| Name: | aesculus hippocastanum l. bark extract |
| CAS Number: | 8053-39-2 |
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| ECHA EC Number: | 232-497-7 |
| FDA UNII: | Search |
Category:astringent, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 2150 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.
oral-rat LD50 833 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.
intravenous-rat LD50 1450 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
intraperitoneal-rat LD50 13750 mg/kg
Drugs in Japan Vol. 6, Pg. 399, 1982.
oral-rabbit LD50 1530 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.
intravenous-rabbit LD50 400 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
intravenous-rabbit LD50 30 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
oral-mouse LD50 990 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.
oral-mouse LD50 164 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
oral-guinea pig LD50 1120 mg/kg
Drugs in Japan Vol. 6, Pg. 398, 1982.
intravenous-guinea pig LD50 37 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
intravenous-guinea pig LD50 940 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
intraperitoneal-mouse LD50 6700 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
intraperitoneal-mouse LD50 55 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 8, Pg. 45, 1980.
intravenous-mouse LD50 14400 ug/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
intravenous-mouse LD50 1377 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
intraperitoneal-rat LD50 10100 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
intravenous-rat LD50 62500 ug/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 263, 1960.
oral-rat LD50 833 mg/kg
Yakkyoku. Pharmacy. Vol. 33, Pg. 335, 1982.
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| Dermal Toxicity: |
subcutaneous-rat LD50 150 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
subcutaneous-mouse LD50 38500 ug/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 13, Pg. 349, 1982.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | astringent, skin conditioning |
| Recommendation for aesculus hippocastanum bark extract usage levels up to: | | | not for fragrance use.
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| Recommendation for aesculus hippocastanum bark extract flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | aesculus hippocastanum l. bark extract |
| Pubchem (sid): | 135344704 |
Other Information:
Potential Blenders and core components note
Potential Uses:
| | astringents |
| | skin conditioning |
| FL | tonic |
Occurrence (nature, food, other): note
Synonyms:
| horse | chestnut aesculus glabra bark extract | | horse | chestnut bark extract | | | extract of the bark of the horse chestnut, aesculus hippocastanum l., hippocastanaceae | | | hippocastanum vulgare bark extract |
Articles:
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