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croton oil
croton tiglium oil

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Name:croton tiglium oil
CAS Number: 8001-28-3
FDA UNII: WK97EQG57S
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Food Chemicals Codex Listed: No
Soluble in:
 alcohol
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
India Essential Oils
Croton Oil
Flavor: acrid, disagreeable taste and a slight odor
Penta International
CROTON OIL
BOC Sciences
For experimental / research use only.
CROTON OIL 95%
Noble Molecular Research
For experimental / research use only.
Croton Oil
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-frog LD50 60 mg/kg
Zeitschrift fuer Krebsforschung. Vol. 65, Pg. 325, 1963.

parenteral-frog LD50 60 mg/kg
Zeitschrift fuer Krebsforschung. Vol. 65, Pg. 325, 1963.

intraperitoneal-mouse LDLo 1 mg/kg
Toxicology and Applied Pharmacology. Vol. 23, Pg. 288, 1972.

Dermal Toxicity:
subcutaneous-mouse LD70 3740 ug/kg
Toho Igakkai Zasshi. Journal of Medical Society of Toho University. Vol. 7, Pg. 1276, 1961.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for croton oil usage levels up to:
 not for fragrance use.
 
Recommendation for croton oil flavor usage levels up to:
 not for flavor use.
 
Safety References:
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):8001-28-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
croton tiglium oil
Chemidplus:0008001283
EPA/NOAA CAMEO:hazardous materials
 
References:
 croton tiglium oil
Pubchem (sid):135300953
 
Other Information:
Wikipedia:View
FAO:BASIC PRINCIPLES OF STEAM DISTILLATION
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 croton tiglium
Search Trop Picture
 
Synonyms:
 croton tiglium oil
 

Articles:

PubMed:Anticonvulsant effect of hydroalcoholic seed extract of croton tiglium in rats and mice.
PubMed:Cytotoxic phorbol esters of Croton tiglium.
PubMed:[GC-MS analysis of chemical components in seeds oil from Croton tiglium].
PubMed:[New processing procedure for Croton tiglium with study on comparison of Croton tiglium and processed product].
PubMed:Antinociceptive and Smooth Muscle Relaxant Activity of Croton tiglium L Seed: An In-vitro and In-vivo Study.
PubMed:Activation of M3 muscarinic receptor and Ca²⁺ influx by crude fraction from Crotonis Fructus in isolated rabbit jejunum.
PubMed:Anti-tumor activity of Aloe vera against DMBA/croton oil-induced skin papillomagenesis in Swiss albino mice.
PubMed:Toxic effects of crotocaudin extracted from the medicinal plant Croton tiglium.
PubMed:M3 muscarinic receptor- and Ca2+ influx-mediated muscle contractions induced by croton oil in isolated rabbit jejunum.
PubMed:Activity-guided isolation of a novel protein from Croton tiglium with antifungal and antibacterial activities.
PubMed:Characteristics, efficacy and safety testing of standardized extract of Croton tiglium seed from Indonesia as laxative material.
PubMed:Effects of essential oil from Croton tiglium L. on intestinal transit in mice.
PubMed:A novel analgesic pyrazine derivative from the leaves of Croton tiglium L.
PubMed:A DNA microarray for the authentication of toxic traditional Chinese medicinal plants.
PubMed:[Inhibitory effects of some traditional medicines on proliferation of HIV-1 and its protease].
PubMed:Effect of ethanol extracts of three Chinese medicinal plants with laxative properties on ion transport of the rat intestinal epithelia.
PubMed:Protein kinase C translocation by modified phorbol esters with functionalized lipophilic regions.
PubMed:Biotransformation of phorbol by human intestinal bacteria.
PubMed:Anti-HIV-1 phorbol esters from the seeds of Croton tiglium.
PubMed:Ethnomedicinally selected plants as sources of potential analgesic compounds: indication of in vitro biological activity in receptor binding assays.
PubMed:12-O-acetylphorbol-13-decanoate potently inhibits cytopathic effects of human immunodeficiency virus type 1 (HIV-1), without activation of protein kinase C.
PubMed:Gastro intestinal effects of croton tiglium in experimental animals.
PubMed:Sensitivity of ribosomes from Agrobacterium tumefaciens to the ribosome-inactivating protein crotin 2 depending on the translocational state.
PubMed:Isolation of isoguanosine from Croton tiglium and its antitumor activity.
PubMed:Screening of Epstein-Barr virus early antigen expression inducers from Chinese medicinal herbs and plants.
PubMed:Preliminary crystallographic studies of crotin II.
PubMed:Effects of ribosome-inactivating proteins on Escherichia coli and Agrobacterium tumefaciens translation systems.
PubMed:Preparation, optimization and characterization of a polyphenylalanine synthetizing system from Agrobacterium tumefaciens.
PubMed:Enterolobin, a hemolytic protein from Enterolobium contortisiliquum seeds (Leguminosae--Mimosoideae). Purification and characterization.
PubMed:A Method for Quantitative Determination of Polyfunctional Diterpene Esters of the Tigliane Type in Croton tiglium.
PubMed:[Historical studies on the processing of the fruits of Croton tiglium L.)].
PubMed:Purification and properties of a lectin from the seeds of Croton tiglium with hemolytic activity toward rabbit red cells.
PubMed:Combined effect of the extracts from Croton tiglium, Euphorbia lathyris or Euphorbia tirucalli and n-butyrate on Epstein-Barr virus expression in human lymphoblastoid P3HR-1 and Raji cells.
PubMed:alpha-Tocopherol inhibits 12-O-tetradecanoyl-phorbol-13-acetate-stimulated deacylation of cellular lipids, prostaglandin production, and changes in cell morphology of Madin-Darby canine kidney cells.
PubMed:Studies on the proteins from the seeds of Croton tiglium and of Jatropha curcas. Toxic properties and inhibition of protein synthesis in vitro.
PubMed:Antileukemic principles isolated from euphorbiaceae plants.
PubMed:Phorbolesters--the irritants and cocarcinogens of Croton Tiglium L.
PubMed:Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae.
PubMed:Tumor-promoting agents from Croton tiglium L. and their mode of action.
PubMed:Phenotypic expression of transformation: induction in cell culture by a phorbol ester.
PubMed:The tumor-enhancing principles of Croton tiglium L. II. A comparative study.
PubMed:The tumor-enhancing principles of Croton tiglium L.
PubMed:TUMOUR-ENHANCING ACTIVITY OF THE ACTIVE PRINCIPLES OF CROTON TIGLIUM L.
PubMed:THE TUMOR-ENHANCING AND IRRITANT PRINCIPLES FROM CROTON TIGLIUM L.
PubMed:[Croton tiglium powder as an auxiliary treatment in laryngeal obstruction due to diphtheria or laryngitis: preliminary report of 116 cases].
PubMed:Tumor promoting principles in seeds of Croton tiglium L.
PubMed:On a New Preparation of Croton Tiglium.
 
Notes:
tsca definition 2008: extractives and their physically modified derivatives. croton tiglium, euphorbiaceae.
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