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Category:fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | alcohol |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | fragrance agents |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| contains the following IFRA (Annex) restricted components: (non-analysis max. level reference only) |
| geraniol | Max. Found: <0.40 % and Reason: Sensitization |
| Recommendation for croton cajucara benth. leaf oil brazil usage levels up to: | | | 5.0000 % in the fragrance concentrate.
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| Recommendation for croton cajucara benth. leaf oil brazil flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | croton cajucara benth. leaf oil brazil |
Articles:
| PubMed:Effects of 7-Hydroxycalamenene Isolated from Croton cajucara Essential Oil on Growth, Lipid Content and Ultrastructural Aspects of Rhizopus oryzae. |
| PubMed:In vitro cytocidal effects of the essential oil from Croton cajucara (red sacaca) and its major constituent 7- hydroxycalamenene against Leishmania chagasi. |
| PubMed:Antioxidant and antimicrobial activities of 7-hydroxy-calamenene-rich essential oils from Croton cajucara Benth. |
| PubMed:Treatment with aqueous extract from Croton cajucara Benth reduces hepatic oxidative stress in streptozotocin-diabetic rats. |
| PubMed:Molecular phylogenetics and character evolution of the "sacaca" clade: novel relationships of Croton section Cleodora (Euphorbiaceae). |
| PubMed:Involvement of glutathione, sulfhydryl compounds, nitric oxide, vasoactive intestinal peptide, and heat-shock protein-70 in the gastroprotective mechanism of Croton cajucara Benth. (Euphorbiaceae) essential oil. |
| PubMed:Hepatics alterations and genotoxic effects of Croton cajucara Benth (SACACA) in diabetic rats. |
| PubMed:Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi. |
| PubMed:Vitamin E ameliorates high dose trans-dehydrocrotonin-associated hepatic damage in mice. |
| PubMed:The antiulcer effect of Croton cajucara Benth in normoproteic and malnourished rats. |
| PubMed:Histologic evaluation of rats' liver after Croton cajucara Benth (sacaca) administration. |
| PubMed:Protective effect of DCTN (trans-dehydrocrotonin) against induction of micronuclei and apoptosis by different mutagenic agents in vitro. |
| PubMed:The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats. |
| PubMed:Croton cajucara Benth. leaf extract scavenges the stable free radical DPPH and protects against oxidative stress induced by paraquat. |
| PubMed:Plant active components - a resource for antiparasitic agents? |
| PubMed:Cardiovascular effects of trans-dehydrocrotonin, a diterpene from Croton cajucara in rats. |
| PubMed:Antimicrobial activity of Croton cajucara Benth linalool-rich essential oil on artificial biofilms and planktonic microorganisms. |
| PubMed:Would Sacaca, Croton cajucara Benth (Euphorbiaceae) be an hepatotoxic plant like Germander, Teucrium chamaedrys L. (Labiatae)? |
| PubMed:Antiulcer activity and subacute toxicity of trans-dehydrocrotonin from Croton cajucara. |
| PubMed:Chronic treatment with bark infusion from Croton cajucara lowers plasma triglyceride levels in genetic hyperlipidemic mice. |
| PubMed:Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosis with lipid peroxidation and activation of caspases-2, -6 and -9 in human leukemic cells HL60. |
| PubMed:Antiulcerogenic effect and cytotoxic activity of semi-synthetic crotonin obtained from Croton cajucara Benth. |
| PubMed:Comparison of the gastroprotective effect of a diterpene lactone isolated from Croton cajucara with its synthetic derivatives. |
| PubMed:Influence of protein phosphatase inhibitors on HL60 cells death induction by dehydrocrotonin. |
| PubMed:Comparative cytotoxicity of dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells. |
| PubMed:Antileishmanial activity of a linalool-rich essential oil from Croton cajucara. |
| PubMed:Sensitivity to beta-adrenoceptor agonists of adipocytes from rats treated with an aqueous extract of Croton cajucara Benth. |
| PubMed:Cytotoxic effect of the diterpene lactone dehydrocrotonin from Croton cajucara on human promyelocytic leukemia cells. |
| PubMed:Effect of essential oil obtained from Croton cajucara Benth. on gastric ulcer healing and protective factors of the gastric mucosa. |
| PubMed:Derivatives of dehydrocrotonin, a diterpene lactone isolated from Croton cajucara: cytotoxicity in rat cultured hepatocytes and in V79 cells. |
| PubMed:Natural trans-crotonin: the antiulcerogenic effect of another diterpene isolated from the bark of Croton cajucara Benth. |
| PubMed:Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice. |
| PubMed:Blood glucose- and triglyceride-lowering effect of trans-dehydrocrotonin, a diterpene from Croton cajucara Benth., in rats. |
| PubMed:Antigenotoxicity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara. |
| PubMed:Effect of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara on experimental hypertriglyceridaemia and hypercholesterolaemia induced by Triton WR 1339 (tyloxapol) in mice. |
| PubMed:The lipid-lowering effect of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara Benth. in mice fed on high-fat diet. |
| PubMed:Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice. |
| PubMed:Evaluation of the gastroprotective activity of cordatin, a diterpene isolated from Aparisthmium cordatum (Euphorbiaceae). |
| PubMed:Ethnopharmacology, phytochemistry and pharmacology: a successful combination in the study of Croton cajucara. |
| PubMed:Gastroprotective effect of essential oil from Croton cajucara Benth. (Euphorbiaceae). |
| PubMed:Anti-inflammatory and antinociceptive effects in rodents of the essential oil of Croton cajucara Benth. |
| PubMed:Anti-tumour activity of two 19-nor-clerodane diterpenes, trans-dehydrocrotonin and trans-crotonin, from Croton cajucara. |
| PubMed:Antioestrogenic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara Benth. in rats. |
| PubMed:Investigation of genotoxic activity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara. |
| PubMed:Cytotoxicity of trans-dehydrocrotonin from Croton cajucara on V79 cells and rat hepatocytes. |
| PubMed:Antiulcerogenic mechanisms of dehydrocrotonin, a diterpene lactone obtained from Croton cajucara. |
| PubMed:Effects of an essential oil from the bark of Croton cajucara Benth. on experimental gastric ulcer models in rats and mice. |
| PubMed:Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara. |
| PubMed:Hypoglycemic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara. |
| PubMed:Investigation of anti-inflammatory and antinociceptive activities of trans-dehydrocrotonin, a 19-nor-clerodane diterpene from Croton cajucara. Part 1. |
| PubMed:Cajucarinolide and isocajucarinolide: anti-inflammatory diterpenes from Croton cajucara. |
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