| PubMed:Valeriana officinalis Dry Plant Extract for Direct Compression: Preparation and Characterization. |
| PubMed:Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors. |
| PubMed:Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis). |
| PubMed:Effects of valerian consumption during pregnancy on cortical volume and the levels of zinc and copper in the brain tissue of mouse fetus. |
| PubMed:Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes. |
| PubMed:[Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies]. |
| PubMed:Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study. |
| PubMed:Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice. |
| PubMed:Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. |
| PubMed:Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia. |
| PubMed:Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. |
| PubMed:Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. |
| PubMed:In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. |
| PubMed:Relaxing effects of Valeriana officinalis extracts on isolated human non-pregnant uterine muscle. |
| PubMed:A feasibility study of valerian extract for sleep disturbance in person with arthritis. |
| PubMed:Preclinical toxicological assessment of a phytotherapeutic product--CPV (based on dry extracts of Crataegus oxyacantha L., Passiflora incarnata L., and Valeriana officinalis L.). |
| PubMed:Toxicological assessment of P-9801091 plant mixture extract after chronic administration in CBA/HZg mice--a biochemical and histological study. |
| PubMed:Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease. |
| PubMed:A randomized clinical trial of valerian fails to improve self-reported, polysomnographic, and actigraphic sleep in older women with insomnia. |
| PubMed:Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. |
| PubMed:Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. |
| PubMed:Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. |
| PubMed:Modulation of postsynaptic potentials in rat cortical neurons by valerian extracts macerated with different alcohols: involvement of adenosine A(1)- and GABA(A)-receptors. |
| PubMed:Interaction of valerian extracts of different polarity with adenosine receptors: identification of isovaltrate as an inverse agonist at A1 receptors. |
| PubMed:NF-kappaB modulators from Valeriana officinalis. |
| PubMed:Effects of aqueous, methanolic and chloroform extracts of rhizome and aerial parts of Valeriana officinalis L. on naloxone-induced jumping in morphine-dependent mice. |
| PubMed:New acylated clionasterol glycosides from Valeriana officinalis. |
| PubMed:A phase I clinical study of Andrographis paniculata fixed combination Kan Jang versus ginseng and valerian on the semen quality of healthy male subjects. |
| PubMed:Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. |
| PubMed:Multiple night-time doses of valerian (Valeriana officinalis) had minimal effects on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers. |
| PubMed:Neuroprotective properties of Valeriana officinalis extracts. |
| PubMed:Stability control of valerian ground material and extracts: a new HPLC-method for the routine quantification of valerenic acids and lignans. |
| PubMed:Assessing subjective and psychomotor effects of the herbal medication valerian in healthy volunteers. |
| PubMed:Analysis of responses to valerian root extract in the feline pulmonary vascular bed. |
| PubMed:Lignans isolated from valerian: identification and characterization of a new olivil derivative with partial agonistic activity at A(1) adenosine receptors. |
| PubMed:(-)-3 beta,4 beta-epoxyvalerenic acid from Valeriana officinalis. |
| PubMed:Polysomnographic evaluation of the hypnotic effect of Valeriana edulis standardized extract in patients suffering from insomnia. |
| PubMed:Synergy and other interactions in phytomedicines. |
| PubMed:Extracts and constituents of Hypericum perforatum inhibit the binding of various ligands to recombinant receptors expressed with the Semliki Forest virus system. |
| PubMed:Synaptosomal GABA release as influenced by valerian root extract--involvement of the GABA carrier. |
| PubMed:Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. |
| PubMed:[Effects of Valeriana officinalis L extract on cardiovascular system]. |
| PubMed:Quantifying the effects of mild sedatives. |
| PubMed:[Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. |
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