| Name: | piper methysticum extract |
| CAS Number: | 84696-40-2 |
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| ECHA EC Number: | 283-648-9 |
| FDA UNII: | Search |
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for piper methysticum extract usage levels up to: | | | not for fragrance use.
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| Recommendation for piper methysticum extract flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | piper methysticum extract |
| Pubchem (sid): | 135283770 |
Other Information:
| Export Tariff Code: | 1302.19.0000 |
| Wikipedia: | View |
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | extract of the leaves, roots and stems of the kawa-kawa, piper methysticum, piperaceae | | | kava-kava extract | | | kawa extract |
Articles:
| PubMed:Fatal kavalactone intoxication by suicidal intravenous injection. |
| PubMed:Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. |
| PubMed:Measuring the chemical and cytotoxic variability of commercially available kava (Piper methysticum G. Forster). |
| PubMed:Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. |
| PubMed:Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. |
| PubMed:Does a medicinal dose of kava impair driving? A randomized, placebo-controlled, double-blind study. |
| PubMed:Toxicology and carcinogenesis studies of kava kava extract (CAS No. 9000-38-8) in F344/N rats and B6C3F1 mice (Gavage Studies). |
| PubMed:[Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies]. |
| PubMed:Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate? |
| PubMed:Re-introduction of kava (Piper methysticum) to the EU: is there a way forward? |
| PubMed:Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. |
| PubMed:Kava hepatotoxicity: pathogenetic aspects and prospective considerations. |
| PubMed:Cyclodextrins as carriers for kavalactones in aqueous media: spectroscopic characterization of (S)-7,8-dihydrokavain and beta-cyclodextrin inclusion complex. |
| PubMed:Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. |
| PubMed:The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. |
| PubMed:Kava Anxiety Depression Spectrum Study (KADSS): a mixed methods RCT using an aqueous extract of Piper methysticum. |
| PubMed:Discriminative-stimulus and time-course effects of kava-kava (Piper methysticum) in rats. |
| PubMed:Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots. |
| PubMed:Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. |
| PubMed:Identification of C-glycoside flavonoids as potential mutagenic compounds in kava. |
| PubMed:Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. |
| PubMed:Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats. |
| PubMed:Melanogenesis stimulation in murine B16 melanoma cells by Kava (Piper methysticum) rhizome extract and kavalactones. |
| PubMed:Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). |
| PubMed:HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst. |
| PubMed:Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. |
| PubMed:Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard. |
| PubMed:Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.). |
| PubMed:Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. |
| PubMed:Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava). |
| PubMed:Kava does not display metabolic toxicity in a homogeneous cellular assay. |
| PubMed:Saccade and cognitive impairment associated with kava intoxication. |
| PubMed:Quantitative elimination of Flavokavines A and B from Kava Kava (Piper methysticum G. Forst) by isoelectric focused adsorptive bubble separation. |
| PubMed:Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. |
| PubMed:Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum). |
| PubMed:Identification of novel electrophilic metabolites of piper methysticum Forst (Kava). |
| PubMed:Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. |
| PubMed:Kava-Kava administration reduces anxiety in perimenopausal women. |
| PubMed:Saccade and cognitive function in chronic kava users. |
| PubMed:Kava extract for treating anxiety. |
| PubMed:Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). |
| PubMed:Anxiolytic-like effects of kava-kava in the elevated plus maze test--a comparison with diazepam. |
| PubMed:Densitometric analysis of kawain in kava-kava root extracts. |
| PubMed:Kava extract for treating anxiety. |
| PubMed:A systematic review of the safety of kava extract in the treatment of anxiety. |
| PubMed:Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots. |
| PubMed:Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme. |
| PubMed:Synergy and other interactions in phytomedicines. |
| PubMed:Kava extract for treating anxiety. |
| PubMed:Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review. |
| PubMed:Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm. |
| PubMed:Efficacy of kava extract for treating anxiety: systematic review and meta-analysis. |
| PubMed:Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). |
| PubMed:[Kava-kava preparations--alternative anxiolytics]. |
| PubMed:Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract. |
| PubMed:Efficacy of a special Kava extract (Piper methysticum) in patients with states of anxiety, tension and excitedness of non-mental origin - A double-blind placebo-controlled study of four weeks treatment. |
| PubMed:Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain. |
| PubMed:Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task. |
| PubMed:Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. |
| PubMed:Effect of aqueous and lipid-soluble extracts of kava on the conditioned avoidance response in rats. |
| PubMed:Comparison of the central nervous system activity of the aqueous and lipid extract of kava (Piper methysticum). |
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