Name: | (2E,4E,6E,8E,10E,12E,14E,16E,18E)-4,8,13,17-tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid |
CAS Number: | 542-40-5 | 3D/inchi
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ECHA EINECS - REACH Pre-Reg: | 208-810-8 |
FDA UNII: | Search |
XlogP3-AA: | 7.20 (est) |
Molecular Weight: | 380.48396000 |
Formula: | C24 H28 O4 |
BioActivity Summary: | listing |
NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:coloring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Appearance: | dark red-brown to red-purple powder (est) |
Assay: | 85.00 to 100.00
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Food Chemicals Codex Listed: | No |
Boiling Point: | 640.37 °C. @ 760.00 mm Hg (est)
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Flash Point: | 671.00 °F. TCC ( 355.10 °C. ) (est)
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logP (o/w): | 5.532 (est) |
Soluble in: |
| alkaline water | | alcohol, slightly | | water, 0.005225 mg/L @ 25 °C (est) |
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Chr. Hansen A/S |
Annatto
Flavor: characteristic Annatto is the international food and beverage industry’s preferred natural color in orange shades ranging from light, yellowish orange to deep, dark orange. Chr. Hansen offers a full range of annatto natural color solutions including water-soluble, oil-soluble, acid-stable and encapsulated formulations, all with good light and heat stability. |
Rung International |
Annatto Nor Bixin Powder ( 1.5% Nor - Bixin )
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Safety Information:
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Hazards identification |
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Classification of the substance or mixture |
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
None found. |
GHS Label elements, including precautionary statements |
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Pictogram | |
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Hazard statement(s) |
None found. |
Precautionary statement(s) |
None found. |
Oral/Parenteral Toxicity: |
Not determined
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Dermal Toxicity: |
Not determined
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Inhalation Toxicity: |
Not determined
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Safety in Use Information:
Category: | coloring agents |
Recommendation for annatto seed extract (solvent-extracted norbixin) usage levels up to: | | not for fragrance use.
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Recommendation for annatto seed extract (solvent-extracted norbixin) flavor usage levels up to: |
| not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
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The safety of annatto extracts (E 160b) as a food additive View page or View pdf
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Exposure assessment of annatto colouring principles bixin and norbixin (E 160b) when used as food additives View page or View pdf
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EPI System: View |
AIDS Citations:Search |
Cancer Citations:Search |
EPA ACToR:Toxicology Data |
EPA Substance Registry Services (SRS):Registry |
National Institute of Allergy and Infectious Diseases:Data |
(2E,4E,6E,8E,10E,12E,14E,16E,18E)-4,8,13,17-tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid |
Chemidplus:0000542405 |
References:
| (2E,4E,6E,8E,10E,12E,14E,16E,18E)-4,8,13,17-tetramethylicosa-2,4,6,8,10,12,14,16,18-nonaenedioic acid |
NIST Chemistry WebBook: | Search Inchi |
Pubchem (cid): | 5281249 |
Pubchem (sid): | 135050098 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| annatto C | | bixa orellana seed extract (solvent-extracted norbixin) | | c.i. 75120 (solvent-extracted norbixin) | | ci 75120 (solvent-extracted norbixin) | | natural orange 4 (solvent-extracted norbixin) |
Articles:
Info:EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS |
PubMed:Gum arabic and Fe²⁺ synergistically improve the heat and acid stability of norbixin at pH 3.0-5.0. |
PubMed:Studies on interaction of norbixin with DNA: multispectroscopic and in silico analysis. |
PubMed:Short communication: norbixin and bixin partitioning in Cheddar cheese and whey. |
PubMed:Short communication: Development of a novel method for the extraction of norbixin from whey and its subsequent quantification via high performance liquid chromatography. |
PubMed:Inhibition of cyclophosphamide-induced oxidative stress in rat brain by polar and non-polar extracts of Annatto (Bixa orellana) seeds. |
PubMed:Probing the binding between norbixin and dairy proteins by spectroscopy methods. |
PubMed:Effect of bixin and norbixin on the expression of cytochrome P450 in HepG2 cell line. |
PubMed:A thirteen-week oral toxicity study of annatto extract (norbixin), a natural food color extracted from the seed coat of annatto (Bixa orellana L.), in Sprague-Dawley rats. |
PubMed:Prooxidant activity of norbixin in model of acute gastric ulcer induced by ethanol in rats. |
PubMed:Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo. |
PubMed:Raman spectroscopic determination of norbixin and tartrazine in sugar. |
PubMed:Characteristics of activated carbon and carbon nanotubes as adsorbents to remove annatto (norbixin) in cheese whey. |
PubMed:Bixin and norbixin have opposite effects on glycemia, lipidemia, and oxidative stress in streptozotocin-induced diabetic rats. |
PubMed:Contact sensitizing potential of annatto extract and its two primary color components, cis-bixin and norbixin, in female BALB/c mice. |
PubMed:Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. |
PubMed:Norbixin ingestion did not induce any detectable DNA breakage in liver and kidney but caused a considerable impairment in plasma glucose levels of rats and mice. |
PubMed:Digestive stability and transport of norbixin, a 24-carbon carotenoid, across monolayers of Caco-2 cells. |
PubMed:Effect of temperature and concentration on benzoyl peroxide bleaching efficacy and benzoic acid levels in whey protein concentrate. |
PubMed:Toxicity of the hyperglycaemic-inducing extract of the annatto (Bixa orellana) in the dog. |
PubMed:Induction of liver monooxygenases by annatto and bixin in female rats. |
PubMed:Extraction of an hyperglycaemic principle from the annatto (Bixa orellana), a medicinal plant in the West Indies. |
PubMed:Decolorization of Cheddar cheese whey by activated carbon. |
PubMed:Antigenotoxic and antimutagenic potential of an annatto pigment (norbixin) against oxidative stress. |
PubMed:Biochemical behaviour of norbixin during in vitro DNA damage induced by reactive oxygen species. |
PubMed:Time-of-flight secondary ion mass spectrometry and X-ray photoelectron spectroscopy analyses of Bixa orellana seeds. |
PubMed:Inhibitory effect of apocarotenoids on the activity of tyrosinase: Multi-spectroscopic and docking studies. |
PubMed:A synergistic effect of Cu(2+) and norbixin on DNA damage. |
PubMed:Bixin and norbixin in human plasma: determination and study of the absorption of a single dose of Annatto food color. |
PubMed:Generalized and rapid supramolecular solvent-based sample treatment for the determination of annatto in food. |
PubMed:Hypoglycaemic activity of Bixa orellana extract in the dog. |
PubMed:Cold enzymatic bleaching of fluid whey. |
PubMed:Determination of bixin and norbixin in meat using liquid chromatography and photodiode array detection. |
PubMed:[Detection of the annatto dye norbixin/bixin in cheese using derivative spectroscopy and high performance liquid chromatography (HPLC)]. |
PubMed:Alternative bleaching methods for Cheddar cheese whey. |
PubMed:Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. |
PubMed:High-performance liquid chromatographic separation of carminic acid, alpha- and beta-bixin, and alpha- and beta-norbixin, and the determination of carminic acid in foods. |
PubMed:The use of lactoperoxidase for the bleaching of fluid whey. |
PubMed:Effect of bleaching permeate from microfiltered skim milk on 80% serum protein concentrate. |
PubMed:Effect of temperature and bleaching agent on bleaching of liquid Cheddar whey. |
PubMed:The effect of microfiltration on color, flavor, and functionality of 80% whey protein concentrate. |
PubMed:Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice. |
PubMed:Sensory and Functionality Differences of Whey Protein Isolate Bleached by Hydrogen or Benzoyl Peroxide. |
PubMed:Influence of bleaching on flavor of 34% whey protein concentrate and residual benzoic acid concentration in dried whey proteins. |
PubMed:Short communication: The influence of solids concentration and bleaching agent on bleaching efficacy and flavor of sweet whey powder. |
PubMed:Influence of storage, heat treatment, and solids composition on the bleaching of whey with hydrogen peroxide. |
PubMed:Development of carotenoid storage cells in Bixa orellana L. seed arils. |
PubMed:Characterizing endogenous and exogenous peroxidase activity for bleaching of fluid whey and retentate. |
PubMed:Evaluation of certain food additives and contaminants. |
PubMed:Determination of annatto in high-fat dairy products, margarine and hard candy by solvent extraction followed by high-performance liquid chromatography. |
PubMed:Next generation sequencing and de novo transcriptome analysis of Costus pictus D. Don, a non-model plant with potent anti-diabetic properties. |
PubMed:Bixin regulates mRNA expression involved in adipogenesis and enhances insulin sensitivity in 3T3-L1 adipocytes through PPARgamma activation. |
PubMed:Bioautography and chemical characterization of antimicrobial compound(s) in commercial water-soluble annatto extracts. |
PubMed:The effect of starter culture and annatto on the flavor and functionality of whey protein concentrate. |
PubMed:Effect of bleaching whey on sensory and functional properties of 80% whey protein concentrate. |
PubMed:Method development and analysis of retail foods for annatto food colouring material. |
PubMed:The effect of bleaching agent on the flavor of liquid whey and whey protein concentrate. |
PubMed:Carotenoids and β-cyclodextrin inclusion complexes: Raman spectroscopy and theoretical investigation. |
PubMed:In vitro scavenging capacity of annatto seed extracts against reactive oxygen and nitrogen species. |
PubMed:Neuron-glial cell communication in the traumatic stress-induced immunomodulation. |
PubMed:Effect of natural pigments on the oxidative stability of sausages stored under refrigeration. |
PubMed:Evaluation of the clastogenicity and anticlastogenicity of the carotenoid bixin in human lymphocyte cultures. |
PubMed:Novel method for the determination of added annatto colour in extruded corn snack products. |
PubMed:Annatto constituent cis-bixin has selective antimyeloma effects mediated by oxidative stress and associated with inhibition of thioredoxin and thioredoxin reductase. |
PubMed:Invited review: Annatto usage and bleaching in dairy foods. |
PubMed:Reactive oxygen species mediate lethality induced by far-UV in Escherichia coli cells. |
PubMed:Biosynthesis of the food and cosmetic plant pigment bixin (annatto). |
PubMed:Analysis of annatto (Bixa orellana) food coloring formulations. 2. Determination of aromatic hydrocarbon thermal degradation products by gas chromatography. |
PubMed:Characterization of the principal colouring components of annatto using high performance liquid chromatography with photodiode-array detection. |
PubMed:Partial replacement of nitrite by annatto as a colour additive in sausage. |
PubMed:Structural analysis of the synaptic protein neuroligin and its beta-neurexin complex: determinants for folding and cell adhesion. |
PubMed:Chitosan microspheres containing the natural urucum pigment. |
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